SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Chen Wei) "

Sökning: WFRF:(Chen Wei)

Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  •  
2.
  • Sampson, Joshua N., et al. (författare)
  • Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types
  • 2015
  • Ingår i: Journal of the National Cancer Institute. - 0027-8874 .- 1460-2105. ; 107:12
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Background: Studies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites. Methods: Between 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers. Results: GWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, h(l)(2), on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24% (95% confidence interval [CI] = 14% to 37%) and 7% (95% CI = 4% to 11%) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (rho = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and pediatric osteosarcoma (rho = 0.53, SE = 0.21), DLBCL and chronic lymphocytic leukemia (CLL) (rho = 0.51, SE = 0.18), and bladder and lung (rho = 0.35, SE = 0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures. Conclusion: Our results provide important insights into the genetic architecture of cancers and suggest new avenues for investigation.</p>
  •  
3.
  • Sampson, Joshua N., et al. (författare)
  • Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types
  • 2015
  • Ingår i: Journal of the National Cancer Institute. - 0027-8874 .- 1460-2105. ; 107:12
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Background: Studies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites.</p><p>Methods: Between 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers.</p><p>Results: GWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, h(l)(2), on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24% (95% confidence interval [CI] = 14% to 37%) and 7% (95% CI = 4% to 11%) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (rho = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and pediatric osteosarcoma (rho = 0.53, SE = 0.21), DLBCL and chronic lymphocytic leukemia (CLL) (rho = 0.51, SE = 0.18), and bladder and lung (rho = 0.35, SE = 0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures.</p><p>Conclusion: Our results provide important insights into the genetic architecture of cancers and suggest new avenues for investigation.</p>
  •  
4.
  • Ablikim, M., et al. (författare)
  • Observation of a Neutral Structure near the D(D)over-bar* Mass Threshold in e(+)e(-) -&gt; (D(D)over-bar*)(0)pi(0) at root s=4.226 and 4.257 GeV
  • 2015
  • Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 115:22
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>A neutral structure in the D (D) over bar* system around the D (D) over bar* mass threshold is observed with a statistical significance greater than 10 sigma in the processes e(+)e(-) -&gt; D+D*(-)pi(0) + c.c. and e(+)e(-) -&gt; D-0(D) over bar*(0)pi(0) + c.c. at root s = 4.226 and 4.257 GeV in the BESIII experiment. The structure is denoted as Z(c)(3885)(0). Assuming the presence of a resonance, its pole mass and width are determined to be [3885.7(-5.7)(+4.3) (stat) +/- 8.4(syst)] MeV/c(2) and [35(-12)(+11) (stat) +/- 15(syst)] MeV, respectively. The Born cross sections are measured to be sigma[e(+)e(-) -&gt; Z(c)(3885)(0)pi(0); Z(c)(3885)(0) -&gt; D (D) over bar*] = [77 +/- 13(stat) +/- 17(syst)] pb at 4.226 GeV and [47 +/- 9(stat) +/- 10(syst)] pb at 4.257 GeV. The ratio of decay rates B[Z(c)(3885)(0) -&gt; D+D*(-) + c.c.]/B[Z(c)(3885)(0) -&gt; D-0(D) over bar*(0) + c.c.] is determined to be 0.96 +/- 0.18(stat) +/- 0.12(syst), consistent with no isospin violation in the process, Z(c)(3885)(0) -&gt; D (D) over bar*.</p>
  •  
5.
  • Ablikim, M., et al. (författare)
  • Study of D+ -&gt; K-pi(+)e(+)nu(e)
  • 2016
  • Ingår i: PHYSICAL REVIEW D. - 2470-0010. ; 94:3
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>We present an analysis of the decay D+ -&gt; K-pi(+)e(+)nu(e) based on data collected by the BESIII experiment at the psi(3770) resonance. Using a nearly background-free sample of 18262 events, we measure the branching fraction B(D+ -&gt; K-pi+e+nu e) = (3.77 +/- 0.03 +/- 0.08)%. For 0.8 &lt; m(K pi) &lt; 1.0 GeV/c(2), the partial branching fraction is B(D+ -&gt; K-pi+e+nu e)([0.8,1.0]) = (3.39 +/- 0.03 +/- 0.08)%. A partial wave analysis shows that the dominant (K) over bar* (892)degrees component is accompanied by an S-wave contribution accounting for (6.05 +/- 0.22 +/- 0.18)% of the total rate and that other components are negligible. The parameters of the (K) over bar* (892)degrees resonance and of the form factors based on the spectroscopic pole dominance predictions are also measured. We also present a measurement of the (K) over bar* (892)degrees helicity basis form factors in a model-independent way.</p>
  •  
6.
  •  
7.
  • Wang, Zhaoming, et al. (författare)
  • Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33
  • 2014
  • Ingår i: Human Molecular Genetics. - 0964-6906 .- 1460-2083. ; 23:24, s. 6616-6633
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Genome-wide association studies (GWAS) have mapped risk alleles for at least 10 distinct cancers to a small region of 63 000 bp on chromosome 5p15.33. This region harbors the TERT and CLPTM1L genes; the former encodes the catalytic subunit of telomerase reverse transcriptase and the latter may play a role in apoptosis. To investigate further the genetic architecture of common susceptibility alleles in this region, we conducted an agnostic subset-based meta-analysis (association analysis based on subsets) across six distinct cancers in 34 248 cases and 45 036 controls. Based on sequential conditional analysis, we identified as many as six independent risk loci marked by common single-nucleotide polymorphisms: five in the TERT gene (Region 1: rs7726159, P = 2.10 × 10(-39); Region 3: rs2853677, P = 3.30 × 10(-36) and PConditional = 2.36 × 10(-8); Region 4: rs2736098, P = 3.87 × 10(-12) and PConditional = 5.19 × 10(-6), Region 5: rs13172201, P = 0.041 and PConditional = 2.04 × 10(-6); and Region 6: rs10069690, P = 7.49 × 10(-15) and PConditional = 5.35 × 10(-7)) and one in the neighboring CLPTM1L gene (Region 2: rs451360; P = 1.90 × 10(-18) and PConditional = 7.06 × 10(-16)). Between three and five cancers mapped to each independent locus with both risk-enhancing and protective effects. Allele-specific effects on DNA methylation were seen for a subset of risk loci, indicating that methylation and subsequent effects on gene expression may contribute to the biology of risk variants on 5p15.33. Our results provide strong support for extensive pleiotropy across this region of 5p15.33, to an extent not previously observed in other cancer susceptibility loci.</p>
  •  
8.
  • Ablikim, M., et al. (författare)
  • Amplitude analysis of D<sup>0</sup> -&gt; K<sup> -</sup>π<sup>+</sup>π<sup>+</sup>π<sup>-</sup>
  • 2017
  • Ingår i: Physical Review D : covering particles, fields, gravitation, and cosmology. - 2470-0010 .- 2470-0029. ; 95:7
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>We present an amplitude analysis of the decay D-0 -&gt; K- pi(+)pi(+)pi(-) based on a data sample of 2.93 fb(-1) acquired by the BESIII detector at the psi(3770) resonance. With a nearly background free sample of about 16000 events, we investigate the substructure of the decay and determine the relative fractions and the phases among the different intermediate processes. Our amplitude model includes the two-body decays D-0 -&gt; (K) over bar*(0)rho(0), D-0 -&gt; K- a(1)(+) (1260) and D-0 -&gt; K-1(-)(1270)pi(+), the three-body decays D-0 -&gt; K-1(-)*(0)pi(+)pi(-) and D-0 -&gt; K- pi(+)rho(0), as well as the four-body nonresonant decay D-0 -&gt; K- pi(+)pi(+)pi(-). The dominant intermediate process is D-0 -&gt; K(-)a(1)(+)(1260)accounting for a fit fraction of 54.6%.</p>
  •  
9.
  • Ablikim, M., et al. (författare)
  • Determination of the Spin and Parity of the Z(c)(3900)
  • 2017
  • Ingår i: Physical Review Letters. - AMER PHYSICAL SOC. - 0031-9007 .- 1079-7114. ; 119:7
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>The spin and parity of the Z(c)(3900)(+/-) state are determined to be J(P) = 1(+) with a statistical significance larger than 7 sigma over other quantum numbers in a partial wave analysis of the process e(+)e(-) -&gt; pi(+)pi(-) J/psi We use a data sample of 1.92 fb(-1) accumulated at root s = 4.23 and 4.26 GeV with the BESIII experiment. When parametrizing the Z(c)(3900)(+/-) with a Flatte-like formula, we determine its pole mass M-pole = (3881.2 +/- 4.2(stat) +/- 52.7(syst)) MeV/c(2) and pole width Gamma(pole) = (51.8 +/- 4.6(stat) +/- 36.0(syst)) MeV. We also measure cross sections for the process e(+)e(-) -&gt; Z(c)(3900)(+)pi(-) + c.c. -&gt; J/psi pi(+)pi(-) and determine an upper limit at the 90% confidence level for the process e(+)e(-) -&gt; Z(c)(4020)(+)pi(-) + c.c. -&gt; J/psi pi(+)pi(-).</p>
  •  
10.
  • Ablikim, M., et al. (författare)
  • Observation of an Anomalous Line Shape of the eta 'pi(+)pi(-) Mass Spectrum near the p(p)over-bar Mass Threshold in J/psi -&gt; gamma eta 'pi(+)pi(-)
  • 2016
  • Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 117:4
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Using 1.09 x 10(9) J/psi events collected by the BESIII experiment in 2012, we study the J / psi -&gt; gamma eta'pi(+)pi(-) process and observe a significant abrupt change in the slope of the eta'pi(+)pi(-) invariant mass distribution at the proton-antiproton (p (p) over bar) mass threshold. We use two models to characterize the eta'pi(+)pi(-) line shape around 1.85 GeV/c(2): one that explicitly incorporates the opening of a decay threshold in the mass spectrum (Flatte formula), and another that is the coherent sum of two resonant amplitudes. Both fits show almost equally good agreement with data, and suggest the existence of either a broad state around 1.85 GeV/c(2) with strong couplings to the c final states or a narrow state just below the p (p) over bar mass threshold. Although we cannot distinguish between the fits, either one supports the existence of a p (p) over bar moleculelike state or bound state with greater than 7 sigma significance.</p>
  •  
Skapa referenser, mejla, bekava och länka
Åtkomst
fritt online (190)
Typ av publikation
tidskriftsartikel (796)
konferensbidrag (84)
forskningsöversikt (9)
annan publikation (5)
doktorsavhandling (5)
samlingsverk (redaktörskap) (1)
visa fler...
bokkapitel (1)
licentiatavhandling (1)
visa färre...
Typ av innehåll
refereegranskat (874)
övrigt vetenskapligt (98)
Författare/redaktör
Wang, Z (142)
Liu, X (138)
Hu, T., (137)
Cai, X. (136)
An, Q., (136)
Feng, C. Q., (136)
visa fler...
Huang, G. S., (136)
Li, X. L., (136)
Liu, K., (136)
Liu, Q., (136)
Liu, S. B., (136)
Chen, G. (135)
Fang, Y (135)
Li, H. B., (135)
Ablikim, M. (135)
Ban, Y., (135)
Chen, J. C., (135)
Chen, Y. B., (135)
Deng, Z. Y., (135)
Dong, J., (135)
Fang, J., (135)
Fang, S. S., (135)
Fu, C. D., (135)
Gao, Y., (135)
Gu, Y. T., (135)
Harris, F. A., (135)
He, K. L., (135)
Heng, Y. K., (135)
Hu, H. M., (135)
Huang, X. T., (135)
Ji, X. B., (135)
Jiang, X. S., (135)
Jin, S., (135)
Li, Cheng, (135)
Li, W. D., (135)
Li, W. G., (135)
Li, X. N., (135)
Li, X. Q., (135)
Liang, Y. F., (135)
Liu, B. J., (135)
Liu, C. X., (135)
Liu, Fang, (135)
Liu, Feng, (135)
Liu, H. M., (135)
Liu, Z. A., (135)
Lu, J. G., (135)
Luo, C. L., (135)
Ma, F. C., (135)
Ma, H. L., (135)
Ma, Q. M., (135)
visa färre...
Lärosäte
Uppsala universitet (261)
Lunds universitet (133)
Kungliga Tekniska Högskolan (122)
Umeå universitet (94)
Luleå tekniska universitet (68)
Karolinska Institutet (64)
visa fler...
Linköpings universitet (50)
Stockholms universitet (39)
Göteborgs universitet (38)
Chalmers tekniska högskola (35)
Mittuniversitetet (6)
Högskolan Dalarna (5)
Örebro universitet (4)
swepub_uni:mau_t (4)
RISE (3)
Mälardalens högskola (2)
Högskolan i Jönköping (2)
Högskolan i Halmstad (2)
Linnéuniversitetet (2)
Karlstads universitet (2)
Högskolan i Skövde (1)
Högskolan i Borås (1)
Högskolan i Gävle (1)
visa färre...
Språk
Engelska (891)
Kinesiska (3)
Odefinierat språk (1)
Forskningsämne (UKÄ/SCB)
Naturvetenskap (427)
Medicin och hälsovetenskap (277)
Teknik (179)
Samhällsvetenskap (7)
Lantbruksvetenskap (3)

År

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy