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Träfflista för sökning "WFRF:(Chen Yilun) ;pers:(Fernö Mårten)"

Sökning: WFRF:(Chen Yilun) > Fernö Mårten

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1.	Alkner, Sara, et al. (författare) Contralateral breast cancer can represent a metastatic spread of the first primary tumor: determination of clonal relationship between contralateral breast cancers using next-generation whole genome sequencing. 2015 Ingår i: Breast Cancer Research. - : Springer Science and Business Media LLC. - 1465-5411 .- 1465-542X. ; 17:1 Tidskriftsartikel (refereegranskat)abstract By convention, a contralateral breast cancer (CBC) is treated as a new primary tumor, independent of the first cancer (BC1). Although there have been indications that the second tumor (BC2) sometimes may represent a metastatic spread of BC1, this has never been conclusively shown. We sought to apply next-generation sequencing to determine a "genetic barcode" for each tumor and reveal the clonal relationship of CBCs.
2.	Olsson, Eleonor, et al. (författare) Serial monitoring of circulating tumor DNA in patients with primary breast cancer for detection of occult metastatic disease. 2015 Ingår i: EMBO Molecular Medicine. - : EMBO. - 1757-4684 .- 1757-4676. ; 7:8, s. 1034-1047 Tidskriftsartikel (refereegranskat)abstract Metastatic breast cancer is usually diagnosed after becoming symptomatic, at which point it is rarely curable. Cell-free circulating tumor DNA (ctDNA) contains tumor-specific chromosomal rearrangements that may be interrogated in blood plasma. We evaluated serial monitoring of ctDNA for earlier detection of metastasis in a retrospective study of 20 patients diagnosed with primary breast cancer and long follow-up. Using an approach combining low-coverage whole-genome sequencing of primary tumors and quantification of tumor-specific rearrangements in plasma by droplet digital PCR, we identify for the first time that ctDNA monitoring is highly accurate for postsurgical discrimination between patients with (93%) and without (100%) eventual clinically detected recurrence. ctDNA-based detection preceded clinical detection of metastasis in 86% of patients with an average lead time of 11 months (range 0-37 months), whereas patients with long-term disease-free survival had undetectable ctDNA postoperatively. ctDNA quantity was predictive of poor survival. These findings establish the rationale for larger validation studies in early breast cancer to evaluate ctDNA as a monitoring tool for early metastasis detection, therapy modification, and to aid in avoidance of overtreatment.

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Typ av publikation: tidskriftsartikel (2)

Typ av innehåll: refereegranskat (2)

Författare/redaktör: Fernö, Mårten (2)Ta bort avgränsningen; Rydén, Lisa (2); Tang, Man-Hung Eric (2); Dahlgren, Malin (2); Chen, Yilun (2); Olsson, Eleonor (2); visa fler...; Winter, Christof (2); Saal, Lao (2); Gruvberger, Sofia (2); Bendahl, Pär Ola (1); Ehinger, Anna (1); Alkner, Sara (1); van Westen, Danielle (1); Borg, Åke (1); Grabau, Dorthe (1); Brueffer, Christian (1); Baker, Sara (1); Jernström, Helena (1); Ingvar, Christian (1); Rose, Carsten (1); George, Anthony (1); Howlin, Jillian (1); Schulz, Ralph (1); visa färre...

Lärosäte: Lunds universitet (2)

Språk: Engelska (2)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (2)

År: 2015 (2)

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