Evidence for two types of brown adipose tissue in humans

• The previously observed supraclavicular depot of brown adipose tissue (BAT) in adult humans was commonly believed to be the equivalent of the interscapular thermogenic organ of small mammals. This view was recently disputed on the basis of the demonstration that this depot consists of beige (also called brite) brown adipocytes, a newly identified type of brown adipocyte that is distinct from the classical brown adipocytes that make up the interscapular thermogenic organs of other mammals. A combination of high-resolution imaging techniques and histological and biochemical analyses showed evidence for an anatomically distinguishable interscapular BAT (iBAT) depot in human infants that consists of classical brown adipocytes, a cell type that has so far not been shown to exist in humans. On the basis of these findings, we conclude that infants, similarly to rodents, have the bona fide iBAT thermogenic organ consisting of classical brown adipocytes that is essential for the survival of small mammals in a cold environment.

Ämnesord

Medical and Health Sciences  (hsv)

Basic Medicine  (hsv)

Medical Genetics  (hsv)

Medicin och hälsovetenskap  (hsv)

Medicinska grundvetenskaper  (hsv)

Medicinsk genetik  (hsv)

Cell and Molecular Biology  (hsv)

Cell- och molekylärbiologi  (hsv)

Engineering and Technology  (hsv)

Medical Engineering  (hsv)

Medical Image Processing  (hsv)

Teknik och teknologier  (hsv)

Medicinteknik  (hsv)

Medicinsk bildbehandling  (hsv)

Clinical Medicine  (hsv)

Radiology, Nuclear Medicine and Medical Imaging  (hsv)

Klinisk medicin  (hsv)

Radiologi och bildbehandling  (hsv)

Nyckelord

BAT

MRI