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Sökning: WFRF:(Browne Michael)

  • Resultat 1-10 av 82
  • [1]234567...9Nästa
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1.
  • Bustin, Stephen A., et al. (författare)
  • The need for transparency and good practices in the qPCR literature
  • 2013
  • Ingår i: Nature Methods. - 1548-7091 .- 1548-7105. ; 10:11, s. 1063-1067
  • Tidskriftsartikel (övrigt vetenskapligt)abstract
    • Two surveys of over 1,700 publications whose authors use quantitative real-time PCR (qPCR) reveal a lack of transparent and comprehensive reporting of essential technical information. Reporting standards are significantly improved in publications that cite the Minimum Information for Publication of Quantitative Real-Time PCR Experiments (MIQE) guidelines, although such publications are still vastly outnumbered by those that do not.
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  • Todoric, Jelena, et al. (författare)
  • Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas.
  • 2017
  • Ingår i: Cancer cell. - 1878-3686. ; 32:6, s. 824-839.e8
  • Tidskriftsartikel (refereegranskat)abstract
    • Despite expression of oncogenic KRAS, premalignant pancreatic intraepithelial neoplasia 1 (PanIN1) lesions rarely become fully malignant pancreatic ductal adenocarcinoma (PDAC). The molecular mechanisms through which established risk factors, such as chronic pancreatitis, acinar cell damage, and/or defective autophagy increase the likelihood of PDAC development are poorly understood. We show that accumulation of the autophagy substrate p62/SQSTM1 in stressed Kras(G12D) acinar cells is associated with PDAC development and maintenance of malignancy in human cells and mice. p62 accumulation promotes neoplastic progression by controlling the NRF2-mediated induction of MDM2, which acts through p53-dependent and -independent mechanisms to abrogate checkpoints that prevent conversion of differentiated acinar cells to proliferative ductal progenitors. MDM2 targeting may be useful for preventing PDAC development in high-risk individuals.
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  • Allen, J, et al. (författare)
  • Sustainability Strategies for City Logistics
  • 2012
  • Ingår i: McKinnon, A., Browne, M. and Whiteing, A. (eds.) Green Logistics: Improving the Environmental Sustainability of Logistics, Second Edition. - London : Kogan Page. - 978-0-7494-6625-1 ; s. 289-311
  • Bokkapitel (refereegranskat)
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9.
  • Allen, Julian, et al. (författare)
  • Sustainability Strategies for City Logistics
  • 2015
  • Ingår i: Green Logistics: Improving the Environmental Sustainability of Logistics, McKinnon, A., Browne, M., Whiteing, A. and Piecyk, M. (eds.) Third Edition. - London : Kogan Page. - 9780749471859
  • Bokkapitel (refereegranskat)
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10.
  • Allen, J, et al. (författare)
  • The role of urban consolidation centres in freight transport
  • 2012
  • Ingår i: Evangelista, P., McKinnon, A., Sweeney, E. and Esposito, E. (eds) Supply Chain Innovation for Competing in Highly Dynamic Markets: Challenges and Solutions. - Hershey PA : Business Science Reference. - 978-1-60960-585-8 ; s. 199-214
  • Bokkapitel (refereegranskat)
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  • Resultat 1-10 av 82
  • [1]234567...9Nästa
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