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Asymmetric thinning...
Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer’s disease
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- Roe, James M. (author)
- Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
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- Vidal-Piñeiro, Didac (author)
- Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
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- Sørensen, Øystein (author)
- Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
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- Brandmaier, Andreas M. (author)
- Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany
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- Düzel, Sandra (author)
- Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany
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- Gonzalez, Hector A. (author)
- Center for Vital Longevity, University of Texas, TX, Dallas, United States
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- Kievit, Rogier A. (author)
- MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, United Kingdom
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- Knights, Ethan (author)
- MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, United Kingdom
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- Kühn, Simone (author)
- Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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- Lindenberger, Ulman (author)
- Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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- Mowinckel, Athanasia M. (author)
- Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
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- Nyberg, Lars, 1966- (author)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI)
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- Park, Denise C. (author)
- Center for Vital Longevity, University of Texas, TX, Dallas, United States
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- Pudas, Sara, Fil. Dr. 1983- (author)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI)
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- Rundle, Melissa M. (author)
- Center for Vital Longevity, University of Texas, TX, Dallas, United States
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- Walhovd, Kristine B. (author)
- Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway
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- Fjell, Anders M. (author)
- Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway
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- Westerhausen, René (author)
- Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
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(creator_code:org_t)
- 2021-02-01
- 2021
- English.
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In: Nature Communications. - : Nature Research. - 2041-1723. ; 12:1
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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Abstract
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- Aging and Alzheimer’s disease (AD) are associated with progressive brain disorganization. Although structural asymmetry is an organizing feature of the cerebral cortex it is unknown whether continuous age- and AD-related cortical degradation alters cortical asymmetry. Here, in multiple longitudinal adult lifespan cohorts we show that higher-order cortical regions exhibiting pronounced asymmetry at age ~20 also show progressive asymmetry-loss across the adult lifespan. Hence, accelerated thinning of the (previously) thicker homotopic hemisphere is a feature of aging. This organizational principle showed high consistency across cohorts in the Lifebrain consortium, and both the topological patterns and temporal dynamics of asymmetry-loss were markedly similar across replicating samples. Asymmetry-change was further accelerated in AD. Results suggest a system-wide dedifferentiation of the adaptive asymmetric organization of heteromodal cortex in aging and AD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
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- ref (subject category)
- art (subject category)
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Roe, James M.
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Vidal-Piñeiro, D ...
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Sørensen, Øystei ...
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Brandmaier, Andr ...
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Düzel, Sandra
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Gonzalez, Hector ...
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Kievit, Rogier A ...
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Knights, Ethan
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Kühn, Simone
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Lindenberger, Ul ...
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Mowinckel, Athan ...
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Nyberg, Lars, 19 ...
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Park, Denise C.
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Pudas, Sara, Fil ...
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Rundle, Melissa ...
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Walhovd, Kristin ...
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Fjell, Anders M.
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Westerhausen, Re ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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Nature Communica ...
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Umeå University