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Cladribine prolongs...
Cladribine prolongs progression-free survival and time to second treatment compared to fludarabine and high-dose chlorambucil in chronic lymphocytic leukemia
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- Mulligan, Stephen P (författare)
- Department of Haematology, Royal North Shore Hospital, St LeonardsSydney, NSW, Australia
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- Karlsson, Karin (författare)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Department of Hematology, Skåne University Hospital, Lund , Sweden
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- Strömberg, Mats (författare)
- Department of Oncology, Karolinska University Hospital, Stockholm, Sweden
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- Jønsson, Viggo (författare)
- Department of Hematology, National Hospital, Copenhagen, Denmark
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- Gill, Devinder (författare)
- Department of Haematology, Princess Alexandra Hospital, Brisbane, Australia
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- Hammerström, Jens (författare)
- Department of Hematology, St Olav University Hospital, Trondheim, Norway
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- Hertzberg, Mark (författare)
- Department of Haematology, Westmead Hospital, Sydney, Australia
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- McLennan, Roger (författare)
- Department of Haematology, Ballarat Base Hospital, Ballarat, Australia
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- Uggla, Bertil, 1962- (författare)
- Region Örebro län,Department of Medicine, Örebro University Hospital, Örebro, Sweden
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- Norman, John (författare)
- Department of Haematology, Royal Adelaide Hospital, Adelaide, Australia
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- Wallvik, Jonas (författare)
- Department of Medicine, Region Västernorrland County Hospital, Sundsvall, Sweden,Sundsvall Research Unit, Umeå University,Department Med, Sweden
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- Sundström, Gunnel (författare)
- Department of Hematology, Norrlands University Hospital, Umeå, Sweden
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- Johansson, Hemming (författare)
- Karolinska Institutet
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- Brandberg, Yvonne (författare)
- Karolinska Institutet
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- Liliemark, Jan (författare)
- Department of Oncology, Karolinska University Hospital, Stockholm, Sweden; Swedish Council on Health Technology Assessment, Stockholm, Sweden
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- Juliusson, Gunnar (författare)
- Östergötlands Läns Landsting,Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Hematologiska kliniken US,Department of Hematology, Sk å ne University Hospital, Lund, Sweden
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(creator_code:org_t)
- 2014-04-16
- 2014
- Engelska.
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Ingår i: Leukemia and Lymphoma. - : Informa Healthcare. - 1042-8194 .- 1029-2403. ; 55:12, s. 2769-2777
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- We conducted a randomized phase III trial to compare the efficacy and safety of two purine analogs, cladribine and fludarabine, with high-dose chlorambucil, in patients with previously untreated chronic lymphocytic leukemia (CLL). Between 1997 and 2004, 223 patients with CLL were randomly assigned to cladribine, fludarabine or chlorambucil, for six cycles of therapy with frequent health-related quality of life assessments. There was no statistical difference for the primary endpoint of overall response with cladribine (70%), fludarabine (67%) and chlorambucil (59%), or complete remission (12%, 7% and 8%), respectively. However, the median progression-free survival (25, 10, 9 months) and median time to second treatment (40, 22, 21 months) were superior with cladribine. There was no significant difference in overall survival (96, 82 and 91 months), nor in toxicity or HRQoL assessments. Monotherapy with cladribine gives superior PFS and longer response duration than fludarabine and chlorambucil as first-line treatment of CLL.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- Lymphoid leukemia
- chemotherapeutic approaches
- pharmacotherapeutics
- CLL
- Onkologi
- Oncology
- Lymphoid leukemia
- chemotherapeutic approaches
- pharmacotherapeutics
- CLL
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Mulligan, Stephe ...
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Karlsson, Karin
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Strömberg, Mats
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Jønsson, Viggo
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Gill, Devinder
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Hammerström, Jen ...
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Hertzberg, Mark
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McLennan, Roger
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Uggla, Bertil, 1 ...
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Norman, John
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Wallvik, Jonas
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Sundström, Gunne ...
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Johansson, Hemmi ...
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Brandberg, Yvonn ...
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Liliemark, Jan
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Juliusson, Gunna ...
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