| 1. |
- Kehoe, Laura, et al.
(författare)
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Make EU trade with Brazil sustainable
- 2019
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341-
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 2. |
- Wiedorn, Max O., et al.
(författare)
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Megahertz serial crystallography
- 2018
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Ingår i: Nature Communications. - : Nature Publishing Group. - 2041-1723. ; 9
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Tidskriftsartikel (refereegranskat)abstract
- The new European X-ray Free-Electron Laser is the first X-ray free-electron laser capable of delivering X-ray pulses with a megahertz inter-pulse spacing, more than four orders of magnitude higher than previously possible. However, to date, it has been unclear whether it would indeed be possible to measure high-quality diffraction data at megahertz pulse repetition rates. Here, we show that high-quality structures can indeed be obtained using currently available operating conditions at the European XFEL. We present two complete data sets, one from the well-known model system lysozyme and the other from a so far unknown complex of a beta-lactamase from K. pneumoniae involved in antibiotic resistance. This result opens up megahertz serial femtosecond crystallography (SFX) as a tool for reliable structure determination, substrate screening and the efficient measurement of the evolution and dynamics of molecular structures using megahertz repetition rate pulses available at this new class of X-ray laser source.
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| 3. |
- Sällvin, Lisa, et al.
(författare)
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On Design of Inclusive and Enjoyable Educational Games : The Gaming4Coding Concept
- 2024
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Ingår i: INTED2024 Proceedings. - Valencia, Spain : The International Academy of Technology, Education and Development. - 9788409592159
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Konferensbidrag (refereegranskat)abstract
- There is a long tradition of educational games and game-based learning, starting with the use of classic board games like Kalaha, Xiangxi, and Chess to train systematic and combinatoric thinking. These are highly relevant skills for the development of 21st century skills today, such as computational thinking and computer programming. To introduce computer programming for secondary school students is a prioritised initiative in many countries, and the idea is to achieve programming for all. At the same time as, educational games are a mainstream activity in many educational contexts and research studies have reported that many games do not attract a female audience. The same lack of female interest can be found in studies on the gender unbalance in STEM education. This study has the aim of looking at design concepts for girl inclusive design in educational games on computer science. Several of these concepts have been applied to a game called Code Quest, a game where players collect fantasy creatures called 'critters' which can be trained by giving them instruction scripts. The critter training is by purpose not called programming in order to give the game less of a technical feeling and more the feeling of fantasy and fun. The evaluation of Code Quest highlights several important features in the design of an inclusive game on computer science, but also several challenges that need further investigation. This study was carried out as a part of a larger design science project, with a focus on demonstration and evaluation of the game artefact. Findings from the first iteration of testing show promising results for the girl inclusive design ideas. On the other hand, there are still several traditional design issues and bugs left to address. Finally, as in all game development there is a need for several test iterations before the game will be a useful complement to programming education in secondary school.
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| 4. |
- Yefanov, Oleksandr, et al.
(författare)
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Evaluation of serial crystallographic structure determination within megahertz pulse trains
- 2019
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Ingår i: Structural Dynamics. - : AMER INST PHYSICS. - 2329-7778. ; 6:6
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Tidskriftsartikel (refereegranskat)abstract
- The new European X-ray Free-Electron Laser (European XFEL) is the first X-ray free-electron laser capable of delivering intense X-ray pulses with a megahertz interpulse spacing in a wavelength range suitable for atomic resolution structure determination. An outstanding but crucial question is whether the use of a pulse repetition rate nearly four orders of magnitude higher than previously possible results in unwanted structural changes due to either radiation damage or systematic effects on data quality. Here, separate structures from the first and subsequent pulses in the European XFEL pulse train were determined, showing that there is essentially no difference between structures determined from different pulses under currently available operating conditions at the European XFEL.
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