| 1. |
- Björklund, Anders, et al.
(författare)
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Preface
- 2010
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Ingår i: Recent Advances in Parkinson’S Disease Translational and Clinical Research. - 9780444537508 ; 184
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 2. |
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| 3. |
- Dunnett, Stephen B, et al.
(författare)
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Introduction (Part I)
- 2012
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Ingår i: Functional Neural Transplantation III : Primary and stem cell therapies for brain repair. Part 1 - Primary and stem cell therapies for brain repair. Part 1. - 0079-6123. - 9780444595751 ; 200, s. 3-5
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Bokkapitel (refereegranskat)
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| 4. |
- Dunnett, Stephen B, et al.
(författare)
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Introduction (Part II)
- 2012
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Ingår i: Functional Neural Transplantation III : Primary and Stem Cell Therapies for Brain Repair, Part II - Primary and Stem Cell Therapies for Brain Repair, Part II. - 0079-6123. - 9780444595447 ; 201, s. 3-5
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Bokkapitel (refereegranskat)
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| 5. |
- Thompson, Lachlan, et al.
(författare)
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Survival, differentiation, and connectivity of ventral mesencephalic dopamine neurons following transplantation
- 2012
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Ingår i: Functional Neural Transplantation III : Primary and Stem Cell Therapies for Brain Repair, Part I - Primary and Stem Cell Therapies for Brain Repair, Part I. - 0079-6123. - 9780444595751 ; 200, s. 61-95
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Bokkapitel (refereegranskat)abstract
- The reconstruction of midbrain dopamine (DA) circuitry through intracerebral transplantation of new DA neurons contained in embryonic ventral mesencephalon (VM) is a promising therapeutic approach for Parkinson's disease (PD). Although some of the early open-label trials have provided proof-of-principal that VM grafts can provide sustained improvement of motor function in some patients, subsequent trials showed that the functional response can be highly variable. This chapter reviews an extensive body of basic and clinical research on the survival, differentiation, and connectivity of DA neurons in VM grafts, and also looks at how these parameters are affected by certain host- and donor-specific variables. We also review how technical advances in the tools available to study the integration of grafted DA neurons, such as transgenic reporter mice, have made significant contributions to our understanding of the capacity of different DA neuronal subtypes for target-directed growth and innervation of appropriate host brain structures. Our established and on-going understanding of the capacity of grafted DA neurons to structurally and functionally integrate following transplantation forms an important basis for the refinement and optimization of VM grafting procedures, and also the development of new procedures based on the use of stem cells.
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| 6. |
- Björklund, Anders, 1950-, et al.
(författare)
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Arbetsmarknaden
- 2014. - 4
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Bok (övrigt vetenskapligt/konstnärligt)
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| 7. |
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| 8. |
- Björklund, Anders, et al.
(författare)
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Gene therapy for dopamine replacement in Parkinson's disease.
- 2009
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Ingår i: Science Translational Medicine. - : American Association for the Advancement of Science (AAAS). - 1946-6242 .- 1946-6234. ; 1:2, s. 2-2
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Tidskriftsartikel (refereegranskat)abstract
- The introduction of L-dopa (L-3,4-dihydroxyphenylalanine) therapy 40 years ago was a revolution in the treatment of patients with Parkinson s disease (PD). With time, however, the shortcomings of oral L-dopa medication became apparent, in particular the appearance of troublesome side effects, expressed as involuntary movements (dyskinesias) that developed over time in many patients. A gene therapy approach, aimed at restoring dopamine synthesis in the affected brain by viral vector delivery of genes that encode the dopamine-synthesizing enzymes, may offer a solution to this problem. Now, a team of French and UK researchers reports promising results in a nonhuman primate model of PD, paving the way for clinical trials of this enzyme-replacement approach.
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| 9. |
- Björklund, Anders, et al.
(författare)
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Gene therapy for Parkinson's disease shows promise.
- 2011
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Ingår i: Science Translational Medicine. - : American Association for the Advancement of Science (AAAS). - 1946-6242 .- 1946-6234. ; 3:79, s. 1-79
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Tidskriftsartikel (refereegranskat)abstract
- A gene therapy trial for Parkinson's disease met its primary endpoint, but challenges remain.
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| 10. |
- Böhlmark, Anders, 1973-
(författare)
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School Reform, Educational Achievement and Lifetime Income : Essays in Empirical Labor Economics
- 2007
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The Impact of School Choice on Pupil Achievement, Segregation and Costs: Swedish Evidence. This paper evaluates school choice at the compulsory school level. We estimate the impact of an increased enrolment in private schools on average achievement using within-municipality variation over time. We find positive effects, shown to be the sum of a (small) private school attendance effect and a competition effect. We also find effects on segregation and costs.Age at Immigration and School Performance: A Siblings Analysis Using Swedish Register Data. This paper analyzes the role of age at immigration for the school performance gap between native and immigrant pupils by exploiting within-family variation. The critical age is about nine, above which there is a strong negative impact on performance. The results are similar for boys and girls, but vary by region of origin. A comparison of sibling-difference and cross-sectional estimates reveals striking similarities. Integration of Childhood Immigrants in the Short and in the Long Run: Swedish Evidence. I study childhood immigrants at different stages in life in order to examine the role of age at immigration for educational and labor market outcomes. I find that childhood immigrants tend later to recover strongly in terms of educational achievement. Yet, the same individuals are on average found to be poorly integrated into the labor market. Life-Cycle Variations in the Association between Current and Lifetime Income: Replication and Extension for Sweden. We apply a generalized errors-in-variables model, recently developed by Steven Haider and Gary Solon, in order to produce estimates of the association between current and lifetime income. We find strong life-cycle patterns. This implies that the widespread use of current income as a proxy for lifetime income leads to inconsistent estimates even when the proxy is used as the dependent variable. We find country similarities, but gender and cohort differences.
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