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Stimulating brain r...
Stimulating brain recovery after stroke using theranostic albumin nanocarriers loaded with nerve growth factor in combination therapy
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- Feczkó, Tivadar (författare)
- Research Centre for Natural Sciences of the Hungarian Academy of Sciences,University Hospital Frankfurt,University of Pannonia
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- Piiper, Albrecht (författare)
- University Hospital Frankfurt
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- Ansar, Saema (författare)
- Lund University,Lunds universitet,Experimentell kärlforskning,Forskargrupper vid Lunds universitet,Experimental Vascular Research,Lund University Research Groups
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- Blixt, Frank W. (författare)
- Lund University,Lunds universitet,Experimentell kärlforskning,Forskargrupper vid Lunds universitet,Experimental Vascular Research,Lund University Research Groups
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- Ashtikar, Mukul (författare)
- Fraunhofer Institute for Molecular Biology and Applied Ecology
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- Schiffmann, Susanne (författare)
- Fraunhofer Institute for Molecular Biology and Applied Ecology
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- Ulshöfer, Thomas (författare)
- Fraunhofer Institute for Molecular Biology and Applied Ecology
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- Parnham, Michael J. (författare)
- Fraunhofer Institute for Molecular Biology and Applied Ecology
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- Harel, Yifat (författare)
- Bar-Ilan University
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- Israel, Liron Limor (författare)
- Bar-Ilan University
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- Lellouche, Jean Paul (författare)
- Bar-Ilan University
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- Wacker, Matthias G. (författare)
- Goethe University,Fraunhofer Institute for Molecular Biology and Applied Ecology
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(creator_code:org_t)
- Elsevier BV, 2019
- 2019
- Engelska 10 s.
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Ingår i: Journal of Controlled Release. - : Elsevier BV. - 0168-3659. ; 293, s. 63-72
- Relaterad länk:
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http://dx.doi.org/10...
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http://real.mtak.hu/...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- For many years, delivering drug molecules across the blood brain barrier has been a major challenge. The neuropeptide nerve growth factor is involved in the regulation of growth and differentiation of cholinergic neurons and holds great potential in the treatment of stroke. However, as with many other compounds, the biomolecule is not able to enter the central nervous system. In the present study, nerve growth factor and ultra-small particles of iron oxide were co-encapsulated into a chemically crosslinked albumin nanocarrier matrix which was modified on the surface with apolipoprotein E. These biodegradable nanoparticles with a size of 212 ± 1 nm exhibited monodisperse size distribution and low toxicity. They delivered NGF through an artificial blood brain barrier and were able to induce neurite outgrowth in PC12 cells in vitro. In an animal model of stroke, the infarct size was significantly reduced compared to the vehicle control. The combination therapy of NGF and the small-molecular MEK inhibitor U0126 showed a slight but not significant difference compared to U0126 alone. However, further in vivo evidence suggests that successful delivery of the neuropeptide is possible as well as the synergism between those two treatments.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Nyckelord
- BBB
- Brain
- Drug delivery
- MEK
- Nanoparticles
- NGF
- Theranostic
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Feczkó, Tivadar
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Piiper, Albrecht
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Ansar, Saema
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Blixt, Frank W.
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Ashtikar, Mukul
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Schiffmann, Susa ...
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visa fler...
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Ulshöfer, Thomas
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Parnham, Michael ...
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Harel, Yifat
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Israel, Liron Li ...
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Lellouche, Jean ...
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Wacker, Matthias ...
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