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Sökning: WFRF:(Brodie Daniel) > Kungliga Tekniska Högskolan

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1.
  • Donker, Dirk W., et al. (författare)
  • Left ventricular unloading during veno-arterial ECMO : a review of percutaneous and surgical unloading interventions
  • 2019
  • Ingår i: Perfusion. - : Sage Publications. - 0267-6591 .- 1477-111X. ; 34:2, s. 98-105
  • Forskningsöversikt (refereegranskat)abstract
    • Short-term mechanical support by veno-arterial extracorporeal membrane oxygenation (VA ECMO) is more and more applied in patients with severe cardiogenic shock. A major shortcoming of VA ECMO is its variable, but inherent increase of left ventricular (LV) mechanical load, which may aggravate pulmonary edema and hamper cardiac recovery. In order to mitigate these negative sequelae of VA ECMO, different adjunct LV unloading interventions have gained a broad interest in recent years. Here, we review the whole spectrum of percutaneous and surgical techniques combined with VA ECMO reported to date.
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2.
  • Donker, Dirk W., et al. (författare)
  • Left Ventricular Unloading During Veno-Arterial ECMO : A Simulation Study
  • 2019
  • Ingår i: ASAIO journal (1992). - : Lippincott Williams and Wilkins. - 1058-2916 .- 1538-943X. ; 65:1, s. 11-20
  • Tidskriftsartikel (refereegranskat)abstract
    • Veno-arterial extracorporeal membrane oxygenation (VA ECMO) is widely used in cardiogenic shock. It provides systemic perfusion, but left ventricular (LV) unloading is suboptimal. Using a closed-loop, real-time computer model of the human cardiovascular system, cardiogenic shock supported by peripheral VA ECMO was simulated, and effects of various adjunct LV unloading interventions were quantified. After VA ECMO initiation (4 L/min) in cardiogenic shock (baseline), hemodynamics improved (increased to 85 mm Hg), while LV overload occurred (10% increase in end-diastolic volume [EDV], and 5 mm Hg increase in pulmonary capillary wedge pressure [PCWP]). Decreasing afterload (65 mm Hg mean arterial pressure) and circulating volume (-800 mL) reduced LV overload (12% decrease in EDV and 37% decrease in PCWP) compared with baseline. Additional intra-aortic balloon pumping only marginally decreased cardiac loading. Instead, adjunct Impella T enhanced LV unloading (23% decrease in EDV and 41% decrease in PCWP). Alternative interventions, for example, left atrial/ventricular venting, yielded substantial unloading. We conclude that real-time simulations may provide quantitative clinical measures of LV overload, depending on the degree of VA ECMO support and adjunct management. Simulations offer insights into individualized LV unloading interventions in cardiogenic shock supported by VA ECMO as a proof of concept for potential future applications in clinical decision support, which may help to improve individualized patient management in complex cardiovascular disease.
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  • Resultat 1-2 av 2
Typ av publikation
tidskriftsartikel (1)
forskningsöversikt (1)
Typ av innehåll
refereegranskat (2)
Författare/redaktör
Broomé, Michael (2)
Henriques, José P S (2)
Donker, Dirk W. (2)
Brodie, Daniel (2)
Lärosäte
Karolinska Institutet (2)
Språk
Engelska (2)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (2)
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