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| 2. |
- de Rojas, I., et al.
(författare)
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Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores
- 2021
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1
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Tidskriftsartikel (refereegranskat)abstract
- Genetic discoveries of Alzheimer’s disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer’s disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer’s disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer’s disease. © 2021, The Author(s).
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| 4. |
- Kattge, Jens, et al.
(författare)
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TRY plant trait database - enhanced coverage and open access
- 2020
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Ingår i: Global Change Biology. - : Wiley-Blackwell. - 1354-1013 .- 1365-2486. ; 26:1, s. 119-188
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Tidskriftsartikel (refereegranskat)abstract
- Plant traits-the morphological, anatomical, physiological, biochemical and phenological characteristics of plants-determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodiversity conservation, ecosystem and landscape management, restoration, biogeography and earth system modelling. Since its foundation in 2007, the TRY database of plant traits has grown continuously. It now provides unprecedented data coverage under an open access data policy and is the main plant trait database used by the research community worldwide. Increasingly, the TRY database also supports new frontiers of trait-based plant research, including the identification of data gaps and the subsequent mobilization or measurement of new data. To support this development, in this article we evaluate the extent of the trait data compiled in TRY and analyse emerging patterns of data coverage and representativeness. Best species coverage is achieved for categorical traits-almost complete coverage for 'plant growth form'. However, most traits relevant for ecology and vegetation modelling are characterized by continuous intraspecific variation and trait-environmental relationships. These traits have to be measured on individual plants in their respective environment. Despite unprecedented data coverage, we observe a humbling lack of completeness and representativeness of these continuous traits in many aspects. We, therefore, conclude that reducing data gaps and biases in the TRY database remains a key challenge and requires a coordinated approach to data mobilization and trait measurements. This can only be achieved in collaboration with other initiatives.
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- Bhowal, S., et al.
(författare)
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Development of collective structures over noncollective excitations in Nd-139
- 2011
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Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 84:2
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Tidskriftsartikel (refereegranskat)abstract
- High-spin states in Nd-139 were investigated using the reaction Zr-96(Ca-48,5n) at a beam energy of 195 MeV and gamma-ray coincidences were acquired with the Euroball spectrometer. Apart from several dipole bands at medium excitation energy, three quadrupole bands have been observed at high spin. Linking transitions connecting two of the high-spin bands to low-energy states have been observed. Calculations based on the cranked-Nilsson-Strutinsky formalism have been used to assign configurations for the high-spin quadrupole bands.
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| 6. |
- Leguillon, R., et al.
(författare)
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High-spin spectroscopy of Nd-140
- 2013
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Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 88:1
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Tidskriftsartikel (refereegranskat)abstract
- The population of the high-spin states in Nd-140 was investigated using the reaction Zr-96(Ca-48,4n). The results from two experiments, one with the EUROBALL array and one with the JUROGAM II + RITU + GREAT setup employing the recoil decay tagging technique, have been combined to develop a very detailed level scheme for Nd-140. Twelve bands of quadrupole transitions and eleven bands of dipole transitions were identified and their connections to low-lying states were established. Calculations using the cranked Nilsson-Strutinsky and the tilted axis cranking models were used to interpret the observed structures. The overall good agreement between the experimental results and the calculations assuming a triaxial shape of the nucleus strongly support the existence of a stable triaxial shape at high spins in this mass region.
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| 7. |
- Petrache, C. M., et al.
(författare)
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Triaxiality at high spins in Nd nuclei
- 2006
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Ingår i: Physica Scripta. - 0031-8949. ; T125, s. 212-213
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Tidskriftsartikel (refereegranskat)abstract
- The level structure of Nd-140(80) has been established up to spin 48 by in-beam gamma-ray spectroscopy using the Zr-96(Ca-48, 4n) reaction. High-fold gamma-ray coincidences were measured with the EUROBALL spectrometer. Twelve new rotational bands have been discovered at high spins, showing the change from a spherical single-particle behaviour at low spins to a deformed regime with stable triaxiality at high spins. Possible configurations are assigned to the observed bands on the basis of configuration-dependent cranked Nilsson-Strutinsky calculations.
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| 8. |
- Zerrouki, T., et al.
(författare)
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Shape evolution and magnetic rotation in Nd-141
- 2015
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Ingår i: European Physical Journal A. Hadrons and Nuclei. - : Springer Science and Business Media LLC. - 1434-6001. ; 51:4
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Tidskriftsartikel (refereegranskat)abstract
- The high-spin states in Nd-141 were investigated using the Zr-96(Ca-48, 3n) reaction and the EU-ROBALL array. The level scheme has been extended up to an excitation energy of around 16MeV and spin 81/2. Two new bands of dipole transitions and three bands presumably of quadrupole transitions were identified and their connections to low-lying states were established. Cranked Nilsson-Strutinsky and tilted axis cranking calculations are combined in the interpretation of the observed dipole bands. The high-spin bands with assigned quadrupole transitions are interpreted as triaxial bands, while the dipole bands appear in the calculations to exhibit a shape evolution from low-deformation triaxial to spherical shape. They can be classified as magnetic rotation, with transition probabilities that show the characteristic decrease with angular momentum caused by the shears mechanism.
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| 9. |
- Gorska, M., et al.
(författare)
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Nuclear Structure far off Stability - RISING Campaigns
- 2007
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Ingår i: Acta Physica Polonica. Series B: Elementary Particle Physics, Nuclear Physics, Statistical Physics, Theory of Relativity, Field Theory. - 0587-4254. ; 38:4, s. 1219-1228
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Tidskriftsartikel (refereegranskat)abstract
- Nuclear structure studies at CST attracted recently increased interest for the results of present activities as well as for the future project FAIR. A broad range of physics phenomena can be addressed by high-resolution in-beam gamma-ray spectroscopy experiments with radioactive beams offered within the Rare Isotopes Spectroscopic INvestigation at GSI (RISING) project. It combined the EUROBALL Ge-Cluster detectors, the MINIBALL Ce detectors, the HECTOR-BaF detectors, and the fragment separator FRS. The secondary beams produced at relativistic energies were used for Coulomb excitation or secondary fragmentation experiments to study projectile like nuclei by measuring de-excitation photons. The first results of the "fast beam campaign" is discussed in comparison to various shell model calculations. The discussion focuses on the N = 32, 34 sub-shell closure based on neutron rich Cr isotopes. Alternatively, the relativistic radioactive beams, both in their ground and isomeric states, were implanted and their decay could be investigated. The "stopped beam campaign" has started in October 2005 with a series of g-factor measurements. It continued from February 2006 with the next, configuration and the main goal of identification of new isomers and angular momentum population in fragmentation reactions.
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| 10. |
- Nag, Somnath, et al.
(författare)
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Collective and noncollective states in (120)Te
- 2012
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Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 85:1
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Tidskriftsartikel (refereegranskat)abstract
- High-spin states in (120)Te were populated in the reaction (80)Se((48)Ca, alpha 4n)(120)Te at a beam energy of 207 MeV and gamma-ray coincidences were measured using the Gammasphere spectrometer. The previously known level scheme is extended to higher spin and new interband transitions and side-feeding branches are established. Five highly deformed rotational bands, extending up to almost I = 50, are observed for the first time. The bands are compared with similar structures found recently in neighboring nuclei. The experimental results are interpreted within the framework of the cranked Nilsson-Strutinsky model. Configuration assignments to several terminating states and to the high-spin bands are discussed.
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