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Träfflista för sökning "WFRF:(Bogdanova Natalia) srt2:(2010-2014);conttype:(refereed)"

Sökning: WFRF:(Bogdanova Natalia) > (2010-2014) > Refereegranskat

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1.
  • Kirchhoff, Tomas, et al. (författare)
  • Breast cancer risk and 6q22.33 : combined results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2
  • 2012
  • Ingår i: PLOS ONE. - : Public library of science. - 1932-6203. ; 7:6
  • Tidskriftsartikel (refereegranskat)abstract
    • Recently, a locus on chromosome 6q22.33 (rs2180341) was reported to be associated with increased breast cancer risk in the Ashkenazi Jewish (AJ) population, and this association was also observed in populations of non-AJ European ancestry. In the present study, we performed a large replication analysis of rs2180341 using data from 31,428 invasive breast cancer cases and 34,700 controls collected from 25 studies in the Breast Cancer Association Consortium (BCAC). In addition, we evaluated whether rs2180341 modifies breast cancer risk in 3,361 BRCA1 and 2,020 BRCA2 carriers from 11 centers in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Based on the BCAC data from women of European ancestry, we found evidence for a weak association with breast cancer risk for rs2180341 (per-allele odds ratio (OR) = 1.03, 95% CI 1.00-1.06, p = 0.023). There was evidence for heterogeneity in the ORs among studies (I(2) = 49.3%; p = <0.004). In CIMBA, we observed an inverse association with the minor allele of rs2180341 and breast cancer risk in BRCA1 mutation carriers (per-allele OR = 0.89, 95%CI 0.80-1.00, p = 0.048), indicating a potential protective effect of this allele. These data suggest that that 6q22.33 confers a weak effect on breast cancer risk.
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2.
  • Lubnina, Natalia V., et al. (författare)
  • A new key pole for the East European Craton at 1452 Ma: Palaeomagnetic and geochronological constraints from mafic rocks in the Lake Ladoga region (Russian Karelia)
  • 2010
  • Ingår i: Precambrian Research. - : Elsevier BV. - 0301-9268. ; 183:3, s. 442-462
  • Tidskriftsartikel (refereegranskat)abstract
    • Palaeomagnetic and geochronological studies on mafic rocks in the Lake Ladoga region in South Russian Karelia provide a new, reliably dated Mesoproterozoic key paleopole for the East European Craton (Baltica). U-Pb dating on baddeleyite gives a crystallisation age of 1452 +/- 12 Ma for one of the studied dolerite dykes. A mean palaeomagnetic pole for the Mesoproterozoic dolerite dykes. Valaam sill and Salmi basalts yields a paleopole at 15.2 degrees N, 177.1 degrees E, A(95) = 5.5 degrees. Positive baked contact test for the dolerite dykes and positive reversal test for the Salmi basalts and for the dykes confirm the primary nature of the magnetisation. Comparison of this Baltica palaeopole with coeval paleomagnetic data for Laurentia and Siberia provides a revised palaeoposition of these cratons. The results verify that the East European Craton, Laurentia and Siberia were part of the supercontinent Columbia from the Late Palaeoproterozoic to the Middle Neoproterozoic. (C) 2010 Elsevier B.V. All rights reserved.
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