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Early Prediction of...
Early Prediction of Delayed Ischemia and Functional Outcome in Acute Subarachnoid Hemorrhage : Role of Diffusion Tensor Imaging
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- Fragata, Isabel (författare)
- Ctr Hosp Lisboa Cent, Dept Neuroradiol, Rua Jose Antonio Serrano, P-1150099 Lisbon, Portugal.
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- Alves, Marta (författare)
- Ctr Hosp Lisboa Cent, Ctr Invest, Lisbon, Portugal.
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- Papoila, Ana Lusia (författare)
- Ctr Hosp Lisboa Cent, Ctr Invest, Lisbon, Portugal.;Ctr Hosp Lisboa Cent, Unidade Cerebrovasc, Lisbon, Portugal.;NOVA Med Sch, Fac Ciencias Med, Lisbon, Portugal.
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Nunes, Ana Paiva (författare)
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- Ferreira, Patricia (författare)
- Ctr Hosp Lisboa Cent, Unidade Cerebrovasc, Lisbon, Portugal.
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- Canto-Moreira, Nuno (författare)
- Uppsala universitet,Radiologi
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- Canhao, Patricia (författare)
- Ctr Hosp Lisboa Norte, Dept Neurol, Lisbon, Portugal.;Univ Lisbon, Fac Med, Inst Med Mol, Lisbon, Portugal.
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Ctr Hosp Lisboa Cent, Dept Neuroradiol, Rua Jose Antonio Serrano, P-1150099 Lisbon, Portugal Ctr Hosp Lisboa Cent, Ctr Invest, Lisbon, Portugal. (creator_code:org_t)
- 2017
- 2017
- Engelska.
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Ingår i: Stroke. - 0039-2499 .- 1524-4628. ; 48:8, s. 2091-2097
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background and Purpose-Diffusion tensor imaging (DTI) parameters are markers of cerebral lesion in some diseases. In patients with acute subarachnoid hemorrhage (SAH), we investigated whether DTI parameters measured at < 72 hours might be associated with delayed cerebral ischemia (DCI) and with poor functional outcome at 3 months (modified Rankin Scale score =3).Methods-DTI was performed in a prospective cohort of 60 patients with nontraumatic SAH at < 72 hours. Association of fractional anisotropy and apparent diffusion coefficient values at < 72 hours with the occurrence of DCI and outcome at 3 months was evaluated with logistic regression models, adjusting for known predictors of prognosis.Results-At < 72 hours after SAH, fractional anisotropy values at the cerebellum were associated with DCI occurrence (78% less odds of DCI for each 0.1 increase in fractional anisotropy; P=0.019). Early apparent diffusion coefficient values were not associated with DCI. After adjusting for confounding variables, an increase of 10 U in apparent diffusion coefficient at the frontal centrum semiovale corresponded to 15% increased odds of poor outcome (P=0.061).Conclusions-DTI parameters at < 72 hours post-SAH are independently associated with the occurrence of DCI and functional outcome. These preliminary results suggest the role of DTI parameters as surrogate markers of prognosis in nontraumatic SAH.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- anisotropy
- cerebral ischemia
- diffusion tensor imaging
- prognosis
- subarachnoid hemorrhage
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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