| 1. |
- Askling, Helena H, et al.
(author)
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Serologic Analysis of Returned Travelers with Fever, Sweden
- 2009
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In: Emerging Infectious Diseases. - Atlanta, GA, USA : U.S. Department of Health and Human Services * Centers for Disease Control and Prevention. - 1080-6040 .- 1080-6059. ; 15:11, s. 1805-1808
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Journal article (peer-reviewed)abstract
- We studied 1,432 febrile travelers from Sweden who had returned from malaria-endemic areas during March 2005-March 2008. In 383 patients, paired serum samples were blindly analyzed for influenza and 7 other agents. For 21% of 115 patients with fever of unknown origin, serologic analysis showed that influenza was the major cause.
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| 2. |
- Hommel, Ami, et al.
(author)
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Influence of optimised treatment of people with hip fracture on time to operation, length of hospital stay, reoperations and mortality within 1 year
- 2008
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In: Injury. - : Elsevier. - 0020-1383 .- 1879-0267. ; 39:10, s. 1164-1174
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Journal article (peer-reviewed)abstract
- Hip fractures are a major cause of hospital stay among the elderly, and result in increased disability and mortality. In this study from 1 April 2003 to 31 March 2004, the influence of optimised treatment of hip fracture on time to operation, length of hospital stay, reoperations and mortality within 1 year were investigated. Comparisons were made between the first 210 patients in the period and the last 210 patients, who followed the new clinical pathway introduced at the University Hospital in Lund, Sweden. Early surgery, within 24h, was not associated with reduced mortality, but was significantly associated with reduced length of stay (p<0.001). Significantly more cases of osteosynthesis for femoral neck fracture were reoperated compared with all other types of surgery (p<0.001) when reoperations with extraction of the hook pins in healed fractures were excluded. Mortality was significantly higher among men than women at 4 (p=0.025) and 12 (p=0.001) months after fracture and among medically fit patients with administrative delay to surgery compared with patients with no delay (p<0.001).
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| 3. |
- Hultberg, Tove, et al.
(author)
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The late-Holocene decline of Tilia in relation to climate and human activities - pollen evidence from 42 sites in southern Sweden
- 2017
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In: Journal of Biogeography. - : Wiley. - 0305-0270 .- 1365-2699. ; 44:10, s. 2398-2409
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Journal article (peer-reviewed)abstract
- Aim: The dominant role of Tilia in primeval forests of Scandinavia has long been recognized, but the timing and mechanisms for its decline have not been completely unravelled. A particular uncertainty involves the balance between climate and human activities as the drivers of the change. One reason for the uncertainty is the challenge in evaluating the past cover of the genus owing to its poorly dispersed pollen; another is that a multi-site study would be required to trace subregional differences. To overcome these obstacles, we here apply two different analytical methods to pollen data from 42 sites in two distinct vegetation zones of Sweden. Location: Temperate and hemi-boreal vegetation zones of southern Sweden. Methods: Generalized additive mixed models (GAMM) were used to model the development of Tilia and cereal pollen percentages over time. Twelve sites were used for reconstruction of local cover of Tilia using the landscape reconstruction algorithm (LRA). Results: Before 4000 cal. bp the Tilia mean pollen percentages were similar in the two vegetation zones. Thereafter, values in the hemi-boreal zone declined, with less Tilia since around 3000 cal. bp. In contrast, Tilia did not decrease in the temperate zone until this past millennium. The LRA application revealed that in some forests a large cover of Tilia remained considerably longer than has traditionally been estimated by pollen percentages alone. Main conclusions: By using a large coherent dataset we found significant differences in how the abundance and distribution of Tilia changed through time between two adjacent vegetation zones. We interpret the initial decline in the northern hemi-boreal zone to be driven by cooling climate, and the later decline in the southern temperate zone to be driven more by human land-use.
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| 4. |
- Källberg, Eva, et al.
(author)
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S100A9 Interaction with TLR4 Promotes Tumor Growth
- 2012
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In: PLOS ONE. - San Francisco : Public Library of Science. - 1932-6203. ; 7:3, s. e34207-
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Journal article (peer-reviewed)abstract
- By breeding TRAMP mice with S100A9 knock-out (S100A9(-/-)) animals and scoring the appearance of palpable tumors we observed a delayed tumor growth in animals devoid of S100A9 expression. CD11b(+) S100A9 expressing cells were not observed in normal prostate tissue from control C57BL/6 mice but were readily detected in TRAMP prostate tumors. Also, S100A9 expression was observed in association with CD68(+) macrophages in biopsies from human prostate tumors. Delayed growth of TRAMP tumors was also observed in mice lacking the S100A9 ligand TLR4. In the EL-4 lymphoma model tumor growth inhibition was observed in S100A9(-/-) and TLR4(-/-), but not in RAGE(-/-) animals lacking an alternative S100A9 receptor. When expression of immune-regulating genes was analyzed using RT-PCR the only common change observed in mice lacking S100A9 and TLR4 was a down-regulation of TGF beta expression in splenic CD11b(+) cells. Lastly, treatment of mice with a small molecule (ABR-215050) that inhibits S100A9 binding to TLR4 inhibited EL4 tumor growth. Thus, S100A9 and TLR4 appear to be involved in promoting tumor growth in two different tumor models and pharmacological inhibition of S100A9-TLR4 interactions is a novel and promising target for anti-tumor therapies.
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| 5. |
- Reepalu, Anton, et al.
(author)
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Development of an algorithm for determination of the likelihood of virological failure in HIV-positive adults receiving antiretroviral therapy in decentralized care
- 2017
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In: Global Health Action. - : Informa UK Limited. - 1654-9716 .- 1654-9880. ; 10:1
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Journal article (peer-reviewed)abstract
- Background: Early identification of virological failure (VF) limits occurrence and spread of drug-resistant viruses in patients receiving antiretroviral treatment (ART). Viral load (VL) monitoring is therefore recommended, but capacities to comply with this are insufficient in many low-income countries. Clinical algorithms might identify persons at higher likelihood of VF to allocate VL resources. Objectives: We aimed to construct a VF algorithm (the Viral Load Testing Criteria; VLTC) and compare its performance to the 2013 WHO treatment failure criteria. Methods: Subjects with VL results available 1 year after ART start (n = 494) were identified from a cohort of ART-naïve adults (n = 812), prospectively recruited and followed 2011-2015 at Ethiopian health centres. VF was defined as VL≥1000 copies/mL. Variables recorded at the time of sampling, with potential association with VF, were used to construct the algorithm based on multivariate logistic regression. Results: Fifty-seven individuals (12%) had VF, which was independently associated with CD4 count <350 cells/mm3, previous ART interruption, and short mid-upper arm circumference (<24cm and <23cm, for men and women, respectively). These variables were included in the VLTC. In derivation, the VLTC identified 52/57 with VF; sensitivity 91%, specificity 43%, positive predictive value (PPV) 17%, negative predictive value (NPV) 97%. In comparison, the WHO criteria identified 38/57 with VF (sensitivity 67%, specificity 74%, PPV 25%, NPV 94%). Conclusions: The VLTC identified subjects at greater likelihood of VF, with higher sensitivity and NPV than the WHO criteria. If external validation confirms this performance, these criteria could be used to allocate limited VL resources. Due to its limited specificity, it cannot be used to determine treatment failure in the absence of a confirmatory viral load.
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| 6. |
- Tesfaye, Fregenet, et al.
(author)
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Alternative biomarkers for classification of latent tuberculosis infection status in pregnant women with borderline Quantiferon plus results
- 2020
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In: Tuberculosis. - : Elsevier BV. - 1472-9792. ; 124
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Journal article (peer-reviewed)abstract
- Borderline interferon-gamma (IFN-γ) results (near the cut-off level 0.35 IU/ml) occur in QuantiFERON (QFT) assays. We investigated the performance of alternative biomarkers for classification of latent tuberculosis infection (LTBI) status in pregnant women with borderline QFT IFN-γ responses. Pregnant women (n = 96) were identified from a cohort study in Ethiopia, based on QFT-Plus IFN-γ results (QFT-low: <0.20 IU/ml, n = 33; QFT-borderline: 0.20–0.70 IU/ml, n = 31; QFT-high: >0.70 IU/ml, n = 32), including 12 HIV-positive individuals in each group and with 20 HIV-negative non-pregnant women from the same cohort with QFT IFN-γ <0.20 IU/ml as controls. Concentrations of 8 markers (IL-1ra, IL-6, IL-8, IP-10, MCP-1, MCP-2, osteopontin and resistin) were measured in whole blood QFT supernatants, stimulated separately with TB1 and TB2 antigens. K-nearest neighbor analysis (KNN) was used to classify participants with regard to likelihood of LTBI. Concentrations of MCP-2, IP-10 and IL-1ra were higher in QFT-borderline compared to QFT-low participants in both antigen stimulations (p < 0.001). KNN classification indicated high likelihood of LTBI in 13/31 (42%) women with QFT-borderline IFN-γ results. MCP-2, IP-10 and IL-1ra expressed in whole blood after TB antigen stimulation may be considered as alternative biomarkers for classification of LTBI status in pregnant women with borderline QFT IFN-γ results.
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| 7. |
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31 recommendations for increased profit - reducing waste
- 2010
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Reports (other academic/artistic)abstract
- Those companies and organizations that wish to ensure long-term profitability must successively decrease resource use in both product development and in product usage. Primarily, it is waste that must be reduced, i.e. the consumption of resources that do not add to customer value or to the organization. Waste is widespread in all operations. Even in well-functioning processes, more than half of the resource consumption can be classified as waste. One obstacle to waste elimination is that most waste is hidden. Thus, executives, middle management and specialists must prioritize efforts to uncover the waste in their operations.Building and construction activities consist of a complex system of decisions, components, organizations and processes that must be coordinated. There are therefore many explanations as to why waste arises, or does not. Based on a series of discussions with experienced builders, consultants, contractors and materials providers, five main groups of factors that characterize effective operations were found. In this report these factors are illustrated in the form of a “value pyramid”. A holistic view of long-term customer benefits is the apex of the pyramid. Structure, competence, leadership and culture act as the driving forces at each corner of the pyramid’s foundation. Should one of the corners gives way, then the pyramid risks toppling over.With the value pyramid as support, 31 recommendations for what should be done to reduce waste are presented. These are aimed at standardizing the product from an overall perspective (five recommendations), defining and standardizing processes (ten recommendations), developing the organization and its competence (seven recommendations), disciplining management (five recommendations), and driving continuous improvement work (four recommendations). Reducing uncertainties and increasing effective time utilization are the red threads, as the Swedes would say, that run through all the recommendations.Everyone who uses resources has a responsibility to reduce waste. By systematically monitoring one’s own use of time, one can gain insights that will help improve one’s work situation. However, the burden of initiating and driving improvements overall obviously lies with management. How this should be done depends on the nature and purpose of the activities as well as on the organization’s capabilities. It is to manage this progress and achieve profitability that managers are appointed. It is in the interest of all enterprises and organizations to develop the ability and an interest to detect and understand what work/task is value adding what is not. This ability will provide possibilities to develop new competitive advantages and new business concepts.
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| 8. |
- Adman, Per, 1970-
(author)
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Arbetslöshet, arbetsplatsdemokrati och politiskt deltagande
- 2004
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Doctoral thesis (other academic/artistic)abstract
- The purpose of this thesis is to test two hypotheses about how work affects political participation. The first concerns unemployment, and states that unemployment has strong and negative effects on political activity. The second hypothesis is found in theories of participatory democracy, and claims that more democratic workplaces lead to more political participation. Existing empirical evidence on both of the hypotheses is not conclusive. Furthermore, studies have mainly been carried out using data collected in the United States. Here empirical tests of the hypotheses are undertaken using a Swedish survey.The results confirm the first hypothesis; unemployment has negative effects on political participation. The reasons for these negative effects are that the unemployed become less active in organisational life, fall outside of the recruitment networks where people are being asked to participate in politics, and experience a decrease in income. The second hypothesis is not supported. Workplace participation does not affect political participation, according to the analyses. The results are surprising for both hypotheses, and contradict previous empirical findings. The differences in results are likely due to differences in research design and differences in approaches to analysing political participation. Previous studies are inadequate in these perspectives, it is maintained.The thesis ends with a discussion of the results from the perspective of normative democratic theory. It is argued that the lack of political equality is particularly acute when the low participation among the unemployed is considered.
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| 9. |
- Ahlgren, Bengt, et al.
(author)
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Integrated layer processing can be hazardous to your performance
- 1997. - 1
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Conference paper (peer-reviewed)abstract
- Integrated Layer Processing (ILP) has been presented as an implementation technique to improve communication protocol performance by reducing the number of memory references. Previous research has however not pointed out that in some circumstances ILP can significantly increase the number of memory references, resulting in lower communication throughput. We explore the performance effects of applying ILP to data manipulation functions with varying characteristics. The functions are generated from a set of parameters including input and output block size, state size and number of instructions. We present experimental data for varying function state sizes, number of integrated functions and instruction counts. The results clearly show that the aggregated state of the functions must fit in registers for ILP to be competitive.
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| 10. |
- Ahlgren, Bengt, et al.
(author)
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The applicability of integrated layer processing
- 1998. - 4
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In: IEEE Journal on Selected Areas in Communications. ; 16:3, s. 317-331
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Journal article (peer-reviewed)abstract
- In this paper we review previous work on the applicability and performance of Integrated Layer Processing (ILP). ILP has been shown to clearly improve computer communication performance when integrating simple data manipulation functions, but the situation has been less clear for more complex functions and complete systems. We discuss complications when applying ILP to protocol stacks, the requirements of ILP on the communication subsystem, caching aspects, the importance of the processor registers, and a model for predicting the performance of data manipulation functions. We conclude that the main drawback of ILP is its limited aplicability to complex data manipulation functions. The performance to expect from an ILP implementation also depends heavily on the protocol architecture and the host system architecture.
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