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1.	Moulin, P., et al. (författare) Characterisation of patients with familial chylomicronaemia syndrome (FCS) and multifactorial chylomicronaemia syndrome (MCS): Establishment of an FCS clinical diagnostic score 2018 Ingår i: Data in Brief. - : Elsevier BV. - 2352-3409. ; 21, s. 1334-1336 Tidskriftsartikel (refereegranskat)abstract Data presented in this article are supplementary material to our article entitled “Identification and diagnosis of patients with familial chylomicronaemia syndrome (FCS): expert panel recommendations and proposal of an “FCS Score” (Moulin et al., 2018, in press). The data describe the genotypes of patients with familial chylomicronaemia syndrome (FCS) and multifactorial chylomicronaemia syndrome (MCS), from the validation and replication cohorts. © 2018
2.	Moulin, P., et al. (författare) Identification and diagnosis of patients with familial chylomicronaemia syndrome (FCS): Expert panel recommendations and proposal of an “FCS score” 2018 Ingår i: Atherosclerosis. - : Elsevier BV. - 0021-9150. ; 275, s. 265-272 Forskningsöversikt (refereegranskat)
3.	Ahlin, Sofie, 1985, et al. (författare) Bile acid changes after metabolic surgery are linked to improvement in insulin sensitivity 2019 Ingår i: British Journal of Surgery. - : Oxford University Press (OUP). - 0007-1323 .- 1365-2168. ; 106:9, s. 1178- Tidskriftsartikel (refereegranskat)abstract Background: Metabolic surgery is associated with a prompt improvement in insulin resistance, although the mechanism of action remains unknown. The literature on bile acid changes after metabolic surgery is conflicting, and insulin sensitivity is generally assessed by indirect methods. The aim of this study was to investigate the relationship between improvement in insulin sensitivity and concentration of circulating bile acids after biliopancreatic diversion (BPD) and Roux-en-Y gastric bypass (RYGB). Methods: This was a prospective observational study of nine patients who underwent BPD and six who had RYGB. Inclusion criteria for participation were a BMI in excess of 40 kg/m(2), no previous diagnosis of type 2 diabetes and willingness to participate. Exclusion criteria were major endocrine diseases, malignancies and liver cirrhosis. Follow-up visits were carried out after a mean(s.d.) of 185.3(72.9) days. Fasting plasma bile acids were assessed by ultra-high-performance liquid chromatography coupled with a triple quadrupole mass spectrometer, and insulin sensitivity was measured by means of a hyperinsulinaemic-euglycaemic clamp. Results: A significant increase in all bile acids, as well as an amelioration of insulin sensitivity, was observed after metabolic surgery. An increase in conjugated secondary bile acids was significantly associated with an increase in insulin sensitivity. Only the increase in glycodeoxycholic acid was significantly associated with an increase in insulin sensitivity in analysis of individual conjugated secondary bile acids. Conclusion: Glycodeoxycholic acid might drive the improved insulin sensitivity after metabolic surgery.

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Typ av publikation: tidskriftsartikel (2); forskningsöversikt (1)

Typ av innehåll: refereegranskat (3)

Författare/redaktör: Johnson, C. (2); Banach, M (2); Borén, Jan, 1963 (2); Reiner, Z (2); Hughes, E (2); Pinto, X (2); visa fler...; Arca, M (2); Noto, D (2); Gouni-Berthold, I (2); Soran, H (2); Averna, M (2); Bruckert, E. (2); Stroes, E. (2); Moulin, P. (2); Dufour, R. (2); Cefalù, A. B. (2); D'Erasmo, L. (2); Di Costanzo, A. (2); Marçais, C. (2); Cramb, R. (2); van Lennep, J. R. (2); Stefanutti, C. (2); Ahlin, Sofie, 1985 (1); Mingrone, G. (1); Capristo, E. (1); Cefalu, C. (1); Bondia-Pons, I. (1); Marini, L. (1); Gastaldelli, A. (1); Nolan, J. J. (1); Walther, L. A. A. S. (1); Alvarez-Sala Walther ... (1); visa färre...

Lärosäte: Göteborgs universitet (3)

Språk: Engelska (3)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (3)

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