Sökning: WFRF:(Casar Borota Olivera)
> Jorgensen Anders P. >
FSH Levels Are Rela...
FSH Levels Are Related to E-cadherin Expression and Subcellular Location in Nonfunctioning Pituitary Tumors
-
- Kolnes, Anders J. (författare)
- Oslo Univ Hosp, Dept Endocrinol, Sect Specialized Endocrinol, Oslo, Norway.;Univ Oslo, Fac Med, Oslo, Norway.
-
- Oystese, Kristin A. B. (författare)
- Oslo Univ Hosp, Dept Endocrinol, Sect Specialized Endocrinol, Oslo, Norway.;Univ Oslo, Fac Med, Oslo, Norway.
-
- Olarescu, Nicoleta C. (författare)
- Oslo Univ Hosp, Dept Endocrinol, Sect Specialized Endocrinol, Oslo, Norway.;Univ Oslo, Fac Med, Oslo, Norway.
-
visa fler...
-
- Ringstad, Geir (författare)
- Oslo Univ Hosp, Dept Radiol, Oslo, Norway.
-
- Berg-Johnsen, Jon (författare)
- Univ Oslo, Fac Med, Oslo, Norway.;Oslo Univ Hosp, Rikshosp, Dept Neurosurg, Oslo, Norway.
-
- Casar Borota, Olivera (författare)
- Uppsala universitet,Klinisk och experimentell patologi
-
- Bollerslev, Jens (författare)
- Oslo Univ Hosp, Dept Endocrinol, Sect Specialized Endocrinol, Oslo, Norway.;Univ Oslo, Fac Med, Oslo, Norway.
-
- Jorgensen, Anders P. (författare)
- Oslo Univ Hosp, Dept Endocrinol, Sect Specialized Endocrinol, Oslo, Norway.
-
visa färre...
-
Oslo Univ Hosp, Dept Endocrinol, Sect Specialized Endocrinol, Oslo, Norway;Univ Oslo, Fac Med, Oslo, Norway. Oslo Univ Hosp, Dept Radiol, Oslo, Norway. (creator_code:org_t)
- 2020-05-18
- 2020
- Engelska.
-
Ingår i: Journal of Clinical Endocrinology and Metabolism. - : ENDOCRINE SOC. - 0021-972X .- 1945-7197. ; 105:8, s. 2587-2594
- Relaterad länk:
-
https://academic.oup...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Context: Gonadotroph pituitary neuroendocrine tumors (PitNETs) can express follicle-stimulating hormone (FSH) and luteinizing hormone (LH) or be hormone negative, but they rarely secrete hormones. During tumor development, epithelial cells develop a mesenchymal phenotype. This process is characterized by decreased membranous E-cadherin and translocation of E-cadherin to the nucleus. Estrogen receptors (ERs) regulate both E-cadherin and FSH expression and secretion. Whether the hormone status of patients with gonadotroph PitNETs is regulated by epithelial-to-mesenchymal transition (EMT) and ERs is unknown. Objectives: To study the effect of EMT on hormone expression in gonadotroph nonfunctioning (NF)-PitNETs. Design: Molecular and clinical analyses of 105 gonadotroph PitNETs. Immunohistochemical studies and real-time quantitative polymerase chain reaction were performed for FSH, LH, E-cadherin, and ER alpha. Further analyses included blood samples, clinical data, and radiological images. Setting: All patients were operated on in the same tertiary referral center. Results: NF-PitNET with high FSH expression had decreased immunohistochemical staining for membranous E-cadherin (P < .0001) and increased staining for nuclear E-cadherin (P < .0001). Furthermore, high FSH expression was associated with increased ER alpha staining (P = .0002) and ER alpha mRNA (P = .0039). Circulating levels of plasma-FSH (P-FSH) correlated with FSH staining in gonadotroph NF-PitNET (P = .0025). Tumor size and invasiveness was not related to FSH staining, E-cadherin, or ER alpha. LH expression was not associated with E-cadherin or ER alpha. Conclusion: In gonadotroph PitNETs, FSH staining is related to E-cadherin, ER alpha expression, and circulating levels of P-FSH. There was no association between FSH staining and invasiveness. The clinical significance of these findings will be investigated in ongoing prospective studies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- pituitary adenoma
- PitNET
- E-cadherin
- FSH
- Patologi
- Pathology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas