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A genome-wide association study of marginal zone lymphoma shows association to the HLA region

Vijai, Joseph (author)
Wang, Zhaoming (author)
Berndt, Sonja I. (author)
show more...
Skibola, Christine F. (author)
Slager, Susan L. (author)
de Sanjose, Silvia (author)
Melbye, Mads (author)
Glimelius, Bengt (author)
Bracci, Paige M. (author)
Conde, Lucia (author)
Birmann, Brenda M. (author)
Wang, Sophia S. (author)
Brooks-Wilson, Angela R. (author)
Lan, Qing (author)
de Bakker, Paul I. W. (author)
Vermeulen, Roel C. H. (author)
Portlock, Carol (author)
Ansell, Stephen M. (author)
Link, Brian K. (author)
Riby, Jacques (author)
North, Kari E. (author)
Gu, Jian (author)
Hjalgrim, Henrik (author)
Cozen, Wendy (author)
Becker, Nikolaus (author)
Teras, Lauren R. (author)
Spinelli, John J. (author)
Turner, Jenny (author)
Zhang, Yawei (author)
Purdue, Mark P. (author)
Giles, Graham G. (author)
Kelly, Rachel S. (author)
Zeleniuch-Jacquotte, Anne (author)
Ennas, Maria Grazia (author)
Monnereau, Alain (author)
Bertrand, Kimberly A. (author)
Albanes, Demetrius (author)
Lightfoot, Tracy (author)
Yeager, Meredith (author)
Chung, Charles C. (author)
Burdett, Laurie (author)
Hutchinson, Amy (author)
Lawrence, Charles (author)
Montalvan, Rebecca (author)
Liang, Liming (author)
Huang, Jinyan (author)
Ma, Baoshan (author)
Villano, Danylo J. (author)
Maria, Ann (author)
Corines, Marina (author)
Thomas, Tinu (author)
Novak, Anne J. (author)
Dogan, Ahmet (author)
Liebow, Mark (author)
Thompson, Carrie A. (author)
Witzig, Thomas E. (author)
Habermann, Thomas M. (author)
Weiner, George J. (author)
Smith, Martyn T. (author)
Holly, Elizabeth A. (author)
Jackson, Rebecca D. (author)
Tinker, Lesley F. (author)
Ye, Yuanqing (author)
Adami, Hans-Olov (author)
Smedby, Karin E. (author)
De Roos, Anneclaire J. (author)
Hartge, Patricia (author)
Morton, Lindsay M. (author)
Severson, Richard K. (author)
Benavente, Yolanda (author)
Boffetta, Paolo (author)
Brennan, Paul (author)
Foretova, Lenka (author)
Maynadie, Marc (author)
Mckay, James (author)
Staines, Anthony (author)
Diver, W. Ryan (author)
Vajdic, Claire M. (author)
Armstrong, Bruce K. (author)
Kricker, Anne (author)
Zheng, Tongzhang (author)
Holford, Theodore R. (author)
Severi, Gianluca (author)
Vineis, Paolo (author)
Ferri, Giovanni M. (author)
Ricco, Rosalia (author)
Miligi, Lucia (author)
Clavel, Jacqueline (author)
Giovannucci, Edward (author)
Kraft, Peter (author)
Virtamo, Jarmo (author)
Smith, Alex (author)
Kane, Eleanor (author)
Roman, Eve (author)
Chiu, Brian C. H. (author)
Fraumeni, Joseph F. (author)
Wu, Xifeng (author)
Cerhan, James R. (author)
Offit, Kenneth (author)
Chanock, Stephen J. (author)
Rothman, Nathaniel (author)
Nieters, Alexandra (author)
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 (publisher)
2015
2015
English.
In: Nature Communications. - 2041-1723. ; 6
  • swepub:Mat__t
Abstract Subject headings
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  • Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P - 3.95 x 10(-15)) and HLA-B (rs2922994, P - 2.43 x 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.

Subject headings

Medical and Health Sciences  (hsv)
Medicin och hälsovetenskap  (hsv)

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By the author/editor
Vijai, Joseph
Wang, Zhaoming
Berndt, Sonja I.
Skibola, Christi ...
Slager, Susan L.
de Sanjose, Silv ...
show more...
Melbye, Mads
Glimelius, Bengt
Bracci, Paige M.
Conde, Lucia
Birmann, Brenda ...
Wang, Sophia S.
Brooks-Wilson, A ...
Lan, Qing
de Bakker, Paul ...
Vermeulen, Roel ...
Portlock, Carol
Ansell, Stephen ...
Link, Brian K.
Riby, Jacques
North, Kari E.
Gu, Jian
Hjalgrim, Henrik
Cozen, Wendy
Becker, Nikolaus
Teras, Lauren R.
Spinelli, John J ...
Turner, Jenny
Zhang, Yawei
Purdue, Mark P.
Giles, Graham G.
Kelly, Rachel S.
Zeleniuch-Jacquo ...
Ennas, Maria Gra ...
Monnereau, Alain
Bertrand, Kimber ...
Albanes, Demetri ...
Lightfoot, Tracy
Yeager, Meredith
Chung, Charles C ...
Burdett, Laurie
Hutchinson, Amy
Lawrence, Charle ...
Montalvan, Rebec ...
Liang, Liming
Huang, Jinyan
Ma, Baoshan
Villano, Danylo ...
Maria, Ann
Corines, Marina
Thomas, Tinu
Novak, Anne J.
Dogan, Ahmet
Liebow, Mark
Thompson, Carrie ...
Witzig, Thomas E ...
Habermann, Thoma ...
Weiner, George J ...
Smith, Martyn T.
Holly, Elizabeth ...
Jackson, Rebecca ...
Tinker, Lesley F ...
Ye, Yuanqing
Adami, Hans-Olov
Smedby, Karin E.
De Roos, Annecla ...
Hartge, Patricia
Morton, Lindsay ...
Severson, Richar ...
Benavente, Yolan ...
Boffetta, Paolo
Brennan, Paul
Foretova, Lenka
Maynadie, Marc
Mckay, James
Staines, Anthony
Diver, W. Ryan
Vajdic, Claire M ...
Armstrong, Bruce ...
Kricker, Anne
Zheng, Tongzhang
Holford, Theodor ...
Severi, Gianluca
Vineis, Paolo
Ferri, Giovanni ...
Ricco, Rosalia
Miligi, Lucia
Clavel, Jacqueli ...
Giovannucci, Edw ...
Kraft, Peter
Virtamo, Jarmo
Smith, Alex
Kane, Eleanor
Roman, Eve
Chiu, Brian C. H ...
Fraumeni, Joseph ...
Wu, Xifeng
Cerhan, James R.
Offit, Kenneth
Chanock, Stephen ...
Rothman, Nathani ...
Nieters, Alexand ...
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