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Träfflista för sökning "WFRF:(Carlsson A.) ;pers:(Carlsson Per)"

Sökning: WFRF:(Carlsson A.) > Carlsson Per

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  • Löfvenborg, J E, et al. (författare)
  • Fatty fish consumption and risk of latent autoimmune diabetes in adults
  • 2014
  • Ingår i: Nutrition & Diabetes. - : Springer Science and Business Media LLC. - 2044-4052. ; 4, s. e139-
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVE: It has been suggested that intake of fatty fish may protect against both type 1 and type 2 diabetes. Hypotheses rest on the high marine omega-3 fatty acid eicosapentaenoic acid+docosahexaenoic acid (EPA+DHA) and vitamin D contents, with possible beneficial effects on immune function and glucose metabolism. Our aim was to investigate, for the first time, fatty fish consumption in relation to the risk of latent autoimmune diabetes in adults (LADA).METHODS: Analyses were based on data from a Swedish case-control study with incident cases of LADA (n=89) and type 2 diabetes (n=462) and randomly selected diabetes-free controls (n=1007). Diabetes classification was based on the onset of age (⩾35), glutamic acid decarboxylase autoantibodies, and C-peptide. A validated food frequency questionnaire was used to derive information on previous intake of fish, polyunsaturated long-chain omega-3 fatty acids (n-3 PUFA) and supplementation of fish oil and vitamin D. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using logistic regression, adjusted for age, gender, body mass index (BMI), family history of diabetes, physical activity, smoking, education, and consumption of alcohol, fruit, vegetables and red meat.RESULTS: Weekly fatty fish consumption (⩾1 vs <1 serving per week), was associated with a reduced risk of LADA but not type 2 diabetes (OR 0.51, 95% CI 0.30-0.87, and 1.01, 95% CI 0.74-1.39, respectively). Similar associations were seen for estimated intake of n-3 PUFA (⩾0.3 g per day; LADA: OR 0.60, 95% CI 0.35-1.03, type 2 diabetes: OR 1.14, 95% CI 0.79-1.58) and fish oil supplementation (LADA: OR 0.47, 95% CI 0.19-1.12, type 2 diabetes: OR 1.58, 95% CI 1.08-2.31).CONCLUSIONS: Our findings suggest that fatty fish consumption may reduce the risk of LADA, possibly through effects of marine-originated omega-3 fatty acids.
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  • Rasouli, B., et al. (författare)
  • Coffee consumption, genetic susceptibility and risk of latent autoimmune diabetes in adults : A population-based case-control study
  • 2018
  • Ingår i: Diabetes & Metabolism. - : Elsevier BV. - 1262-3636 .- 1878-1780. ; 44:4, s. 354-360
  • Tidskriftsartikel (refereegranskat)abstract
    • Aim: Coffee consumption is inversely related to risk of type 2 diabetes (T2D). In contrast, an increased risk of latent autoimmune diabetes in adults (LADA) has been reported in heavy coffee consumers, primarily in a subgroup with stronger autoimmune characteristics. Our study aimed to investigate whether coffee consumption interacts with HLA genotypes in relation to risk of LADA. Methods: This population-based study comprised incident cases of LADA (n = 484) and T2D (n = 1609), and also 885 healthy controls. Information on coffee consumption was collected by food frequency questionnaire. Odds ratios (ORs) with 95% CIs of diabetes were calculated and adjusted for age, gender, BMI, education level, smoking and alcohol intake. Potential interactions between coffee consumption and high-risk HLA genotypes were calculated by attributable proportion (AP) due to interaction. Results: Coffee intake was positively associated with LADA in carriers of high-risk HLA genotypes (OR: 1.14 per cup/day, 95% CI: 1.02–1.28), whereas no association was observed in non-carriers (OR: 1.04, 95% CI: 0.93–1.17). Subjects with both heavy coffee consumption (≥ 4 cups/day) and high-risk HLA genotypes had an OR of 5.74 (95% CI: 3.34–9.88) with an estimated AP of 0.36 (95% CI: 0.01–0.71; P = 0.04370). Conclusion: Our findings suggest that coffee consumption interacts with HLA to promote LADA.
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  • Andersson, A, et al. (författare)
  • Resource allocation with wobbly functions
  • 2002
  • Ingår i: Computational Optimization and Applications. - 0926-6003. ; 23:2, s. 171-200
  • Tidskriftsartikel (refereegranskat)abstract
    • We consider resource allocation with separable objective functions defined over subranges of the integers. While it is well known that (the maximisation version of) this problem can be solved efficiently if the objective functions are concave, the general problem of resource allocation with functions that are not necessarily concave is difficult. In this article, we focus on a large class of problem instances, with objective functions that are close to a concave function or some other smooth function, but with small irregularities in their shape. It is described that these properties are important in many practical situations. The irregularities make it hard or impossible to use known, efficient resource allocation techniques. We show that, for this class of functions the optimal solution can be computed efficiently. We support our claims by experimental evidence. Our experiments show that our algorithm in hard and practically relevant cases runs up to 40-60 times faster than the standard method.
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  • Becker, Elin, 1981, et al. (författare)
  • In Situ Spectroscopic Investigation of Low-Temperature Oxidation of Methane over Alumina-Supported Platinum during Periodic Operation
  • 2011
  • Ingår i: Journal of Physical Chemistry C. - : American Chemical Society (ACS). - 1932-7447 .- 1932-7455. ; 115:4, s. 944-951
  • Tidskriftsartikel (refereegranskat)abstract
    • Methane oxidation over Pt/Al2O3 at transient inlet-gas conditions was studied in situ using synchronous energy dispersive X-ray absorption spectroscopy, Fourier transform infrared spectroscopy, and mass spectrometry. The employed combination of experimental techniques allows for simultaneous analysis of the electronic state of platinum, surface coverage of reaction intermediates/products, and catalytic activity/selectivity, respectively. By cycling of the feed gas composition between net-oxidizing and net-reducing conditions, the activity for methane oxidation can be increased as compared to continuous net-oxidizing conditions. Using the white-line area of time-resolved X-ray absorption near-edge structure spectra, a quantitative estimation of the surface O/Pt ratio indicates the formation of an inhomogeneous surface oxide on the platinum crystallites during reaction. The obtained temporary high activity can be explained through Langmuir-Hinshelwood kinetics and may result either from the formation of a partially oxidized platinum surface that is more effective for methane dissociation or, more likely, from a period with more reactive chemisorbed oxygen prior to oxide formation.
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  • Bruno, A., et al. (författare)
  • The May 17, 2012 solar event : back-tracing analysis and flux reconstruction with PAMELA
  • 2016
  • Ingår i: INTERNATIONAL CONFERENCE ON PARTICLE PHYSICS AND ASTROPHYSICS (ICPPA-2015), PTS 1-4. - : Institute of Physics (IOP).
  • Konferensbidrag (refereegranskat)abstract
    • The PAMELA space experiment is providing first direct observations of Solar Energetic Particles (SEPs) with energies from about 80 MeV to several GeV in near-Earth orbit, bridging the low energy measurements by other spacecrafts and the Ground Level Enhancement (GLE) data by the worldwide network of neutron monitors. Its unique observational capabilities include the possibility of measuring the flux angular distribution and thus investigating possible anisotropies associated to SEP events. The analysis is supported by an accurate back-tracing simulation based on a realistic description of the Earth's magnetosphere, which is exploited to estimate the SEP energy spectra as a function of the asymptotic direction of arrival with respect to the Interplanetary Magnetic Field (IMF). In this work we report the results for the May 17, 2012 event.
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