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Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia

Berndt, Sonja I. (author)
Skibola, Christine F. (author)
Joseph, Vijai (author)
show more...
Camp, Nicola J. (author)
Nieters, Alexandra (author)
Wang, Zhaoming (author)
Cozen, Wendy (author)
Monnereau, Alain (author)
Wang, Sophia S. (author)
Kelly, Rachel S. (author)
Lan, Qing (author)
Teras, Lauren R. (author)
Chatterjee, Nilanjan (author)
Chung, Charles C. (author)
Yeager, Meredith (author)
Brooks-Wilson, Angela R. (author)
Hartge, Patricia (author)
Purdue, Mark P. (author)
Birmann, Brenda M. (author)
Armstrong, Bruce K. (author)
Cocco, Pierluigi (author)
Zhang, Yawei (author)
Severi, Gianluca (author)
Zeleniuch-Jacquotte, Anne (author)
Lawrence, Charles (author)
Burdette, Laurie (author)
Yuenger, Jeffrey (author)
Hutchinson, Amy (author)
Jacobs, Kevin B. (author)
Call, Timothy G. (author)
Shanafelt, Tait D. (author)
Novak, Anne J. (author)
Kay, Neil E. (author)
Liebow, Mark (author)
Wang, Alice H. (author)
Smedby, Karin E. (author)
Karolinska Institutet
Adami, Hans-Olov (author)
Karolinska Institutet
Melbye, Mads (author)
Glimelius, Bengt (author)
Uppsala universitet,Enheten för onkologi
Chang, Ellen T. (author)
Glenn, Martha (author)
Curtin, Karen (author)
Cannon-Albright, Lisa A. (author)
Jones, Brandt (author)
Diver, W. Ryan (author)
Link, Brian K. (author)
Weiner, George J. (author)
Conde, Lucia (author)
Bracci, Paige M. (author)
Riby, Jacques (author)
Holly, Elizabeth A. (author)
Smith, Martyn T. (author)
Jackson, Rebecca D. (author)
Tinker, Lesley F. (author)
Benavente, Yolanda (author)
Becker, Nikolaus (author)
Boffetta, Paolo (author)
Brennan, Paul (author)
Foretova, Lenka (author)
Maynadie, Marc (author)
McKay, James (author)
Staines, Anthony (author)
Rabe, Kari G. (author)
Achenbach, Sara J. (author)
Vachon, Celine M. (author)
Goldin, Lynn R. (author)
Strom, Sara S. (author)
Lanasa, Mark C. (author)
Spector, Logan G. (author)
Leis, Jose F. (author)
Cunningham, Julie M. (author)
Weinberg, J. Brice (author)
Morrison, Vicki A. (author)
Caporaso, Neil E. (author)
Norman, Aaron D. (author)
Linet, Martha S. (author)
De Roos, Anneclaire J. (author)
Morton, Lindsay M. (author)
Severson, Richard K. (author)
Riboli, Elio (author)
Vineis, Paolo (author)
Kaaks, Rudolph (author)
Trichopoulos, Dimitrios (author)
Masala, Giovanna (author)
Weiderpass, Elisabete (author)
Karolinska Institutet
Chirlaque, Mara-Dolores (author)
Vermeulen, Roel C. H. (author)
Travis, Ruth C. (author)
Giles, Graham G. (author)
Albanes, Demetrius (author)
Virtamo, Jarmo (author)
Weinstein, Stephanie (author)
Clavel, Jacqueline (author)
Zheng, Tongzhang (author)
Holford, Theodore R. (author)
Offit, Kenneth (author)
Zelenetz, Andrew (author)
Klein, Robert J. (author)
Spinelli, John J. (author)
Bertrand, Kimberly A. (author)
Laden, Francine (author)
Giovannucci, Edward (author)
Kraft, Peter (author)
Kricker, Anne (author)
Turner, Jenny (author)
Vajdic, Claire M. (author)
Ennas, Maria Grazia (author)
Ferri, Giovanni M. (author)
Miligi, Lucia (author)
Liang, Liming (author)
Sampson, Joshua (author)
Crouch, Simon (author)
Park, Ju-Hyun (author)
North, Kari E. (author)
Cox, Angela (author)
Snowden, John A. (author)
Wright, Josh (author)
Carracedo, Angel (author)
Lopez-Otin, Carlos (author)
Bea, Silvia (author)
Salaverria, Itziar (author)
Martin-Garcia, David (author)
Campo, Elias (author)
Fraumeni, Joseph F., Jr. (author)
de Sanjose, Silvia (author)
Hjalgrim, Henrik (author)
Cerhan, James R. (author)
Chanock, Stephen J. (author)
Rothman, Nathaniel (author)
Slager, Susan L. (author)
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 (creator_code:org_t)
2013-06-16
2013
English.
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:8, s. 868-U202
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Genome-wide association studies (GWAS) have previously identified 13 loci associated with risk of chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL). To identify additional CLL susceptibility loci, we conducted the largest meta-analysis for CLL thus far, including four GWAS with a total of 3,100 individuals with CLL (cases) and 7,667 controls. In the meta-analysis, we identified ten independent associated SNPs in nine new loci at 10q23.31 (ACTA2 or FAS (ACTA2/FAS), P = 1.22 x 10(-14)), 18q21.33 (BCL2, P = 7.76 x 10(-11)), 11p15.5 (C11orf21, P = 2.15 x 10(-10)), 4q25 (LEF1, P = 4.24 x 10(-10)), 2q33.1 (CASP10 or CASP8 (CASP10/CASP8), P = 2.50 x 10(-9)), 9p21.3 (CDKN2B-AS1, P = 1.27 x 10(-8)), 18q21.32 (PMAIP1, P = 2.51 x 10(-8)), 15q15.1 (BMF, P = 2.71 x 10(-10)) and 2p22.2 (QPCT, P = 1.68 x 10(-8)), as well as an independent signal at an established locus (2q13, ACOXL, P = 2.08 x 10(-18)). We also found evidence for two additional promising loci below genome-wide significance at 8q22.3 (ODF1, P = 5.40 x 10(-8)) and 5p15.33 (TERT, P = 1.92 x 10(-7)). Although further studies are required, the proximity of several of these loci to genes involved in apoptosis suggests a plausible underlying biological mechanism.

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By the author/editor
Berndt, Sonja I.
Skibola, Christi ...
Joseph, Vijai
Camp, Nicola J.
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Hartge, Patricia
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Wang, Alice H.
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Curtin, Karen
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Boffetta, Paolo
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Maynadie, Marc
McKay, James
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Vachon, Celine M ...
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Trichopoulos, Di ...
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Travis, Ruth C.
Giles, Graham G.
Albanes, Demetri ...
Virtamo, Jarmo
Weinstein, Steph ...
Clavel, Jacqueli ...
Zheng, Tongzhang
Holford, Theodor ...
Offit, Kenneth
Zelenetz, Andrew
Klein, Robert J.
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Bertrand, Kimber ...
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Giovannucci, Edw ...
Kraft, Peter
Kricker, Anne
Turner, Jenny
Vajdic, Claire M ...
Ennas, Maria Gra ...
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Miligi, Lucia
Liang, Liming
Sampson, Joshua
Crouch, Simon
Park, Ju-Hyun
North, Kari E.
Cox, Angela
Snowden, John A.
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Bea, Silvia
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Articles in the publication
Nature Genetics
By the university
Uppsala University
Karolinska Institutet

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