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  • Mazzurana, Luca, et al. (författare)
  • Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing
  • 2021
  • Ingår i: Cell Research. - : Science Press. - 1001-0602 .- 1748-7838. ; 31:5, s. 554-568
  • Tidskriftsartikel (refereegranskat)abstract
    • The impact of the microenvironment on innate lymphoid cell (ILC)-mediated immunity in humans remains largely unknown. Here we used full-length Smart-seq2 single-cell RNA-sequencing to unravel tissue-specific transcriptional profiles and heterogeneity of CD127+ ILCs across four human tissues. Correlation analysis identified gene modules characterizing the migratory properties of tonsil and blood ILCs, and signatures of tissue-residency, activation and modified metabolism in colon and lung ILCs. Trajectory analysis revealed potential differentiation pathways from circulating and tissue-resident naïve ILCs to a spectrum of mature ILC subsets. In the lung we identified both CRTH2+ and CRTH2− ILC2 with lung-specific signatures, which could be recapitulated by alarmin-exposure of circulating ILC2. Finally, we describe unique TCR-V(D)J-rearrangement patterns of blood ILC1-like cells, revealing a subset of potentially immature ILCs with TCR-δ rearrangement. Our study provides a useful resource for in-depth understanding of ILC-mediated immunity in humans, with implications for disease.
  • Uhlén, Mathias, et al. (författare)
  • A human protein atlas for normal and cancer tissues based on antibody proteomics
  • 2005
  • Ingår i: Molecular & Cellular Proteomics. - 1535-9476 .- 1535-9484. ; 4:12, s. 1920-1932
  • Tidskriftsartikel (refereegranskat)abstract
    • Antibody-based proteomics provides a powerful approach for the functional study of the human proteome involving the systematic generation of protein-specific affinity reagents. We used this strategy to construct a comprehensive, antibody-based protein atlas for expression and localization profiles in 48 normal human tissues and 20 different cancers. Here we report a new publicly available database containing, in the first version, similar to 400,000 high resolution images corresponding to more than 700 antibodies toward human proteins. Each image has been annotated by a certified pathologist to provide a knowledge base for functional studies and to allow queries about protein profiles in normal and disease tissues. Our results suggest it should be possible to extend this analysis to the majority of all human proteins thus providing a valuable tool for medical and biological research.
  • Kronenberg, Jakub, et al. (författare)
  • The thorny path toward greening : unintended consequences, trade-offs, and constraints in green and blue infrastructure planning, implementation, and management
  • 2021
  • Ingår i: Ecology & society. - : RESILIENCE ALLIANCE. - 1708-3087 .- 1708-3087. ; 2
  • Tidskriftsartikel (refereegranskat)abstract
    • Urban green and blue space interventions may bring about unintended consequences, involving trade-offs between the different land uses, and indeed, between the needs of different urban inhabitants, land users, and owners. Such trade-offs include choices between green/blue and non-green/blue projects, between broader land sparing vs. land sharing patterns, between satisfying the needs of the different inhabitants, but also between different ways of arranging the green and blue spaces. We analyze investment and planning initiatives in six case-study cities related to green and blue infrastructure (GBI) through the lens of a predefined set of questions an analytical framework based on the assumption that the flows of benefits from GBI to urban inhabitants and other stakeholders are mediated by three filters: infrastructures, institutions, and perceptions. The paper builds on the authors' own knowledge and experience with the analyzed case-study cities and beyond, a literature overview, a review of the relevant city documents, and interviews with key informants. The case studies indicate examples of initiatives that were intended to make GBI benefits available and accessible to urban inhabitants, in recognition of GBI as spaces with diverse functionality. Some case studies provide examples of trade-offs in trying to plan and design a green space for multiple private and public interests in densely built-up areas. The unintended consequences most typically resulted from the underappreciation of the complexity of social-ecological systems and more specifically the complexity of the involved infrastructures, institutions, and perceptions. The most important challenges addressed in the paper include trade-offs between the different ways of satisfying the residents' different needs related to the benefits from ecosystem services, ensuring proper recognition of the inhabitants' needs and perceptions, ecogentrification, caveats related to the formalization of informal spaces, and the need to consider temporal dynamics and cross-scale approaches that compromise different goals at different geographical scales.
  • Lundkvist, Erik, et al. (författare)
  • Relating Competitive Golfers' Perceived Emotions and Performance.
  • 2021
  • Ingår i: Perceptual and Motor Skills. - Thousand Oaks : Sage Publications. - 0031-5125 .- 1558-688X. ; 128:4, s. 1549-4568
  • Tidskriftsartikel (refereegranskat)abstract
    • The present study examined relationships between golfers' self-perceived emotions (e.g., irritability, nervousness, tension), task-oriented coping, perceived control, and performance during a golf competition. We implemented a process-oriented golf analysis in which competitors rated these variables hole-by-hole in a competitive golf round. Within a two-level Bayesian multivariate autoregressive model, we showed that (a) within persons, emotions and task-oriented coping were reactions that stemmed from performance on the previous hole; and (b) between persons, player skill level predicted both better scores and the ability to limit the influence of negative affect on performance. These findings highlight the complex nature of the relationship between emotions and performance. Future studies might use a similarly ecologically valid research design to more precisely measure aspects of time and potentially moderating effects of player skill level and personality. An increased understanding of the dynamic relationship between emotions and performance can promote the development of effective psychological interventions for optimal performance outcomes.
  • Lundström, Mats, et al. (författare)
  • Assessing student theses : differences and similarities between examiners from different academic disciplines
  • 2016
  • Ingår i: Practitioner Research in Higher Education. - : University of Cumbria. - 1755-1382. ; 10:1, s. 217-226
  • Tidskriftsartikel (refereegranskat)abstract
    • The writing of student theses is an important activity at universities and is expected to demonstrate the students’ academic skills. In the teacher-education programme, examiners from different academic disciplines are involved in supervising and examining student theses. Moreover, different subject disciplines have different traditions concerning what is seen as knowledge and the way research is performed, which could result in different assessment practices and judgements. Earlier studies demonstrate a fragmented picture concerning the importance of the examiners’ academic discipline in judging theses. The purpose of this article is to investigate whether examiners from different academic subject disciplines emphasise similar or different criteria when assessing student theses. A total of 66 examiners from six universities with teacher education programmes in Sweden have answered an online Q-survey where they compared different criteria and rank-ordered them. The results demonstrate minor differences between individuals from different academic disciplines: Only two out of the 45 criteria had significant differences between academic discipline groups. Thus, the results indicate that teacher education is a boundary-crossing, multi-disciplinary field which primarily uses generic criteria.
  • Norman, Mikael, et al. (författare)
  • The Swedish Neonatal Quality Register - contents, completeness and validity
  • 2019
  • Ingår i: Acta Paediatrica. - : WILEY. - 0803-5253 .- 1651-2227. ; 108:8, s. 1411-1418
  • Tidskriftsartikel (refereegranskat)abstract
    • Aim: To describe the Swedish Neonatal Quality Register (SNQ) and to determine its completeness and agreement with other registers.Methods: SNQ collects data for infants admitted to neonatal units during the first four postnatal weeks. Completeness and registers' agreement were determined cross-linking SNQ data with Swedish population registers (the Inpatient, Medical Birth and Cause of Death Registers) for a study period of five years.Results: In total, 84 712 infants were hospitalised. A total of 52 806 infants occurred in both SNQ and the population registers; 28 692 were only found in the population registers, and 3214 infants were only found in SNQ. Between gestational weeks 24-34, completeness of SNQ was 98-99%. Below and above these gestational ages, completeness was lower. Infants missing in SNQ were term or near-term in 99% of the cases, and their diagnoses indicated conditions managed in maternity units, or re-admissions for acute infections, managed in paediatric units. For most diagnoses, the agreement between SNQ and population registers was high, but some (bronchopulmonary dysplasia and grade of hypoxic-ischaemic encephalopathy) were often missing in the population registers.Conclusion: SNQ completeness and agreement against other registers, especially for preterm infants, is excellent. SNQ is a valid tool for benchmarking, quality improvement and research.
  • Thörn, Ingrid, et al. (författare)
  • Minimal residual disease assessment in childhood acute lymphoblastic leukaemia: a Swedish multi-centre study comparing real-time polymerase chain reaction and multicolour flow cytometry.
  • 2011
  • Ingår i: British journal of haematology. - : Wiley-Blackwell. - 1365-2141 .- 0007-1048. ; 152:6, s. 743-753
  • Tidskriftsartikel (refereegranskat)abstract
    • Minimal residual disease (MRD) assessment is a powerful prognostic factor for determining the risk of relapse in childhood acute lymphoblastic leukaemia (ALL). In this Swedish multi-centre study of childhood ALL diagnosed between 2002 and 2006, the MRD levels were analysed in 726 follow-up samples in 228 children using real-time quantitative polymerase chain reaction (RQ-PCR) of rearranged immunoglobulin/T-cell receptor genes and multicolour flow cytometry (FCM). Using an MRD threshold of 0·1%, which was the sensitivity level reached in all analyses, the concordance between RQ-PCR and FCM MRD values at day 29 was 84%. In B-cell precursor ALL, an MRD level of ≥0·1% at day 29 predicted a higher risk of bone marrow relapse (BMR) with both methods, although FCM was a better discriminator. However, considering the higher median MRD values achieved with RQ-PCR, a higher MRD cut-off (≥0·2%) improved the predictive capacity of RQ-PCR. In T-ALL, RQ-PCR was notably superior to FCM in predicting risk of BMR. That notwithstanding, MRD levels of ≥0·1%, detected by either method at day 29, could not predict isolated extramedullary relapse. In conclusion, the concordance between RQ-PCR and FCM was high and hence both methods are valuable clinical tools for identifying childhood ALL cases with increased risk of BMR.
  • Wikner, Evelina, 1987, et al. (författare)
  • How the utilised SOC window in commercial Li-ion pouch cells influence battery ageing
  • 2021
  • Ingår i: JOURNAL OF POWER SOURCES ADVANCES. - : Elsevier BV. - 2666-2485. ; 8
  • Tidskriftsartikel (refereegranskat)abstract
    • In many lithium-ion battery (LIB) applications, e.g. hybrid vehicles and load-levelling storage systems, only part of the state-of-charge (SOC) range needs to be utilised. This offers the possibility to use an optimal SOC window to avoid LIB ageing. Here, a large test matrix is designed to study LIB ageing in a commercial 26 Ah pouch cell, in order to map the ageing behaviour at different SOC levels with respect to temperature and current. A quantification of the degradation modes, loss of lithium inventory (LLI), loss of active positive (LAM(PE)) and negative (LAM(NE)) electrode materials is made by analysing the change in the open circuit voltage (OCV). A key result is that lower SOC intervals significantly improved battery ageing. Even during harsh test conditions, such as high Crates and temperatures, the cells deliver more than three times the expected number of full cycle equivalents. High SOC combined with high C-rate increase ageing where the dominating ageing mechanisms are LLI, followed by LAM(PE).
  • Zindovic, Igor, et al. (författare)
  • Predictors and impact of massive bleeding in acute type A aortic dissection
  • 2017
  • Ingår i: Interactive Cardiovascular and Thoracic Surgery. - : European Association of Cardio-Thoracic Surgery. - 1569-9293 .- 1569-9285. ; 24:4, s. 498-505
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVES: Bleeding complications associated with acute type A aortic dissection (aTAAD) are a well-known clinical problem. Here, we evaluated predictors of massive bleeding related to aTAAD and associated surgery and assessed the impact of massive bleeding on complications and survival. METHODS: This retrospective study of 256 patients used Blood Conservation Using Antifibrinolytics in a Randomized Trial (BART) criteria to define massive bleeding, which was met by 66 individuals (Group I) who were compared to the remaining patients (Group II). Multivariable logistic regression was used to identify independent predictors of massive bleeding and in-hospital mortality, Kaplan-Meier estimates for analysis of late survival, and Cox regression analysis to evaluate independent predictors of late mortality. RESULTS: Independent predictors of massive bleeding included symptom duration (odds ratio [OR], 0.974 per hour increment; 95% confidence interval [CI], 0.950-0.999; P = 0.041) and DeBakey type 1 dissection (OR, 2.652; 95% CI, 1.004-7.008; P = 0.049). In-hospital mortality was higher in Group I (30.3% vs 8.0%, P <0.001). Kaplan-Meier estimates of survival indicated poorer survival for Group I at 1, 3 and 5 years (68.8 ± 5.9% vs 92.8 ± 1.9%; 65.2 ± 6.2% vs 85.3 ± 2.7%; 53.9 ± 6.9% vs 82.1 ± 3.3 %, respectively; log rank P < 0.001). Re-exploration for bleeding was an independent predictor of in-hospital (OR, 3.109; 95% CI, 1.044-9.256; P = 0.042) and late mortalities (hazard ratio, 3.039; 95% CI, 1.605-5.757; P = 0.001). CONCLUSIONS: Massive bleeding in patients with aTAAD is prompted by shorter symptom duration and longer extent of dissection and has deleterious effects on outcomes of postoperative complications as well as in-hospital and late mortalities.
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