| 1. |
- Maraste, Rauni, et al.
(författare)
-
Anxiety and depression in breast cancer patients at start of adjuvant radiotherapy : Relations to age and type of surgery
- 1992
-
Ingår i: Acta Oncologica. - : Informa UK Limited. - 0284-186X .- 1651-226X. ; 31:6, s. 641-643
-
Tidskriftsartikel (refereegranskat)abstract
- Using a self-report questionnaire, the Hospital Anxiety and Depression (HAD) scale, feelings of anxiety and depression were assessed in 133 breast cancer patients referred for adjuvant radiotherapy following surgical treatment. Eighteen patients (14% had scores indicating morbid anxiety. Significant depression was recorded for only 2 patients (1.5% Severe anxiety was recorded for 10 out of 54 mastectomized patients (19% and for 8 out of 79 patients treated with breast conserving surgery (10% The difference was not significant (p = 0.13). In a subgroup aged 50-59 years, morbid anxiety was significantly more common among mastectomized patients than among patients operated conservatively, 4 out of 9 (44% vs. 1 out of 23 (4% (p = 0.01). Such a pattern was not discernable in the patients <50 years of age or those ≥ 60 years old. The results suggest that, at start of adjuvant radiotherapy, emotional distress is characterized by anxiety rather than depression and the risk of morbid anxiety is especially large for mastectomized women in their fifties.
|
|
| 2. |
- Brandt, Lars, et al.
(författare)
-
Proliferative activity and number of clonal chromosome aberrations in non‐Hodgkin's lymphomas
- 1986
-
Ingår i: Scandinavian Journal of Haematology. - : Wiley. - 0036-553X. ; 37:2, s. 106-110
-
Tidskriftsartikel (refereegranskat)abstract
- Thymidine labelling indices (LI) and the number of clonal chromosome aberrations were assessed in fine‐needle aspirates from enlarged lymph nodes in 22 patients with non‐Hodgkin's lymphoma (NHL). 11 patients had LI > 3.0 (median 8.4) and 11 others had LI < 3.0 (median 1.0). Three categories of chromosome aberration were recorded: normal karyotype, 1–5 aberrations, and ≥ 6 aberrations or multiple complex changes. The distribution of these categories was different among the patients with LI > 3.0 compared to those with LI < 3.0 (p = 0.02). 8 of 11 patients with LI > 3.0 had ≥ 6 or complex changes. The corresponding figures for patients with LI < 3.0 were 2 out of 11. When 16 previously untreated patients were analysed separately, the median number of clonal aberrations was 6.5 in 8 patients with LI > 3.0 and 2.5 in 8 others with LI < 3.0 (p = 0.025). The results suggest that early and spontaneous changes in the genetic material are common in lymphomas with a high proliferative activity. According to previous studies, therapeutic results are especially poor in NHL with high LI. It is proposed that a high proliferative activity of lymphoma cells facilitates an early development of several new mutants and that some of these may be resistant to chemotherapeutic agents.
|
|
| 3. |
- Brandt, Lars, et al.
(författare)
-
Relation between occupational exposure to organic solvents and chromosome aberrations in non‐Hodgkin's lymphoma
- 1989
-
Ingår i: European Journal of Haematology. - : Wiley. - 0902-4441 .- 1600-0609. ; 42:3, s. 298-302
-
Tidskriftsartikel (refereegranskat)abstract
- Chromosome analysis of lymphoma cells was performed in 54 untreated patients with non‐Hodgkin's lymphoma (NHL). 10 patients had a history of daily occupational handling of organic solvents for at least 1 year (exposed group) and 44 patients had never (or only for shorter periods) worked with solvents (unexposed group). There were no differences between exposed and unexposed patients regarding age, clinical stage or histologic malignancy grade. The patients were assigned to three categories: Patients with 0–4, 5–9, or ≥ 10 cytogenetic events producing clonal aberrations of the lymphoma cells. The proportions of exposed patients in these categories were 2/26 (8%), 5/20 (25%) and 3/8 (38%); respectively, i.e. with increasing numbers of events there was an increasing probability of previous exposure to solvents (p = 0.035; trend analysis). 5 of 7 exposed patients (71%) with intermediate or high‐grade lymphomas displayed translocations involving the band 14q32. Such 14q+ markers were found in only 5 out of 28 unexposed patients (18%) with lymphomas of comparable malignancy grade (p = 0.01). Among unexposed patients with intermediate or high‐grade lymphoma the most common clonal aberration was 6q‐ which occurred in 10 out of 28 patients (36%). This abnormality was not observed in the exposed patients with lymphomas of corresponding malignancy grades (p = 0.08). It thus appears that the number of clonal chromosome aberrations is especially large in NHL patients with a history of occupational exposure to organic solvents. Moreover, such exposure may be associated with characteristic cytogenetic changes in the lymphoma cells.
|
|
| 4. |
- Brandt, Lars, et al.
(författare)
-
Survival following combination chemotherapy in advanced high grade non‐Hodgkin's lymphomas : Relation to proliferative activity of the lymphoma cells
- 1987
-
Ingår i: European Journal of Haematology. - : Wiley. - 0902-4441 .- 1600-0609. ; 38:5, s. 437-441
-
Tidskriftsartikel (refereegranskat)abstract
- In 18 untreated adult patients (median age 62.5 yr) with advanced non‐Hodgkin's lymphoma of unfavourable histology, thymidine labelling indices (LIs) of the lymphoma cells were assessed. The patients were treated with combination chemotherapy and have been followed for 29–60 (median 52) months or until death. The survival curve had a steep fall during the first 2 yr. Between 2–5 yr after treatment there was a flattening of the curve and survival seemed to be similar to the survival expected for a Swedish population matched for age and sex. 11 patients died with 2 yr and 7 patients have survived for a longer period. Age, histopathologic classification and clinical stages were comparable in short‐term and long‐term survivors and treatment was not more aggressive for the long‐term survivors. The LIs were significantly higher (median 8.2) in short‐term survivors than in the long‐term survivors (median 1.4). Long‐term survival following combination chemotherapy of advanced NHL of unfavourable histology seems to be achieved mainly in patients with a low proliferative activity of the lymphoma cells. It is suggested that in NHL a high proliferative activity may facilitate the generation of new mutants and that some of these are spontaneously resistant to various chemotherapeutic drugs.
|
|
| 5. |
|
|
