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  • Brodeur, SR, et al. (author)
  • C4b-binding protein (C4BP) activates B cells through the CD40 receptor
  • 2003
  • In: Immunity. - 1074-7613. ; 18:6, s. 837-848
  • Journal article (peer-reviewed)abstract
    • We demonstrate that the a. chain of human C4b binding protein (C4BP) binds directly to CD40 on human B cells at a site that differs from that used by CD40 ligand. C4BP induces proliferation, upregulation of CD54 and CD86 expression, and IL4-dependent IgE isotype switching in normal B cells but not in B cells from patients with CD40 or IKKgamma/NEMO deficiencies. Furthermore, C4BP colocalized with B cells in the germinal centers of human tonsils. These observations suggest that C4BP is an activating ligand for CD40 and establish a novel interface between complement and B cell activation.
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Notarangelo, LD (1)
Plebani, A (1)
Geha, RS (1)
Blom, Anna (1)
Dahlbäck, Björn (1)
Bacharier, LB (1)
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Brodeur, SR (1)
Angelini, F (1)
Mizoguchi, E (1)
Fujiwara, H (1)
Tsitsikov, E (1)
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University
Lund University (1)
Language
English (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Year
2003 (1)

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