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- Björk, Maria, 1978-
(författare)
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Problemet utan namn? : Neuroser, stress och kön i Sverige från 1950 till 1980
- 2011
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Focusing on Sweden between 1950 and 1980, this doctoral dissertation analyzes and problematizes the process in which a discourse about neurosis and nervous troubles gradually evolved into a discourse about stress. The thesis aims to show how the medical and general discussion about diffuse or vague symptoms transformed and rearticulated ideas and views on society and man, citizenship, gender roles, and medicine. It shows how the discourse on neuroses tended to locate sickness and deviance in the individual, whereas its subsequent transformation into a discourse on stress located the pathological in an external, societal sphere.A particularly prominent issue in the study concerns the role that gender, and in particular female gender, has played in these discourses, and how the place of the feminine can be understood in relation to stress and neuroses. The dissertation shows that female gender was not central to the discourse on neuroses and stress during the studied period. On the contrary, gender was subordinated to ideas about man and citizenship within the greater context of society and culture.The dissertation takes its starting point in the Swedish 1950’s, often characterized as the era of ”The Strong Society” or ”The People’s Home”. During this period, the neurosis discourse was fixed and remained unchanged. In practice, neurosis was a diagnosis that provided such symptoms that were otherwise difficult to measure and assess with a theory of origin. Neuroses were believed to principally affect a certain category of individuals, who, due to their constitution or disposition, were held to be particularly susceptible to neurotic sufferings.During the 1960s the belief in The Strong Society and its notion of ideal citizenship began to crumble. It was against this background that the Swedish medical profession started discussing ”stress”. Stress, in contrast, could afflict anyone and everyone, according to “the father of stress” Hans Selye and Swedish stress researchers. Stress was assumed to be a potential cause of ”nervous troubles” and disease, but was never considered to be a disease in itself. The concept of the individual as a citizen now gave way for the notion of the individual as a primarily biological organism. Within the stress discourse in the 1960s, the primacy of the universal normal (male) man was a recurring focal point.In the 1970s, the stress researchers distanced themselves from Selyes’ concept of stress by focusing on individual factors. In the discussion about stress during the 1970s, the ”constitutionally weak” individual of the 1950s and the biological organism of the 1960s blended into a hybrid construction of a unique, biological individual.
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- Björklund, Ann-Christin, et al.
(författare)
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Using ICF to Describe Problems With Functioning in Everyday Life for Children Who Completed Treatment for Brain Tumor : An Analysis Based on Professionals' Documentation
- 2021
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Ingår i: Frontiers in Rehabilitation Sciences. - : Frontiers Media S.A.. - 2673-6861. ; 2
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Tidskriftsartikel (refereegranskat)abstract
- Background: Children treated for brain tumors often experience persistent problems affecting their activity performance and participation in everyday life, especially in school. Linking these problems to the International Classification of Functioning, Disability and Health (ICF) classification system can be described as affecting body function, activity performance, and/or participation. Services involved in the everyday life of the child have different focus and goals when meeting the child in context, which advantage the use of ICF to overcome this impediment to follow-up and provide comprehensive support for children who have completed treatment for a brain tumor.Aim: The aim of the study was to use the ICF classification system to describe how professionals in healthcare, habilitation, and school document problems with everyday life functioning at body, activity, and participation levels for children who completed treatment for a brain tumor.Materials and Methods: A retrospective review of records from healthcare, habilitation, and school concerning nine children completed treatment for brain tumor was implemented. Identified problems in everyday life were linked to ICF codes. Descriptive statistics of ICF-linked code frequency supplemented by network visualization diagrams viewing the co-occurrence between codes within the body, activity participation, and environmental components were performed.Results: Most documented problems were found in healthcare records, whereas the documentation in habilitation and school was sparse. The frequently occurring codes, independent of record source, were linked to the body function component, and ICF-linked problems in habilitation and school were salient in the activity and participation component. To gain a holistic picture of relations between ICF codes and problems, network visualization diagrams were used to illustrate clusters of problems.Conclusion: Code prevalence likely reflects where healthcare professionals and educators focus their attention when meeting the needs of children treated for a brain tumor in context. To maximize the comprehensive view of functioning and participation of children in everyday life, the full range of difficulties regarding body impairments, activity limitations, and participation restrictions must be identified and linked to each other in patterns of co-occurrence, which the ICF facilitate. However, ICF provides no guidance on how to identify networks of problems within the body, activity, and participation. Identifying such networks is important for building comprehensive interventions for children.
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- Bonander, Carl, et al.
(författare)
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A regression discontinuity analysis of the social distancing recommendations for older adults in Sweden during COVID-19.
- 2022
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Ingår i: European Journal of Public Health. - : Oxford University Press. - 1101-1262 .- 1464-360X. ; 32:5, s. 799-806
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: This paper investigates the impact of a non-mandatory and age-specific social distancing recommendation on isolation behaviors and disease outcomes in Sweden during the first wave of the COVID-19 pandemic (March to July, 2020). The policy stated that people aged 70 years or older should avoid crowded places and contact with people outside the household.METHODS: We used a regression discontinuity design-in combination with self-reported isolation data from COVID Symptom Study Sweden (n = 96,053; age range: 39-79 years) and national register data (age range: 39-100+ years) on severe COVID-19 disease (hospitalization or death, n = 21,804) and confirmed cases (n = 48,984)-to estimate the effects of the policy.RESULTS: Our primary analyses showed a sharp drop in the weekly number of visits to crowded places (-13%) and severe COVID-19 cases (-16%) at the 70-year-threshold. These results imply that the age-specific recommendations prevented approximately 1,800 to 2,700 severe COVID-19 cases, depending on model specification.CONCLUSION: It seems that the non-mandatory, age-specific recommendations helped control COVID-19 disease during the first wave of the pandemic in Sweden, as opposed to not implementing a social distancing policy aimed at older adults. Our study provides empirical data on how populations may react to non-mandatory, age-specific social distancing policies in the face of a novel virus.SUPPLEMENTARY MATERIAL: Online appendix with figures, tables, extra methods and results.
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- Clausen, Fredrik, et al.
(författare)
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Neutralization of interleukin-1β modifies the inflammatory response and improves histological and cognitive outcome following traumatic brain injury in mice
- 2009
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Ingår i: European Journal of Neuroscience. - : Federation of European Neuroscience Societies and Blackwell Publishing Ltd. - 0953-816X .- 1460-9568. ; 30:3, s. 385-396
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Tidskriftsartikel (refereegranskat)abstract
- Interleukin-1beta (IL-1beta) may play a central role in the inflammatory response following traumatic brain injury (TBI). We subjected 91 mice to controlled cortical impact (CCI) brain injury or sham injury. Beginning 5 min post-injury, the IL-1beta neutralizing antibody IgG2a/k (1.5 microg/mL) or control antibody was infused at a rate of 0.25 microL/h into the contralateral ventricle for up to 14 days using osmotic minipumps. Neutrophil and T-cell infiltration and microglial activation was evaluated at days 1-7 post-injury. Cognition was assessed using Morris water maze, and motor function using rotarod and cylinder tests. Lesion volume and hemispheric tissue loss were evaluated at 18 days post-injury. Using this treatment strategy, cortical and hippocampal tissue levels of IgG2a/k reached 50 ng/mL, sufficient to effectively inhibit IL-1betain vitro. IL-1beta neutralization attenuated the CCI-induced cortical and hippocampal microglial activation (P < 0.05 at post-injury days 3 and 7), and cortical infiltration of neutrophils (P < 0.05 at post-injury day 7). There was only a minimal cortical infiltration of activated T-cells, attenuated by IL-1beta neutralization (P < 0.05 at post-injury day 7). CCI induced a significant deficit in neurological motor and cognitive function, and caused a loss of hemispheric tissue (P < 0.05). In brain-injured animals, IL-1beta neutralizing treatment resulted in reduced lesion volume, hemispheric tissue loss and attenuated cognitive deficits (P < 0.05) without influencing neurological motor function. Our results indicate that IL-1beta is a central component in the post-injury inflammatory response that, in view of the observed positive neuroprotective and cognitive effects, may be a suitable pharmacological target for the treatment of TBI.
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- Dahlin, Maria, et al.
(författare)
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Transfer of dopamine in the olfactory pathway following nasal administration in mice
- 2000
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Ingår i: Pharmaceutical research. - 0724-8741 .- 1573-904X. ; 17:6, s. 737-742
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: The aim of the study was to investigate whether dopamine is transferred along the olfactory pathway to the brain following nasal administration to mice. METHODS: [3H]-Dopamine was administered nasally or intravenously to female mice. Brain tissue samples were excised and the radioactive content was measured. The precise localisation of dopamine radioactivity in the brain was studied using autoradiography. The presence of dopamine or its metabolites in the olfactory bulb and mucosa was ascertained using thin layer chromatography (TLC). RESULTS: After administration of [3H]-dopamine into the right nostril, the amount of dopamine in the right bulb increased with time until. after 4 h, it was 27 times higher than in the left bulb. Among the other brain tissue samples, significantly higher amount of radioactivity was detected in the lateral olfactory tract. Radioactivity in the right olfactory bulb was shown by autoradiography to be selectively located in the peripheral layers 1 to 4 h after administration. Selective uptake of radioactivity was not seen in other regions of the brain. TLC data indicated that approximately 75% and 10% of the radioactivity in the olfactory bulb and mucosa, respectively, coeluted with dopamine. CONCLUSIONS: The results indicate that unchanged dopamine is transferred into the olfactory bulb following nasal administration of [3H]-dopamine.
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- Elmendorf, Sarah C., et al.
(författare)
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Global assessment of experimental climate warming on tundra vegetation : heterogeneity over space and time
- 2012
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Ingår i: Ecology Letters. - : Wiley. - 1461-023X .- 1461-0248. ; 15:2, s. 164-175
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Forskningsöversikt (refereegranskat)abstract
- Understanding the sensitivity of tundra vegetation to climate warming is critical to forecasting future biodiversity and vegetation feedbacks to climate. In situ warming experiments accelerate climate change on a small scale to forecast responses of local plant communities. Limitations of this approach include the apparent site-specificity of results and uncertainty about the power of short-term studies to anticipate longer term change. We address these issues with a synthesis of 61 experimental warming studies, of up to 20 years duration, in tundra sites worldwide. The response of plant groups to warming often differed with ambient summer temperature, soil moisture and experimental duration. Shrubs increased with warming only where ambient temperature was high, whereas graminoids increased primarily in the coldest study sites. Linear increases in effect size over time were frequently observed. There was little indication of saturating or accelerating effects, as would be predicted if negative or positive vegetation feedbacks were common. These results indicate that tundra vegetation exhibits strong regional variation in response to warming, and that in vulnerable regions, cumulative effects of long-term warming on tundra vegetation and associated ecosystem consequences have the potential to be much greater than we have observed to date.
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