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Sökning: WFRF:(Camenzind E)

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2.
  • Camenzind, E, et al. (författare)
  • Modifying effect of dual antiplatelet therapy on incidence of stent thrombosis according to implanted drug-eluting stent type
  • 2014
  • Ingår i: European Heart Journal. - : Oxford University Press (OUP). - 0195-668X .- 1522-9645. ; 35:29, s. 1932-1948
  • Tidskriftsartikel (refereegranskat)abstract
    • AIM: To investigate the putative modifying effect of dual antiplatelet therapy (DAPT) use on the incidence of stent thrombosis at 3 years in patients randomized to Endeavor zotarolimus-eluting stent (E-ZES) or Cypher sirolimus-eluting stent (C-SES). METHODS AND RESULTS: Of 8709 patients in PROTECT, 4357 were randomized to E-ZES and 4352 to C-SES. Aspirin was to be given indefinitely, and clopidogrel/ticlopidine for >/= 3 months or up to 12 months after implantation. Main outcome measures were definite or probable stent thrombosis at 3 years. Multivariable Cox regression analysis was applied, with stent type, DAPT, and their interaction as the main outcome determinants. Dual antiplatelet therapy adherence remained the same in the E-ZES and C-SES groups (79.6% at 1 year, 32.8% at 2 years, and 21.6% at 3 years). We observed a statistically significant (P = 0.0052) heterogeneity in treatment effect of stent type in relation to DAPT. In the absence of DAPT, stent thrombosis was lower with E-ZES vs. C-SES (adjusted hazard ratio 0.38, 95% confidence interval 0.19, 0.75; P = 0.0056). In the presence of DAPT, no difference was found (1.18; 0.79, 1.77; P = 0.43). CONCLUSION: A strong interaction was observed between drug-eluting stent type and DAPT use, most likely prompted by the vascular healing response induced by the implanted DES system. These results suggest that the incidence of stent thrombosis in DES trials should not be evaluated independently of DAPT use, and the optimal duration of DAPT will likely depend upon stent type (Clinicaltrials.gov number NCT00476957).
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3.
  • Camenzind, Adrian, et al. (författare)
  • Nanostructure evolution : From aggregated to spherical SiO2 particles made in diffusion flames
  • 2008
  • Ingår i: European Journal of Inorganic Chemistry. - : Wiley. - 1434-1948 .- 1099-1948 .- 1099-0682. ; :6, s. 911-918
  • Tidskriftsartikel (refereegranskat)abstract
    • The formation of nanostructured silica particles by oxidation of hexamethyldisiloxane (HMDSO) in co-annular diffusion flames is investigated by in-situ small-angle X-ray scattering (SAXS). This enabled the nonintrusive monitoring of the mass fractal dimension, the aggregate size, and the number of primary particles per aggregate, along with the silica volume fraction, the primary particle diameter, the geometric standard deviation, and the number density along the flame axis. Parallel to this, thermophoretic sampling (TS) of the particles and analysis by transmission electron microscopy (TEM) allowed for direct comparison of particle morphology to that obtained from the above SAXS analysis, which were compared also to the ultra-small-angle X-ray scattering (US-AXS) data for product particles collected from the filter. The flame temperature was measured by in-situ Fourier transform infrared (FTIR) spectroscopy. By increasing the oxygen flow rate, the laminar diffusion flame changed to a turbulent, premixed-like flame. Non-aggregated, spherical particles were formed in the former, while aggregates were formed in the latter flame. The relatively long high-temperature particle residence times in the laminar diffusion flame facilitated sintering of the aggregates formed earlier into compact spherical particles at later stages of the flame. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008).
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4.
  • Sotiriou, Georgios A., et al. (författare)
  • Nanosilver on nanostructured silica : Antibacterial activity and Ag surface area
  • 2011
  • Ingår i: Chemical Engineering Journal. - : Elsevier BV. - 1385-8947 .- 1873-3212. ; 170:2-3, s. 547-554
  • Tidskriftsartikel (refereegranskat)abstract
    • Nanosilver is one of the first nanomaterials to be closely monitored by regulatory agencies worldwide motivating research to better understand the relationship between Ag characteristics and antibacterial activity. Nanosilver immobilized on nanostructured silica facilitates such investigations as the SiO2 support hinders the growth of nanosilver during its synthesis and, most importantly, its flocculation in bacterial suspensions. Here, such composite Ag/silica nanoparticles were made by flame spray pyrolysis of appropriate solutions of Ag-acetate or Ag-nitrate and hexamethyldisiloxane or tetraethylorthosilicate in ethanol, propanol, diethylene glucolmonobutyl ether, acetonitrile or ethylhexanoic acid. The effect of solution composition on nanosilver characteristics and antibacterial activity against the Gram negative Escherichia coli was investigated by monitoring their recombinantly synthesized green fluorescent protein. Suspensions with identical Ag mass concentration exhibited drastically different antibacterial activity pointing out that the nanosilver surface area concentration rather than its mass or molar or number concentration determine best its antibacterial activity. Nanosilver made from Ag-acetate showed a unimodal size distribution, while that made from inexpensive Ag-nitrate exhibited a bimodal one. Regardless of precursor composition or nanosilver size distribution, the antibacterial activity of nanosilver was correlated best with its surface area concentration in solution. (C) 2011 Elsevier B.V. All rights reserved.
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