| 1. |
- Kronenberg, Jakub, et al.
(author)
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The thorny path toward greening : unintended consequences, trade-offs, and constraints in green and blue infrastructure planning, implementation, and management
- 2021
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In: Ecology & Society. - : Resilience Alliance, Inc.. - 1708-3087. ; 26:2
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Journal article (peer-reviewed)abstract
- Urban green and blue space interventions may bring about unintended consequences, involving trade-offs between the different land uses, and indeed, between the needs of different urban inhabitants, land users, and owners. Such trade-offs include choices between green/blue and non-green/blue projects, between broader land sparing vs. land sharing patterns, between satisfying the needs of the different inhabitants, but also between different ways of arranging the green and blue spaces. We analyze investment and planning initiatives in six case-study cities related to green and blue infrastructure (GBI) through the lens of a predefined set of questions an analytical framework based on the assumption that the flows of benefits from GBI to urban inhabitants and other stakeholders are mediated by three filters: infrastructures, institutions, and perceptions. The paper builds on the authors' own knowledge and experience with the analyzed case-study cities and beyond, a literature overview, a review of the relevant city documents, and interviews with key informants. The case studies indicate examples of initiatives that were intended to make GBI benefits available and accessible to urban inhabitants, in recognition of GBI as spaces with diverse functionality. Some case studies provide examples of trade-offs in trying to plan and design a green space for multiple private and public interests in densely built-up areas. The unintended consequences most typically resulted from the underappreciation of the complexity of social-ecological systems and more specifically the complexity of the involved infrastructures, institutions, and perceptions. The most important challenges addressed in the paper include trade-offs between the different ways of satisfying the residents' different needs related to the benefits from ecosystem services, ensuring proper recognition of the inhabitants' needs and perceptions, ecogentrification, caveats related to the formalization of informal spaces, and the need to consider temporal dynamics and cross-scale approaches that compromise different goals at different geographical scales.
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| 2. |
- Lundström, Mats, et al.
(author)
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Assessing student theses : differences and similarities between examiners from different academic disciplines
- 2016
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In: Practitioner Research in Higher Education. - : University of Cumbria. - 1755-1382. ; 10:1, s. 217-226
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Journal article (peer-reviewed)abstract
- The writing of student theses is an important activity at universities and is expected to demonstrate the students’ academic skills. In the teacher-education programme, examiners from different academic disciplines are involved in supervising and examining student theses. Moreover, different subject disciplines have different traditions concerning what is seen as knowledge and the way research is performed, which could result in different assessment practices and judgements. Earlier studies demonstrate a fragmented picture concerning the importance of the examiners’ academic discipline in judging theses. The purpose of this article is to investigate whether examiners from different academic subject disciplines emphasise similar or different criteria when assessing student theses. A total of 66 examiners from six universities with teacher education programmes in Sweden have answered an online Q-survey where they compared different criteria and rank-ordered them. The results demonstrate minor differences between individuals from different academic disciplines: Only two out of the 45 criteria had significant differences between academic discipline groups. Thus, the results indicate that teacher education is a boundary-crossing, multi-disciplinary field which primarily uses generic criteria.
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| 3. |
- Uhlén, Mathias, et al.
(author)
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A human protein atlas for normal and cancer tissues based on antibody proteomics
- 2005
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In: Molecular & Cellular Proteomics. - 1535-9476 .- 1535-9484. ; 4:12, s. 1920-1932
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Journal article (peer-reviewed)abstract
- Antibody-based proteomics provides a powerful approach for the functional study of the human proteome involving the systematic generation of protein-specific affinity reagents. We used this strategy to construct a comprehensive, antibody-based protein atlas for expression and localization profiles in 48 normal human tissues and 20 different cancers. Here we report a new publicly available database containing, in the first version, similar to 400,000 high resolution images corresponding to more than 700 antibodies toward human proteins. Each image has been annotated by a certified pathologist to provide a knowledge base for functional studies and to allow queries about protein profiles in normal and disease tissues. Our results suggest it should be possible to extend this analysis to the majority of all human proteins thus providing a valuable tool for medical and biological research.
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| 4. |
- Zindovic, Igor, et al.
(author)
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Predictors and impact of massive bleeding in acute type A aortic dissection.
- 2017
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In: Interactive Cardiovascular and Thoracic Surgery. - : Oxford University Press (OUP). - 1569-9293 .- 1569-9285. ; 24:4, s. 498-505
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Journal article (peer-reviewed)abstract
- Objectives: Bleeding complications associated with acute type A aortic dissection (aTAAD) are a well-known clinical problem. Here, we evaluated predictors of massive bleeding related to aTAAD and associated surgery and assessed the impact of massive bleeding on complications and survival.Methods: This retrospective study of 256 patients used Blood Conservation Using Antifibrinolytics in a Randomized Trial (BART) criteria to define massive bleeding, which was met by 66 individuals (Group I) who were compared to the remaining patients (Group II). Multivariable logistic regression was used to identify independent predictors of massive bleeding and in-hospital mortality, Kaplan-Meier estimates for analysis of late survival, and Cox regression analysis to evaluate independent predictors of late mortality.Results: Independent predictors of massive bleeding included symptom duration (odds ratio [OR], 0.974 per hour increment; 95% confidence interval [CI], 0.950-0.999; P = 0.041) and DeBakey type 1 dissection (OR, 2.652; 95% CI, 1.004-7.008; P = 0.049). In-hospital mortality was higher in Group I (30.3% vs 8.0%, P <0.001). Kaplan-Meier estimates of survival indicated poorer survival for Group I at 1, 3 and 5 years (68.8 ± 5.9% vs 92.8 ± 1.9%; 65.2 ± 6.2% vs 85.3 ± 2.7%; 53.9 ± 6.9% vs 82.1 ± 3.3 %, respectively; log rank P < 0.001). Re-exploration for bleeding was an independent predictor of in-hospital (OR, 3.109; 95% CI, 1.044-9.256; P = 0.042) and late mortalities (hazard ratio, 3.039; 95% CI, 1.605-5.757; P = 0.001).Conclusions: Massive bleeding in patients with aTAAD is prompted by shorter symptom duration and longer extent of dissection and has deleterious effects on outcomes of postoperative complications as well as in-hospital and late mortalities.
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| 5. |
- Adli, Erik, et al.
(author)
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Progress Of The Ess Proton Beam Imaging Systems
- 2022
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In: LINAC2022. - : ACoW Publishing. ; , s. 395-398
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Conference paper (peer-reviewed)abstract
- The ESS Target Proton Beam Imaging Systems has the objective to image the 5 MW ESS proton beam as it entersthe spallation target. The imaging systems has to operate in a harsh radiation environment, leading to a number of challenges : development of radiation hard photon sources, long and aperture-restricted optical paths and fast electronics required to provide rapid information in case of beam anomalies. This paper outlines how main challenges of the imaging systems have been addressed, and the status of deployment as ESS gets closer to beam.
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| 6. |
- Andersson, Erik, 1984-, et al.
(author)
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Anaerobic Capacity in Running : The Effect of Computational Method
- 2021
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In: Frontiers in Physiology. - : Frontiers Media S.A.. - 1664-042X. ; 12:August, s. 1-13
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Journal article (peer-reviewed)abstract
- Introduction: To date, no study has compared anaerobic capacity (AnC) estimates computed with the maximal accumulated oxygen deficit (MAOD) method and the gross energy cost (GEC) method applied to treadmill running exercise.Purpose: Four different models for estimating anaerobic energy supply during treadmill running exercise were compared.Methods: Fifteen endurance-trained recreational athletes performed, after a 10-min warm-up, five 4-min stages at ∼55–80% of peak oxygen uptake, and a 4-min time trial (TT). Two linear speed-metabolic rate (MR) regression models were used to estimate the instantaneous required MR during the TT (MRTT_req), either including (5+YLIN) or excluding (5-YLIN) a measured Y-intercept. Also, the average GEC (GECAVG) based on all five submaximal stages, or the GEC based on the last submaximal stage (GECLAST), were used as models to estimate the instantaneous MRTT_req. The AnC was computed as the difference between the MRTT_req and the aerobic MR integrated over time.Results: The GEC remained constant at ∼4.39 ± 0.29 J⋅kg–1⋅m–1 across the five submaximal stages and the TT was performed at a speed of 4.7 ± 0.4 m⋅s–1. Compared with the 5-YLIN, GECAVG, and GECLAST models, the 5+YLIN model generated a MRTT_req that was ∼3.9% lower, with corresponding anaerobic capacities from the four models of 0.72 ± 0.20, 0.74 ± 0.16, 0.74 ± 0.15, and 0.54 ± 0.14 kJ⋅kg–1, respectively (F1.07,42 = 13.9, P = 0.002). The GEC values associated with the TT were 4.22 ± 0.27 and 4.37 ± 0.30 J⋅kg–1⋅m–1 for 5+YLIN and 5-YLIN, respectively (calculated from the regression equation), and 4.39 ± 0.28 and 4.38 ± 0.27 J⋅kg–1⋅m–1 for GECAVG and GECLAST, respectively (F1.08,42 = 14.6, P < 0.001). The absolute typical errors in AnC ranged between 0.03 and 0.16 kJ⋅kg–1 for the six pair-wise comparisons and the overall standard error of measurement (SEM) was 0.16 kJ⋅kg–1.Conclusion: These findings demonstrate a generally high disagreement in estimated anaerobic capacities between models and show that the inclusion of a measured Y-intercept in the linear regression (i.e., 5+YLIN) is likely to underestimate the MRTT_req and the GEC associated with the TT, and hence the AnC during maximal 4-min treadmill running.
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| 7. |
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| 8. |
- Andersson, Erik, et al.
(author)
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Energy contributions and pacing strategies of elite XC skiers during sprint skiing
- 2016
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Conference paper (peer-reviewed)abstract
- INTRODUCTION: At present, knowledge regarding energy contributions and pacing strategies during successive sprint time-trials (STTs) in cross-country (XC) skiing is limited and, therefore, the current study was designed to examine these parameters. The results shown have recently been published elsewhere (Andersson et al., 2016).METHODS: Ten well-trained male XC skiers performed four self-paced 1300-m STTs on a treadmill, separated by 45 min of recovery. The simulated STT course was divided into three flat (1°) sections (S1, S3 and S5) involving the double poling (DP) sub-technique interspersed with two uphill (7°) sections (S2 and S4) involving the diagonal stride (DS) sub-technique. Treadmill velocity and VO2 were monitored continuously and technique-specific gross efficiency (based on submaximal pre-tests) was used to estimate anaerobic energy production.RESULTS & DISCUSSION: The average STT performance time was 229 ± 9 s and the aerobic energy contribution was 82 ± 5%. A positive pacing strategy was used during all STTs, with 3-9% more time spent on the second half of the course (P < 0.05). In addition, the pacing strategy was regulated to the terrain, with substantially higher (~30%) metabolic rates, due to primarily higher anaerobic energy production, for uphill compared with flat skiing (P < 0.05). The individually fastest STT was more aggressively paced compared to the slowest STT (P < 0.05), which resulted in a higher O2 deficit rate (13 ± 4 versus 11 ± 4 mL/kg/min, P < 0.05), while the VO2 was similar (both 52 ± 3 mL/kg/min). These findings emphasise the importance of a fast start. The within-athlete coefficient of variation (CV) in performance time, VO2 and O2 deficit were 1.3 ± 0.4%, 1.4 ± 0.9% and 11.2 ± 4.9%, respectively, with the CV in O2 deficit explaining 69% of the CV in performance. The pacing strategies were highly consistent, with an average CV in speed of 3.4%.CONCLUSION: The fastest STT was characterized by more aggressive pacing and a greater anaerobic energy production. Although the individual performance time during the four STTs was highly consistent, the small within-athlete variability in performance was related to variations in anaerobic energy production.
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| 9. |
- Andersson, Erik, 1984-, et al.
(author)
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Energy system contributions and determinants of performance in sprint cross-country skiing
- 2017
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In: Scandinavian Journal of Medicine and Science in Sports. - : Wiley. - 0905-7188 .- 1600-0838. ; 27:4, s. 385-398
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Journal article (peer-reviewed)abstract
- To improve current understanding of energy contributions and determinants of sprint-skiing performance, 11 well-trained male cross-country skiers were tested in the laboratory for VO2max , submaximal gross efficiency (GE), maximal roller skiing velocity, and sprint time-trial (STT) performance. The STT was repeated four times on a 1300-m simulated sprint course including three flat (1°) double poling (DP) sections interspersed with two uphill (7°) diagonal stride (DS) sections. Treadmill velocity and VO2 were monitored continuously during the four STTs and data were averaged. Supramaximal GE during the STT was predicted from the submaximal relationships for GE against velocity and incline, allowing computation of metabolic rate and O2 deficit. The skiers completed the STT in 232 ± 10 s (distributed as 55 ± 3% DP and 45 ± 3% DS) with a mean power output of 324 ± 26 W. The anaerobic energy contribution was 18 ± 5%, with an accumulated O2 deficit of 45 ± 13 mL/kg. Block-wise multiple regression revealed that VO2 , O2 deficit, and GE explained 30%, 15%, and 53% of the variance in STT time, respectively (all P < 0.05). This novel GE-based method of estimating the O2 deficit in simulated sprint-skiing has demonstrated an anaerobic energy contribution of 18%, with GE being the strongest predictor of performance.
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| 10. |
- Andersson, Erik, 1984-, et al.
(author)
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Metabolic responses and pacing strategies during successive sprint skiing time trials
- 2016
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In: Medicine & Science in Sports & Exercise. - 0195-9131 .- 1530-0315. ; 48:12, s. 2544-2554
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Journal article (peer-reviewed)abstract
- PURPOSE: To examine the metabolic responses and pacing strategies during the performance of successive sprint time trials (STTs) in cross-country skiing. METHODS: Ten well-trained male cross-country skiers performed four self-paced 1300-m STTs on a treadmill, each separated by 45 min of recovery. The simulated STT course was divided into three flat (1°) sections (S1, S3 and S5) involving the double poling sub-technique interspersed with two uphill (7°) sections (S2 and S4) involving the diagonal stride sub-technique. Treadmill velocity and V˙O2 were monitored continuously and gross efficiency was used to estimate the anaerobic energy supply. RESULTS: The individual trial-to-trial variability in STT performance time was 1.3%, where variations in O2 deficit and V˙O2 explained 69% (P < 0.05) and 11% (P > 0.05) of the variation in performance. The first and last STTs were equally fast (228 ± 10 s), and ~ 1.3% faster than the second and the third STTs (P < 0.05). These two fastest STTs were associated with a 14% greater O2 deficit (P < 0.05), while the average V˙O2 was similar during all four STTs (86 ± 3% of V˙O2max). Positive pacing was used throughout all STTs, with significantly less time spent on the first than second course half. In addition, metabolic rates were substantially higher (~_30%) for uphill than for flat skiing, indicating that pacing was regulated to the terrain. CONCLUSIONS: The fastest STTs were characterized primarily by a greater anaerobic energy production, which also explained 69% of the individual variation in performance. Moreover, the skiers employed positive pacing and a variable exercise intensity according to the course profile, yielding an irregular distribution of anaerobic energy production.
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