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Search: WFRF:(Blixt Martin) > Natural sciences

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1.
  • Goel, Suchi, et al. (author)
  • RIFINs are adhesins implicated in severe Plasmodium falciparum malaria
  • 2015
  • In: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 21:4, s. 314-317
  • Journal article (peer-reviewed)abstract
    • Rosetting is a virulent Plasmodium falciparum phenomenon associated with severe malaria. Here we demonstrate that P. falciparum-encoded repetitive interspersed families of polypeptides (RIFINs) are expressed on the surface of infected red blood cells (iRBCs), bind to RBCs-preferentially of blood group A-to form large rosettes and mediate microvascular binding of iRBCs. We suggest that RIFINs have a fundamental role in the development of severe malaria and thereby contribute to the varying global distribution of ABO blood groups in the human population.
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2.
  • Tobola, Felix, et al. (author)
  • Engineering the Ligand Specificity of the Human Galectin-1 by Incorporation of Tryptophan Analogues
  • 2022
  • In: ChemBioChem. - : Wiley. - 1439-4227 .- 1439-7633. ; 23:5
  • Journal article (peer-reviewed)abstract
    • Galectin-1 is a β-galactoside-binding lectin with manifold biological functions. A single tryptophan residue (W68) in its carbohydrate binding site plays a major role in ligand binding and is highly conserved among galectins. To fine tune galectin-1 specificity, we introduced several non-canonical tryptophan analogues at this position of human galectin-1 and analyzed the resulting variants using glycan microarrays. Two variants containing 7-azatryptophan and 7-fluorotryptophan showed a reduced affinity for 3’-sulfated oligosaccharides. Their interaction with different ligands was further analyzed by fluorescence polarization competition assay. Using molecular modeling we provide structural clues that the change in affinities comes from modulated interactions and solvation patterns. Thus, we show that the introduction of subtle atomic mutations in the ligand binding site of galectin-1 is an attractive approach for fine-tuning its interactions with different ligands.
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3.
  • Watz, Johan, 1977-, et al. (author)
  • Atlantic salmon in regulated rivers: Understanding river management through the ecosystem services lens
  • 2022
  • In: Fish and Fisheries. - : John Wiley & Sons. - 1467-2960 .- 1467-2979. ; 23:2, s. 478-491
  • Journal article (peer-reviewed)abstract
    • Known as the “king of fishes”, the Atlantic salmon (Salmo salar, Salmonidae) is an iconic freshwater species whose contribution to human wellbeing has long been recognized, as have widespread declines in its abundance, partly due to river regulation. To understand how salmon conservation has been addressed within the ecosystem services (ES) framework, we synthesized the peer-reviewed literature on ES provided by salmon in regulated rivers. We developed a search string to capture allusions to provisioning, regulating, supporting and cultural ES and assessed the results to identify knowledge gaps. The effects of hydropower on fisheries catches and on modelled populations were shown is several publications. Overall, few studies focused explicitly on ES from salmon and hydropower; this is surprising given the considerable body of literature on salmon in regulated rivers. Wild salmon as a food source and other provisioning services are less important today than historically. Because predators such as salmon are important for facilitating biodiversity by cycling nutrients and controlling food webs, there is a scope of work for future assessments of these regulating and supporting services. Few papers explicitly addressed cultural ES, despite the salmon’s longstanding iconic status; this is a knowledge gap for future ES assessments in relation to hydropower. The influence of ES assessments for policy makers is growing through the Intergovernmental Panel for Biodiversity and Ecosystem Services (IPBES) and the post-2020 biodiversity strategy. Explicitly addressing ES poses an opportunity for river managers to raise awareness of aquatic conservation efforts and well-informed decision-making for sustaining ES.
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