| 1. |
- Baigent, Colin, et al.
(författare)
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The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection) : a randomised placebo-controlled trial
- 2011
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Ingår i: The Lancet. - 0140-6736 .- 1474-547X. ; 377:9784, s. 2181-2192
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Tidskriftsartikel (refereegranskat)abstract
- Background Lowering LDL cholesterol with statin regimens reduces the risk of myocardial infarction, ischaemic stroke, and the need for coronary revascularisation in people without kidney disease, but its effects in people with moderate-to-severe kidney disease are uncertain. The SHARP trial aimed to assess the efficacy and safety of the combination of simvastatin plus ezetimibe in such patients. Methods This randomised double-blind trial included 9270 patients with chronic kidney disease (3023 on dialysis and 6247 not) with no known history of myocardial infarction or coronary revascularisation. Patients were randomly assigned to simvastatin 20 mg plus ezetimibe 10 mg daily versus matching placebo. The key prespecified outcome was first major atherosclerotic event (non-fatal myocardial infarction or coronary death, non-haemorrhagic stroke, or any arterial revascularisation procedure). All analyses were by intention to treat. This trial is registered at ClinicalTrials.gov, NCT00125593, and I SRCTN54137607. Findings 4650 patients were assigned to receive simvastatin plus ezetimibe and 4620 to placebo. Allocation to simvastatin plus ezetimibe yielded an average LDL cholesterol difference of 0.85 mmol/L (SE 0.02; with about two-thirds compliance) during a median follow-up of 4.9 years and produced a 17% proportional reduction in major atherosclerotic events (526 [11.3%] simvastatin plus ezetimibe vs 619 [13.4%] placebo; rate ratio [RR] 0.83, 95% CI 0.74-0.94; log-rank p=0.0021). Non-significantly fewer patients allocated to simvastatin plus ezetimibe had a non-fatal myocardial infarction or died from coronary heart disease (213 [4.6%] vs 230 [5.0%]; RR 0.92,95% CI 0.76-1.11; p=0.37) and there were significant reductions in non-haemorrhagic stroke (131 [2.8%] vs 174 [3.8%]; RR 0.75,95% CI 0.60-0.94; p=0.01) and arterial revascularisation procedures (284 [6.1%] vs 352 [7.6%]; RR 0.79, 95% CI 0.68-0.93; p=0.0036). After weighting for subgroup-specific reductions in LDL cholesterol, there was no good evidence that the proportional effects on major atherosclerotic events differed from the summary rate ratio in any subgroup examined, and, in particular, they were similar in patients on dialysis and those who were not. The excess risk of myopathy was only two per 10 000 patients per year of treatment with this combination (9 [0.2%] vs 5 [0.1%]). There was no evidence of excess risks of hepatitis (21 [0.5%] vs 18 [0.4%]), gallstones (106 [2.3%] vs 106 [2.3%]), or cancer (438 [9.4%] vs 439 [9.5%], p=0.89) and there was no significant excess of death from any non-vascular cause (668 [14.4%] vs 612 [13.2%], p=0.13). Interpretation Reduction of LDL cholesterol with simvastatin 20 mg plus ezetimibe 10 mg daily safely reduced the incidence of major atherosclerotic events in a wide range of patients with advanced chronic kidney disease.
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| 2. |
- Chen, Shan, et al.
(författare)
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An efficient enzymatic aminolysis for kinetic resolution of aromatic alpha-hydroxyl acid in non-aqueous media
- 2016
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Ingår i: Tetrahedron Letters. - : Elsevier. - 0040-4039 .- 1359-8562. ; 57:48, s. 5312-5314
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Tidskriftsartikel (refereegranskat)abstract
- A new and highly efficient enzymatic aminolysis approach for kinetic resolution of aromatic a-hydroxy acid in non-aqueous media has been developed. The corresponding alpha-hydroxyl acid ester was employed as the substrate, and commercially available Candida antarctica lipase B is used as the biocatalyst, anhydrous ammonia is the resolving agent. Reactions can be proceeded smoothly in organic solvent at ambient temperatures. High concentration of substrate is allowed due to the application of organic media and the products are obtained in yields of up to 49% with ee values of up to 99%, and with E value of >300, representing an appealing and promising protocol for large-scale preparations.
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| 3. |
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The Seventeenth Data Release of the Sloan Digital Sky Surveys : Complete Release of MaNGA, MaStar, and APOGEE-2 Data
- 2022
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Ingår i: Astrophysical Journal Supplement Series. - : Institute of Physics (IOP). - 0067-0049 .- 1538-4365. ; 259:2
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Tidskriftsartikel (refereegranskat)abstract
- This paper documents the seventeenth data release (DR17) from the Sloan Digital Sky Surveys; the fifth and final release from the fourth phase (SDSS-IV). DR17 contains the complete release of the Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey, which reached its goal of surveying over 10,000 nearby galaxies. The complete release of the MaNGA Stellar Library accompanies this data, providing observations of almost 30,000 stars through the MaNGA instrument during bright time. DR17 also contains the complete release of the Apache Point Observatory Galactic Evolution Experiment 2 survey that publicly releases infrared spectra of over 650,000 stars. The main sample from the Extended Baryon Oscillation Spectroscopic Survey (eBOSS), as well as the subsurvey Time Domain Spectroscopic Survey data were fully released in DR16. New single-fiber optical spectroscopy released in DR17 is from the SPectroscipic IDentification of ERosita Survey subsurvey and the eBOSS-RM program. Along with the primary data sets, DR17 includes 25 new or updated value-added catalogs. This paper concludes the release of SDSS-IV survey data. SDSS continues into its fifth phase with observations already underway for the Milky Way Mapper, Local Volume Mapper, and Black Hole Mapper surveys.
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| 4. |
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| 5. |
- Feng, Yi, et al.
(författare)
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Development and experimental verification of analytical models for printable interdigital capacitor sensors on paperboard
- 2009
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Ingår i: 2009 IEEE Sensors. - : IEEE Sensors Council. - 9781424445486 ; , s. 1034-1039
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Konferensbidrag (refereegranskat)abstract
- Printed interdigital capacitor DWI on paperboard is a promising solution for low-cost sensors in intelligent packaging applications. The currently available analytical models of multi-layered IDCs are targeted to those fabricated by conventional semiconductor process. For this reason, we have adapted two promising models and assessed their accuracies by comparison with experimental data. We modified these models by treating the paper as non-infinite thick substrate and taking the effect of printed metal thickness into account. The models are studied further to reveal the relationship between the response of capacitance change and various geometric parameters which enables a quick way of obtaining the optimum IDC structure design. The modified Gevorgian model fits our experimental data best, and the sensitivity of IDCs is largely affected by its spatial wavelength and the thickness of sensing material layer, while the finger number, length and metallization ratio have minor impact.
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| 6. |
- Lin, Xiaojing, et al.
(författare)
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Metal-enriched Neutral Gas Reservoir around a Strongly Lensed Low-mass Galaxy at z = 4 Identified by JWST/NIRISS and VLT/MUSE
- 2023
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Ingår i: Astrophysical Journal Letters. - : American Astronomical Society. - 2041-8213 .- 2041-8205. ; 944:2
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Tidskriftsartikel (refereegranskat)abstract
- Direct observations of low-mass, low-metallicity galaxies at z ≳ 4 provide an indispensable opportunity for detailed inspection of the ionization radiation, gas flow, and metal enrichment in sources similar to those that reionized the universe. Combining the James Webb Space Telescope (JWST), Very Large Telescope/MUSE, and Atacama Large Millimeter/submillimeter Array, we present detailed observations of a strongly lensed, low-mass (≈107.6 M ⊙) galaxy at z = 3.98 (also see Vanzella et al.). We identify strong narrow nebular emission, including C iv λ λ1548, 1550, He ii λ1640, O iii] λ λ1661, 1666, [Ne iii] λ3868, [O ii] λ3727, and the Balmer series of hydrogen from this galaxy, indicating a metal-poor H ii region (≲0.12 Z ⊙) powered by massive stars. Further, we detect a metal-enriched damped Lyα system (DLA) associated with the galaxy with the H i column density of N H I ≈ 1021.8 cm−2. The metallicity of the associated DLA may reach the supersolar metallicity (≳Z ⊙). Moreover, thanks to JWST and gravitational lensing, we present the resolved UV slope (β) map at the spatial resolution of ≈100 pc at z = 4, with steep UV slopes reaching β ≈ −2.5 around three star-forming clumps. Combining with low-redshift analogs, our observations suggest that low-mass, low-metallicity galaxies, which dominate reionization, could be surrounded by a high covering fraction of the metal-enriched, neutral-gaseous clouds. This implies that the metal enrichment of low-mass galaxies is highly efficient, and further supports that in low-mass galaxies, only a small fraction of ionizing radiation can escape through the interstellar or circumgalactic channels with low-column-density neutral gas.
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| 7. |
- Lu, Yiping, et al.
(författare)
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Directly cast bulk eutectic and near-eutectic high entropy alloys with balanced strength and ductility in a wide temperature range
- 2017
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Ingår i: Acta Materialia. - : Elsevier BV. - 1359-6454. ; 124, s. 143-150
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Tidskriftsartikel (refereegranskat)abstract
- High entropy alloys (HEAs) usually possess weak liquidity and castability, and considerable compositional inhomogeneity, mainly because they contain multiple elements with high concentrations. As a result, large-scale production of HEAs by casting is limited. To address the issue, the concept of eutectic high entropy alloys (EHEAs) was proposed, which has led to some promise in achieving good quality industrial scale HEAs ingots, and more importantly also good mechanical properties. In the practical large-scale casting, the actual composition of designed EHEAs could potentially deviate from the eutectic composition. The influence of such deviation on mechanical properties of EHEAs is important for industrial production, which constitutes the topic of the current work. Here we prepared industrial-scale HEAs ingots near the eutectic composition: hypoeutectic alloy, eutectic alloy and hypereutectic alloy. Our results showed that the deviation from eutectic composition does not significantly affect the mechanical properties, castability and the good mechanical properties of EHEAs can be achieved in a wide compositional range, and at both room and cryogenic temperatures. Our results suggested that EHEAs with simultaneous high strength and high ductility, and good liquidity and castability can be readily adapted to large-scale industrial production. The deformation behavior and microstructure evolution of the eutectic and near-eutectic HEAs were thoroughly studied using a combination of techniques, including strain measurement by digital image correlation, in-situ synchrotron X-ray diffraction, and transmission electron microscopy. The wavy strain distribution and the therefore resulted delay of necking in EHEAs were reported for the first time.
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| 8. |
- Lu, Yiping, et al.
(författare)
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Preparing bulk ultrafine-microstructure high-entropy alloys: Via direct solidification
- 2018
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Ingår i: Nanoscale. - : Royal Society of Chemistry (RSC). - 2040-3372 .- 2040-3364. ; 10:4, s. 1912-1919
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Tidskriftsartikel (refereegranskat)abstract
- In the past three decades, nanostructured (NS) and ultrafine-microstructure (UFM) materials have received extensive attention due to their excellent mechanical properties such as high strength. However, preparing low-cost and bulk NS and UFM materials remains to be a challenge, which limits their industrial applications. Here, we report a new strategy to prepare bulk UFM alloys via the direct solidification of high-entropy alloys (HEAs). As a proof of concept, we designed AlCoCr x FeNi (1.8 ≤ x ≤ 2.0) HEAs and achieved a complete UFM in bulk materials. The compositional requirements for obtaining the formation of the UFM are highly demanding, necessitating the coupling of near eutectic alloy composition and the high temperature decomposition of supersaturated primary and secondary phases. Our strategy provides a low-cost and highly efficient method to prepare bulk UFM alloys, with great potential to accelerate the engineering application of these materials.
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| 9. |
- Rehman, Hafeez Ur, et al.
(författare)
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Self-Healing Shape Memory PUPCL Copolymer with High Cycle Life
- 2018
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Ingår i: Advanced Functional Materials. - : WILEY-V C H VERLAG GMBH. - 1616-301X .- 1616-3028. ; 28:7
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Tidskriftsartikel (refereegranskat)abstract
- New polyurethane-based polycaprolactone copolymer networks, with shape recovery properties, are presented here. Once deformed at ambient temperature, they show 100% shape fixation until heated above the melting point, where they recover the initial shape within 22 s. In contrast to current shape memory materials, the new materials do not require deformation at elevated temperature. The stable polymer structure of polyurethane yields a copolymer network that has strength of 10 MPa with an elongation at break of 35%. The copolymer networks are self-healing at a slightly elevated temperature (70 degrees C) without any external force, which is required for existing self-healing materials. This allows for the new materials to have a long life of repeated healing cycles. The presented copolymers show features that are promising for applications as temperature sensors and activating elements.
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| 10. |
- Xu, Shaohui, et al.
(författare)
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Modeling and Optimization of Thermoelements by a Combined Analytical and Numerical Method
- 2014
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Ingår i: Journal of Electronic Materials. - : Springer Science and Business Media LLC. - 0361-5235 .- 1543-186X. ; 43:2, s. 404-413
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Tidskriftsartikel (refereegranskat)abstract
- A combined analytical and numerical process has been developed to model and optimize thermoelements. In this way, the performance of commercial n- and p-type thermoelectric materials can be optimized to deliver the maximum output power and conversion efficiency. The validity of the method is demonstrated using a silicon germanium unicouple.
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