Search: WFRF:(Chabriat Hugues)
> (2015-2019)
> Grond Ginsbach Caspar >
Cervical artery dis...
Cervical artery dissection in patients ≥60 years: Often painless, few mechanical triggers.
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Traenka, Christopher (author)
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Dougoud, Daphne (author)
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Simonetti, Barbara Goeggel (author)
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Metso, Tiina M (author)
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Debette, Stéphanie (author)
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Pezzini, Alessandro (author)
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Kloss, Manja (author)
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Grond-Ginsbach, Caspar (author)
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Majersik, Jennifer J (author)
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Worrall, Bradford B (author)
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Leys, Didier (author)
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Baumgartner, Ralf (author)
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Caso, Valeria (author)
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Béjot, Yannick (author)
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Compter, Annette (author)
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Reiner, Peggy (author)
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Thijs, Vincent (author)
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Southerland, Andrew M (author)
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Bersano, Anna (author)
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Brandt, Tobias (author)
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Gensicke, Henrik (author)
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Touzé, Emmanuel (author)
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Martin, Juan J (author)
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Chabriat, Hugues (author)
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- Tatlisumak, Turgut (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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Lyrer, Philippe (author)
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Arnold, Marcel (author)
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Engelter, Stefan T (author)
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(creator_code:org_t)
- 2017
- 2017
- English.
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In: Neurology. - 1526-632X. ; 88:14, s. 1313-1320
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- In a cohort of patients diagnosed with cervical artery dissection (CeAD), to determine the proportion of patients aged ≥60 years and compare the frequency of characteristics (presenting symptoms, risk factors, and outcome) in patients aged <60 vs ≥60 years.We combined data from 3 large cohorts of consecutive patients diagnosed with CeAD (i.e., Cervical Artery Dissection and Ischemic Stroke Patients-Plus consortium). We dichotomized cases into 2 groups, age ≥60 and <60 years, and compared clinical characteristics, risk factors, vascular features, and 3-month outcome between the groups. First, we performed a combined analysis of pooled individual patient data. Secondary analyses were done within each cohort and across cohorts. Crude and adjusted odds ratios (OR [95% confidence interval]) were calculated.Among 2,391 patients diagnosed with CeAD, we identified 177 patients (7.4%) aged ≥60 years. In this age group, cervical pain (ORadjusted 0.47 [0.33-0.66]), headache (ORadjusted 0.58 [0.42-0.79]), mechanical trigger events (ORadjusted 0.53 [0.36-0.77]), and migraine (ORadjusted 0.58 [0.39-0.85]) were less frequent than in younger patients. In turn, hypercholesterolemia (ORadjusted 1.52 [1.1-2.10]) and hypertension (ORadjusted 3.08 [2.25-4.22]) were more frequent in older patients. Key differences between age groups were confirmed in secondary analyses. In multivariable, adjusted analyses, favorable outcome (i.e., modified Rankin Scale score 0-2) was less frequent in the older age group (ORadjusted 0.45 [0.25, 0.83]).In our study population of patients diagnosed with CeAD, 1 in 14 was aged ≥60 years. In these patients, pain and mechanical triggers might be missing, rendering the diagnosis more challenging and increasing the risk of missed CeAD diagnosis in older patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Adult
- Age Factors
- Aged
- Brain Ischemia
- complications
- Cohort Studies
- Female
- Humans
- Male
- Middle Aged
- Neck Pain
- epidemiology
- etiology
- Odds Ratio
- Risk Factors
- Stroke
- complications
- etiology
- Vertebral Artery Dissection
- complications
- diagnosis
- epidemiology
Publication and Content Type
- ref (subject category)
- art (subject category)
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Neurology
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- By the author/editor
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Traenka, Christo ...
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Dougoud, Daphne
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Simonetti, Barba ...
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Metso, Tiina M
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Debette, Stéphan ...
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Pezzini, Alessan ...
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show more...
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Kloss, Manja
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Grond-Ginsbach, ...
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Majersik, Jennif ...
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Worrall, Bradfor ...
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Leys, Didier
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Baumgartner, Ral ...
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Caso, Valeria
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Béjot, Yannick
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Compter, Annette
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Reiner, Peggy
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Thijs, Vincent
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Southerland, And ...
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Bersano, Anna
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Brandt, Tobias
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Gensicke, Henrik
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Touzé, Emmanuel
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Martin, Juan J
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Chabriat, Hugues
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Tatlisumak, Turg ...
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Lyrer, Philippe
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Arnold, Marcel
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Engelter, Stefan ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Neurology
- By the university
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University of Gothenburg