SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Broer Linda) ;pers:(Zillikens M. Carola)"

Sökning: WFRF:(Broer Linda) > Zillikens M. Carola

  • Resultat 1-4 av 4
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Justice, Anne E., et al. (författare)
  • Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution
  • 2019
  • Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 51:3, s. 452-469
  • Tidskriftsartikel (refereegranskat)abstract
    • Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted coding and splice site variants available on exome arrays in up to 344,369 individuals from five major ancestries (discovery) and 132,177 European-ancestry individuals (validation). We identified 15 common (minor allele frequency, MAF >= 5%) and nine low-frequency or rare (MAF < 5%) coding novel variants. Pathway/gene set enrichment analyses identified lipid particle, adiponectin, abnormal white adipose tissue physiology and bone development and morphology as important contributors to fat distribution, while cross-trait associations highlight cardiometabolic traits. In functional follow-up analyses, specifically in Drosophila RNAi-knockdowns, we observed a significant increase in the total body triglyceride levels for two genes (DNAH10 and PLXND1). We implicate novel genes in fat distribution, stressing the importance of interrogating low-frequency and protein-coding variants.
  •  
2.
  •  
3.
  • Stolk, Lisette, et al. (författare)
  • Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways
  • 2012
  • Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 44:3, s. 260-268
  • Tidskriftsartikel (refereegranskat)abstract
    • To newly identify loci for age at natural menopause, we carried out a meta-analysis of 22 genome-wide association studies (GWAS) in 38,968 women of European descent, with replication in up to 14,435 women. In addition to four known loci, we identified 13 loci newly associated with age at natural menopause (at P < 5 × 10(-8)). Candidate genes located at these newly associated loci include genes implicated in DNA repair (EXO1, HELQ, UIMC1, FAM175A, FANCI, TLK1, POLG and PRIM1) and immune function (IL11, NLRP11 and PRRC2A (also known as BAT2)). Gene-set enrichment pathway analyses using the full GWAS data set identified exoDNase, NF-κB signaling and mitochondrial dysfunction as biological processes related to timing of menopause.
  •  
4.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-4 av 4
Typ av publikation
tidskriftsartikel (4)
Typ av innehåll
refereegranskat (4)
Författare/redaktör
Rotter, Jerome I. (4)
Broer, Linda (4)
Zillikens, M. Ca... (4)Ta bort avgränsningen
Lind, Lars (3)
Rudan, Igor (3)
van Duijn, Cornelia ... (3)
visa fler...
Thorsteinsdottir, Un ... (3)
Stefansson, Kari (3)
Luan, Jian'an (3)
Rivadeneira, Fernand ... (3)
Uitterlinden, André ... (3)
Psaty, Bruce M (3)
Hayward, Caroline (3)
Polasek, Ozren (3)
Karlsson, Magnus (2)
Vandenput, Liesbeth, ... (2)
Lorentzon, Mattias, ... (2)
Salomaa, Veikko (2)
Perola, Markus (2)
Soranzo, Nicole (2)
Campbell, Harry (2)
Ohlsson, Claes, 1965 (2)
Wareham, Nicholas J. (2)
Kuusisto, Johanna (2)
Laakso, Markku (2)
Ridker, Paul M. (2)
Chasman, Daniel I. (2)
Ikram, M. Arfan (2)
Boehnke, Michael (2)
Tuomilehto, Jaakko (2)
Thorleifsson, Gudmar (2)
Melhus, Håkan (2)
Mellström, Dan, 1945 (2)
Oostra, Ben A. (2)
Gieger, Christian (2)
Wichmann, H. Erich (2)
Walker, Mark (2)
Spector, Timothy D (2)
Hsu, Yi-Hsiang (2)
Wilson, James F. (2)
Michaëlsson, Karl (2)
Eriksson, Johan G. (2)
Eiriksdottir, Gudny (2)
Harris, Tamara B (2)
Launer, Lenore J (2)
Loos, Ruth J F (2)
Hofman, Albert (2)
Völzke, Henry (2)
Gudnason, Vilmundur (2)
Boerwinkle, Eric (2)
visa färre...
Lärosäte
Göteborgs universitet (2)
Uppsala universitet (2)
Umeå universitet (1)
Lunds universitet (1)
Karolinska Institutet (1)
Språk
Engelska (4)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (3)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy