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Träfflista för sökning "WFRF:(Brantsing Camilla) ;pers:(Inerot Sven 1948)"

Sökning: WFRF:(Brantsing Camilla) > Inerot Sven 1948

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1.
  • Asp, Julia, 1973, et al. (författare)
  • Changes in p14(ARF) do not play a primary role in human chondrosarcoma tissues.
  • 2001
  • Ingår i: International journal of cancer. Journal international du cancer. - 0020-7136. ; 93:5, s. 703-5
  • Tidskriftsartikel (refereegranskat)abstract
    • The locus encoding the tumor suppressor p16 has been found to code for a second, different protein. This protein, p14(ARF), has been shown to protect p53 from degradation. Like p16, its gene is often altered in different cancers. In this study, the first unique exon, exon 1 beta, of p14(ARF), has been studied in 22 chondrosarcoma tissues using polymerase chain reaction, DNA sequencing and methylation-specific polymerase chain reaction. One chondrosarcoma was found to have exon 1 beta homozygously deleted, but neither mutations nor methylations were found in any of the chondrosarcomas. This indicates that genetic changes of p14(ARF) are a rare event in chondrosarcoma.
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2.
  • Asp, Julia, 1973, et al. (författare)
  • Evaluation of p16 and Id1 status and endogenous reference genes in human chondrosarcoma by real-time PCR.
  • 2005
  • Ingår i: International journal of oncology. - 1019-6439. ; 27:6, s. 1577-82
  • Tidskriftsartikel (refereegranskat)abstract
    • Both the tumour suppressor, p16, and the helix-loop-helix transcription factor, Id1, have been assigned roles in tumour growth in general and appear to be involved in chondrosarcoma. Id1 has further been found to repress the expression of p16. Therefore, the mRNA expression of these two genes was studied by real-time PCR in a search for prognostic markers in human chondrosarcoma. To get reliable quantitative data, however, the choice of endogenous reference gene for use in the assay is important. Therefore, eleven different endogenous reference genes were evaluated in chondrosarcoma cells and articular chondrocytes. 18S rRNA appeared to be the best choice to use as endogenous reference gene, since it was suitable for both kinds of cells. Several of the other reference genes tested showed variation between individuals or between normal chondrocytes and chondrosarcoma cells. This demonstrates the importance of using a correct endogenous reference gene to get reliable results from quantitative measurements. Both p16 and Id1 showed varied gene expression patterns among the samples and none of these genes could be significantly correlated to prognosis.
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