| 1. |
- Carlsen, Henrik, et al.
(författare)
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Co-evolutionary scenarios for creative prototyping of future robot systems for civil protection
- 2014
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Ingår i: Technological forecasting & social change. - : Elsevier BV. - 0040-1625 .- 1873-5509. ; 84, s. 93-100
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Tidskriftsartikel (refereegranskat)abstract
- Co-evolutionary scenarios are used for creative prototyping with the purpose of assessing potential implications of future autonomous robot systems on civil protection. The methodology is based on a co-evolutionary scenario approach and the development of different evolutionary paths. Opportunities, threats and ethical aspects in connection with the introduction of robotics in the domestic security and safety sector are identified using an iterative participatory workshop methodology. Three creative prototypes of robotic systems are described: "RoboMall", "RoboButler" and "SnakeSquad". The debate in society that might follow the introduction of these three robot systems and society's response to the experienced ethical problems and opportunities are discussed in the context of two scenarios of different future societies.
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| 2. |
- Carlsen, Henrik, et al.
(författare)
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Systematic exploration of scenario spaces
- 2016
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Ingår i: Foresight. - 1463-6689 .- 1465-9832. ; 18:1, s. 59-75
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Tidskriftsartikel (refereegranskat)abstract
- Purpose - Scenarios have become a vital methodological approach in business as well as in public policy. When scenarios are used to guide analysis and decision-making, the aim is typically robustness and in this context we argue that two main problems at scenario set level is conservatism, i.e. all scenarios are close to a perceived business-as-usual trajectory and lack of balance in the sense of arbitrarily mixing some conservative and some extreme scenarios. The purpose of this paper is to address these shortcomings by proposing a methodology for generating sets of scenarios which are in a mathematical sense maximally diverse. Design/methodology/approach - In this paper, we develop a systematic methodology, Scenario Diversity Analysis (SDA), which addresses the problems of broad span vs conservatism and imbalance. From a given set of variables with associated states, SDA generates scenario sets where the scenarios are in a quantifiable sense maximally different and therefore best span the whole set of feasible scenarios. Findings - The usefulness of the methodology is exemplified by applying it to sets of storylines of the emissions scenarios of the Intergovernmental Panel on Climate Change. This ex-post analysis shows that the storylines were not maximally diverse and given the challenges ahead with regard to emissions reduction and adaptation planning, we argue that it is important to strive for diversity when developing scenario sets for climate change research. Originality/value - The proposed methodology adds significant novel features to the field of systematic scenario generation, especially with regard to scenario diversity. The methodology also enables the combination of systematics with the distinct future logics of good intuitive logics scenarios.
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| 3. |
- Gregers, Jannie, et al.
(författare)
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Polymorphisms in the ABCB1 gene affect outcome and toxicity in Childhood Acute Lymphoblastic Leukemia
- 2012
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- The membrane transporter P-glycoprotein, encoded by the ABCB1 gene, influences pharmacokinetics in several anti-cancer drugs. We hypothesized that 1199G>A, 1236C>T, 2677G>A/T and 3435C>T variants of ABCB1 could affect outcome and toxicity in childhood acute lymphoblastic leukemia (ALL), since treatment includes known P-glycoprotein substrates and 3435C/T may affect methotrexate therapy. We studied 522 Danish children with ALL treated according to NOPHO ALL92 and ALL2000 protocols, 93% of all those eligible during 1992-2007. Risk of relapse was 2.9-fold increased for 41 patients with the 1199GA variant compared to 477 with 1199GG (p=0.001), and reduced by 61% and 40%, respectively for 421 patients with the 3435CT or 3435TT variants compared to 96 with 3435CC (overall p=0.02). Degree of bone marrow toxicity during doxorubicin, vincristine and prednisolone induction therapy was higher in 71 patients with 3435TT variant (median nadirs: hemoglobin 3% and platelets 34/37% lower in3435CT/3435CC) compared to 160 patients with 3435CT/3435CC (Hemoglobin p=0.01 and platelets p<0.0001). We observed more liver toxicity after high-dose methotrexate in 109 patients with 3435CC variant versus 3435CT/TT (Median max alanineaminotransferase: 280 versus 142/111 U/L, p=0.03). In conclusion, there is a statistically significant association between ABCB1 polymorphisms and efficacy and toxicity in childhood ALL.
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| 4. |
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| 5. |
- Abrahamson, Magnus, et al.
(författare)
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Efficient production of native, biologically active human cystatin C by Escherichia coli
- 1988
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Ingår i: FEBS Letters. - 1873-3468. ; 236:1, s. 14-18
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Tidskriftsartikel (refereegranskat)abstract
- A cDNA encoding the mature human cysteine proteinase inhibitor cystatin C was fused to the coding sequence for the Escherichia coli outer membrane protein A signal peptide, and the recombinant gene was expressed in E. coli under the control of the λ PR promoter, an optimized Shine-Dalgarno sequence and the λ cI 857 repressor. When induced at 42°C, such cells expressed large amounts of recombinant cystatin C. The recombinant protein was isolated in high yield and characterized. All physicochemical properties investigated, including the positions of disulfide bonds, indicated that the E. coli derived cystatin C was identical to cystatin C isolated from human biological fluids, except that the proline residue in position three was not hydroxylated. The recombinant protein displayed full biological activity against papain, cathepsin B and dipeptidyl peptidase I.
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| 7. |
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| 8. |
- Baard, Patrik, et al.
(författare)
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Scenarios and sustainability : tools for alleviating the gap between municipal means and responsibilities in adaptation planning
- 2012
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Ingår i: Local Environment. - : Informa UK Limited. - 1354-9839 .- 1469-6711. ; 17:6-7, s. 641-662
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Tidskriftsartikel (refereegranskat)abstract
- Adaptation to climate change often involves long-time frames and uncertainties over the consequences of chosen adaptation measures. In this study, two tools designed for assisting local decision-makers in adaptation planning were tested: socio-economic scenarios and sustainability analysis. The objective was to study whether these tools could be of practical relevance to Swedish municipalities and facilitate local-level climate change adaptation. We found that the municipal planners who participated in the testing generally considered the tools useful and of high relevance, but that more time was needed to use the tools than was provided during the test process.
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| 9. |
- Bennich, Therese, 1989-, et al.
(författare)
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Deciphering the scientific literature on SDG interactions : A review and reading guide
- 2020
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Ingår i: Science of the Total Environment. - : Elsevier BV. - 0048-9697 .- 1879-1026. ; 728
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Forskningsöversikt (refereegranskat)abstract
- The 2030 Agenda includes 17 overarching Sustainable Development Goals (SDGs). These are integrated in nature, and a principle of indivisibility should guide their implementation. Yet, the 2030 Agenda itself does not provide guidance on what indivisibility means in practice, how the SDGs interact, or on how to assess these interactions. The fast-emerging field of what could be referred to as SDG interaction studies seeks to provide such guidance, but as of yet there is no general agreement on what it means to take an integrated approach to the SDGs. Hence, navigating the diverse research landscape on SDG interactions might prove challenging. This paper aims to decipher the literature on SDG interactions by providing an overview of the current research, based on a sample of 70 peer-reviewed articles. The review explores four themes in SDG interaction research by mapping: (i) policy challenges typically addressed, (ii) ways in which SDG ‘interactions’ have been conceptualized, (iii) data sources used, and (iv) methods of analysis frequently employed. Research gaps are identified, where perspectives largely missing include policy innovation, and integrated monitoring and evaluation. Further, few studies consider actor interactions, account for geographic spill-overs, analyze SDG indicator interactions, employ participatory methods, or take a whole-systems approach to the 2030 Agenda. Failing to address these gaps could lead to inefficient SDG implementation and delay goal attainment. Another contribution of the paper is a reading guide, proposing a way to decipher the literature along the themes emerging from the review, and offering a structure to code future papers.
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| 10. |
- Björklund, Verna, et al.
(författare)
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Early-onset group B streptococcal infections in five Nordic countries with different prevention policies, 1995 to 2019
- 2024
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Ingår i: Eurosurveillance. - : European Centre for Disease Control and Prevention (ECDC). - 1025-496X .- 1560-7917. ; 29:3
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Tidskriftsartikel (refereegranskat)abstract
- Background: Neonatal early-onset disease caused by group B Streptococcus (GBS) is a leading cause of infant morbidity. Intrapartum antibiotic prophylaxis (IAP) is effective in preventing early-onset GBS disease, but there is no agreement on the optimal strategy for identifying the pregnant women requiring this treatment, and both risk-based prophylaxis (RBP) and GBS screening-based prophylaxis (SBP) are used.Aim: The aim of this study was to evaluate the effect of SBP as a public health intervention on the epidemiology of early-onset GBS infections.Methods: In 2012, Finland started the universal SBP, while Denmark, Iceland, Norway and Sweden continued with RBP. We conducted an interrupted time series analysis taking 2012 as the intervention point to evaluate the impact of this intervention. The incidences of early- and late-onset GBS infections during Period I (1995-2011) and Period II (2012-2019) were collected from each national register, covering 6,605,564 live births.Results: In Finland, a reduction of 58% in the incidence of early-onset GBS disease, corresponding to an incidence rate ratio (IRR) of 0.42 (95% CI: 0.34-0.52), was observed after 2012. At the same time, the pooled IRR of other Nordic countries was 0.89 (95% CI: 0.80-1.0), specifically 0.89 (95% CI: 0.70-1.5) in Denmark, 0.34 (95% CI: 0.15-0.81) in Iceland, 0.72 (95% CI: 0.59-0.88) in Norway and 0.97 (95% CI: 0.85-1.1) in Sweden.Conclusions: In this ecological study of five Nordic countries, early-onset GBS infections were approximately halved following introduction of the SBP approach as compared with RBP.
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