| 1. |
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| 2. |
- Klionsky, Daniel J., et al.
(författare)
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Guidelines for the use and interpretation of assays for monitoring autophagy
- 2012
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Ingår i: Autophagy. - : Informa UK Limited. - 1554-8635 .- 1554-8627. ; 8:4, s. 445-544
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Forskningsöversikt (refereegranskat)abstract
- In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
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| 3. |
- Aguilar, J., et al.
(författare)
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Decoherence in neutrino oscillation at the ESSnuSB experiment
- 2024
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Ingår i: Journal of High Energy Physics (JHEP). - : Springer Nature. - 1126-6708 .- 1029-8479. ; 2024:8
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Tidskriftsartikel (refereegranskat)abstract
- Neutrino oscillation experiments provide a unique window in exploring several new physics scenarios beyond the standard three flavour. One such scenario is quantum decoherence in neutrino oscillation which tends to destroy the interference pattern of neutrinos reaching the far detector from the source. In this work, we study the decoherence in neutrino oscillation in the context of the ESSnuSB experiment. We consider the energy-independent decoherence parameter and derive the analytical expressions for Pμe and Pμμ probabilities in vacuum. We have computed the capability of ESSnuSB to put bounds on the decoherence parameters namely, Γ21 and Γ32 and found that the constraints on Γ21 are competitive compared to the DUNE bounds and better than the most stringent LBL ones from MINOS/MINOS+. We have also investigated the impact of decoherence on the ESSnuSB measurement of the Dirac CP phase δCP and concluded that it remains robust in the presence of new physics.
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| 4. |
- Aguilar, J., et al.
(författare)
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Search for Leptonic CP Violation with the ESSnuSBplus Project
- 2024
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Ingår i: Letters in High Energy Physics. - : Andromeda Publishing And Academic Services LTD. - 2632-2714.
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Tidskriftsartikel (refereegranskat)abstract
- ESSνSB is a design study for a next-generation long-baseline neutrino experiment that aims at the precise measurement of the CP-violating phase, δCP, in the leptonic sector at the second oscillation maximum. The conceptual design report published from the first phase of the project showed that after 10 years of data taking, more than 70% of the possible δCP range will be covered with 5σ C.L. to reject the no-CP-violation hypothesis. The expected value of δCP precision is smaller than 8◦ for all δCP values. The next phase of the project, the ESSνSB+, aims at using the intense muon flux produced together with neutrinos to measure the neutrino-nucleus cross-section, the dominant term of the systematic uncertainty, in the energy range of 0.2–0.6 GeV, using a Low Energy neutrinos from STORed Muons (LEnuSTORM) and a Low Energy Monitored Neutrino Beam (LEMNB) facilities.
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| 5. |
- Aguilar, J., et al.
(författare)
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Study of nonstandard interactions mediated by a scalar field at the ESSnuSB experiment
- 2024
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Ingår i: Physical Review D. - : American Physical Society. - 2470-0010 .- 2470-0029. ; 109:11
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, we study scalar mediator induced nonstandard interactions (SNSIs) in the context of the ESSnuSB experiment. In particular, we study the capability of ESSnuSB to put bounds on the SNSI parameters and also study the impact of SNSIs in the measurement of the leptonic CP phase δCP. Existence of SNSIs modifies the neutrino mass matrix and this modification can be expressed in terms of three diagonal real parameters (ηee, ημμ, and ηττ) and three off-diagonal complex parameters (ηeμ, ηeτ, and ημτ). Our study shows that the upper bounds on the parameters ημμ and ηττ depend upon how Δm312 is minimized in the theory. However, this is not the case when one tries to measure the impact of SNSIs on δCP. Further, we show that the CP sensitivity of ESSnuSB can be completely lost for certain values of ηee and ημτ for which the appearance channel probability becomes independent of δCP.
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| 6. |
- Burgman, A., et al.
(författare)
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The ESSnuSB Design Study: Overview and Future Prospects
- 2023
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Ingår i: Universe. - : MDPI. - 2218-1997. ; 9:8
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Forskningsöversikt (refereegranskat)abstract
- ESSnuSB is a design study for an experiment to measure the CP violation in the leptonic sector at the second neutrino oscillation maximum using a neutrino beam driven by the uniquely powerful ESS linear accelerator. The reduced impact of systematic errors on sensitivity at the second maximum allows for a very precise measurement of the CP violating parameter. This review describes the fundamental advantages of measurement at the second maximum, the necessary upgrades to the ESS linac in order to produce a neutrino beam, the near and far detector complexes, and the expected physics reach of the proposed ESSnuSB experiment, concluding with the near future developments aimed at the project realization.
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| 7. |
- Aguilar, J., et al.
(författare)
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Study of nonstandard interactions mediated by a scalar field at the ESSnuSB experiment
- 2024
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Ingår i: Physical Review D. - : American Physical Society (APS). - 2470-0010 .- 2470-0029. ; 109:11
-
Tidskriftsartikel (refereegranskat)abstract
- In this paper, we study scalar mediator induced nonstandard interactions (SNSIs) in the context of the ESSnuSB experiment. In particular, we study the capability of ESSnuSB to put bounds on the SNSI parameters and also study the impact of SNSIs in the measurement of the leptonic ?? phase ???. Existence of SNSIs modifies the neutrino mass matrix and this modification can be expressed in terms of three diagonal real parameters (???, ???, and ???) and three off-diagonal complex parameters (???, ???, and ???). Our study shows that the upper bounds on the parameters ??? and ??? depend upon how Δ?231 is minimized in the theory. However, this is not the case when one tries to measure the impact of SNSIs on ???. Further, we show that the ?? sensitivity of ESSnuSB can be completely lost for certain values of ??? and ??? for which the appearance channel probability becomes independent of ???.
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| 8. |
- Blennow, Mattias, 1980-, et al.
(författare)
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A combined study of source, detector and matter non-standard neutrino interactions at DUNE
- 2016
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Ingår i: Journal of High Energy Physics (JHEP). - : Springer. - 1126-6708 .- 1029-8479. ; 2016:8
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Tidskriftsartikel (refereegranskat)abstract
- We simultaneously investigate source, detector and matter non-standard neutrino interactions at the proposed DUNE experiment. Our analysis is performed using a Markov Chain Monte Carlo exploring the full parameter space. We find that the sensitivity of DUNE to the standard oscillation parameters is worsened due to the presence of non-standard neutrino interactions. In particular, there are degenerate solutions in the leptonic mixing angle θ23 and the Dirac CP-violating phase δ. We also compute the expected sensitivities at DUNE to the non-standard interaction parameters. We find that the sensitivities to the matter non-standard interaction parameters are substantially stronger than the current bounds (up to a factor of about 15). Furthermore, we discuss correlations between the source/detector and matter non-standard interaction parameters and find a degenerate solution in θ23. Finally, we explore the effect of statistics on our results.
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| 9. |
- Choubey, S., et al.
(författare)
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Constraints on sterile neutrino oscillations using DUNE near detector
- 2017
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Ingår i: Physics Letters B. - : Elsevier. - 0370-2693 .- 1873-2445. ; 764, s. 135-141
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Tidskriftsartikel (refereegranskat)abstract
- DUNE (Deep Underground Neutrino Experiment) is a proposed long-baseline neutrino experiment in the US with a baseline of 1300 km from Fermi National Accelerator Laboratory (Fermilab) to Sanford Underground Research Facility, which will house a 40 kt Liquid Argon Time Projection Chamber (LArTPC) as the far detector. The experiment will also have a fine grained near detector for accurately measuring the initial fluxes. We show that the energy range of the fluxes and baseline of the DUNE near detector is conducive for observing νμ→νe oscillations of Δm2∼ eV2 scale sterile neutrinos, and hence can be effectively used for testing to very high accuracy the reported oscillation signal seen by the LSND and MiniBooNE experiments. We study the sensitivity of the DUNE near detector to sterile neutrino oscillations by varying the baseline, detector fiducial mass and systematic uncertainties. We find that the detector mass and baseline of the currently proposed near detector at DUNE will be able to test the entire LSND parameter region with good precision. The dependence of sensitivity on baseline and detector mass is seen to give interesting results, while dependence on systematic uncertainties is seen to be small.
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| 10. |
- Choubey, Sandhya, et al.
(författare)
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Indirect searches for dark matter signatures at ino
- 2020
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Ingår i: Journal of Physics. - : IOP Publishing.
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Konferensbidrag (refereegranskat)abstract
- Neutrino fluxes could arise due to annihilation of Weakly Interactive Massive Particles (WIMPs) in the center of the sun. We study the prospects of search for muon events due to such neutrinos at the upcoming Iron CALorimeter (ICAL) detector to be housed at India-based Neutrino Observatory (INO). Although the atmospheric neutrinos will pose a serious background to the signal neutrinos produced through WIMP annihilation, the former could be supressed significantly by using the directional property of signal neutrinos. For 50kt×10 years of ICAL running and WIMP masses (mχ ) between 3-100 GeV, we perform a χ2 analysis and present expected exclusion regions in the σβ-mx and σβι-mx plane, where σβ and σβι are the WIMP-nucleon Spin-Dependent (SD) and Spin-Independent (SI) scattering cross-sections, respectively. For mx = 25 GeV, the expected 90 % C.L. exclusion limit on σβ are σβ < 7.82 x 10-41 cm2 for τ+τ- channel and σβ < 1.23 10-39 cm2 for 66 channel. For same m×, the expected 90 % C.L. exclusion limits on σβι are σβι < 8.97 × 10-43 cm2 for τ +τ - channel and σβι < 1.43×10-41 cm2 for 66 channel.
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