| 1. |
- Law, Andrew M. K., et al.
(författare)
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ALTEN: A High‐Fidelity Primary Tissue‐Engineering Platform to Assess Cellular Responses Ex Vivo
- 2022
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Ingår i: Advanced Science. - : John Wiley & Sons. - 2198-3844. ; 9:21
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Tidskriftsartikel (refereegranskat)abstract
- To fully investigate cellular responses to stimuli and perturbations within tissues, it is essential to replicate the complex molecular interactions within the local microenvironment of cellular niches. Here, the authors introduce Alginate-based tissue engineering (ALTEN), a biomimetic tissue platform that allows ex vivo analysis of explanted tissue biopsies. This method preserves the original characteristics of the source tissue's cellular milieu, allowing multiple and diverse cell types to be maintained over an extended period of time. As a result, ALTEN enables rapid and faithful characterization of perturbations across specific cell types within a tissue. Importantly, using single-cell genomics, this approach provides integrated cellular responses at the resolution of individual cells. ALTEN is a powerful tool for the analysis of cellular responses upon exposure to cytotoxic agents and immunomodulators. Additionally, ALTEN's scalability using automated microfluidic devices for tissue encapsulation and subsequent transport, to enable centralized high-throughput analysis of samples gathered by large-scale multicenter studies, is shown.
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| 2. |
- Kerrouche, A., et al.
(författare)
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Field tests of fibre Bragg grating sensors incorporated into CFRP for railway bridge strengthening condition monitoring
- 2008
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Ingår i: Sensors and Actuators A-Physical. - : Elsevier BV. - 0924-4247 .- 1873-3069. ; 148:1, s. 68-74
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Tidskriftsartikel (refereegranskat)abstract
- The EU is in the process of upgrading the national railway networks to meet the demands from high-speed passenger trains and heavy Freight traffic. This upgrade necessitates a review of the development and implementation of novel technologies to repair and strengthen the existing bridge structures and to improve their performance.This paper presents the evaluation results of the use of FBG strains sensors incorporated in CFRP (carbon fibre reinforcement polymer) rods and tubes as part of the methodology for monitoring the performance of the NSMR (near surface mounted reinforcement) which is an essential part of the repair and strengthening of bridges. In addition, a new method has been tested for the first time using CFRP tubes which calls for the drilling of holes instead of sawing grooves in the installation process.The paper discusses in some detail the strengthening mechanism, FBG sensor implementation and the electronic system used to interrogate the FBG sensors. The results obtained from the monitoring show that FBG sensors can be integrated into CFRP and that reliable measurements can be made. However, in this particular project, the strain loading is very moderate so consequently the strain levels are in the elastic regime.
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