| 1. |
- Kehoe, Laura, et al.
(författare)
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Make EU trade with Brazil sustainable
- 2019
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341-
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 2. |
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| 3. |
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| 4. |
- Bergamaschi, Peter, et al.
(författare)
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European Obspack compilation of atmospheric carbon dioxide data from ICOS and non-ICOS European stations for the period 1972-2023; : obspack_co2_466_GLOBALVIEWplus_v8.0_2023-04-26
- 2023
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- This data package contains high accuracy CO2 dry air mole fractions from 58 ICOS and non-ICOS European observatories at in total 132 observation levels, collected by the ICOS Atmosphere Thematic Centre (ATC) and provided by the station contributors. The package is part of the Globalviewplus v8.0 data product, released in 2022 and is intended for use in carbon cycle inverse modeling, model evaluation, and satellite validation studies. Please report errors and send comments regarding this product to the ObsPack originators. Please read carefully the ObsPack Fair Use statement and cite appropriately. This is the sixth release of the GLOBALVIEWplus (GV+) cooperative data product. Please review the release notes for this product at www.esrl.noaa.gov/gmd/ccgg/obspack/release_notes.html. Metadata for this product are available at https://commons.datacite.org/doi.org/10.18160/CEC4-CAGK. Please visit http://www.gml.noaa.gov/ccgg/obspack/ for more information.
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| 5. |
- Flener, Pierre, et al.
(författare)
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Constraint Programming in Sweden
- 2009
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Ingår i: IEEE Intelligent Systems. - : IEEE Press. - 1541-1672. ; 24:2, s. 87-89
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Forskningsöversikt (övrigt vetenskapligt/konstnärligt)
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| 6. |
- Glaa, Besma, 1978-
(författare)
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Contribution à la conception et l'optimisation d'un système d'aide à la gestion des urgences
- 2009
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- La prise en charge des urgences est l'une des missions principales des établissements de santé. Ces derniers, au travers de la structure d'urgence, ont du depuis les années 90, répondre à une demande exponentielle de soins non programmés, ce qui a posé le problème du dimensionnement de la structure et de ses moyens. Cette situation a provoqué des problèmes organisationels énormes. Face à cette situation, les décideurs hospitaliers manquent d'outils qui sont indispensables pour redimensionner les ressources humaines et matérielles et pour planifier la prise en charge des urgences. En réponse à ces besoins, cette thèse propose une démarche d'aide à la gestion des systèmes de prise en charge des urgences. Cette démarche aborde trois principaux problèmes. Dans un premier temps, nous nous focalisons sur la modélisation des processus de prise en charge des urgences et ses principales filières. Cette modélisation, couplée à la simulation de flux, nous permettra d'analyser le fonctionnement de la structure et de déterminer les paramètres influents la prise en charge des urgences. Nous nous intéressons, dans un second temps, à l'affectation des personnels infirmiers en tenant compte de leur profil de compétence à l'aide de la programmation linéaire. Enfin, nous étudierons le problème de prise en charge des urgences vitales intrahospitalières. A l'aide d'une modélisation réunie avec une simulation, nous procédons à une démarche de conception et d'évaluation de la chaine de survie intrahospitalière. Nous abordons, dans cette dernière étape, la question de d'affectation de l'équipe mobile de réanimation d'urgence ainsi que …
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| 7. |
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| 8. |
- Herrera-Rivero, Marisol, et al.
(författare)
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Exploring the genetics of lithium response in bipolar disorders.
- 2023
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Ingår i: Research square.
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Lithium (Li) remains the treatment of choice for bipolar disorders (BP). Its mood-stabilizing effects help reduce the long-term burden of mania, depression and suicide risk in patients with BP. It also has been shown to have beneficial effects on disease-associated conditions, including sleep and cardiovascular disorders. However, the individual responses to Li treatment vary within and between diagnostic subtypes of BP (e.g. BP-I and BP-II) according to the clinical presentation. Moreover, long-term Li treatment has been linked to adverse side-effects that are a cause of concern and non-adherence, including the risk of developing chronic medical conditions such as thyroid and renal disease. In recent years, studies by the Consortium on Lithium Genetics (ConLiGen) have uncovered a number of genetic factors that contribute to the variability in Li treatment response in patients with BP. Here, we leveraged the ConLiGen cohort (N=2,064) to investigate the genetic basis of Li effects in BP. For this, we studied how Li response and linked genes associate with the psychiatric symptoms and polygenic load for medical comorbidities, placing particular emphasis on identifying differences between BP-I and BP-II.We found that clinical response to Li treatment, measured with the Alda scale, was associated with a diminished burden of mania, depression, substance and alcohol abuse, psychosis and suicidal ideation in patients with BP-I and, in patients with BP-II, of depression only. Our genetic analyses showed that a stronger clinical response to Li was modestly related to lower polygenic load for diabetes and hypertension in BP-I but not BP-II. Moreover, our results suggested that a number of genes that have been previously linked to Li response variability in BP differentially relate to the psychiatric symptomatology, particularly to the numbers of manic and depressive episodes, and to the polygenic load for comorbid conditions, including diabetes, hypertension and hypothyroidism.Taken together, our findings suggest that the effects of Li on symptomatology and comorbidity in BP are partially modulated by common genetic factors, with differential effects between BP-I and BP-II.
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| 9. |
- Herrera-Rivero, Marisol, et al.
(författare)
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Immunogenetics of lithium response and psychiatric phenotypes in patients with bipolar disorder.
- 2023
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Ingår i: Research square.
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- The link between bipolar disorder (BP) and immune dysfunction remains controversial. While epidemiological studies have long suggested an association, recent research has found only limited evidence of such a relationship. To clarify this, we investigated the contributions of immune-relevant genetic factors to the response to lithium (Li) treatment and the clinical presentation of BP. First, we assessed the association of a large collection of immune-related genes (4,925) with Li response, defined by the Retrospective Assessment of the Lithium Response Phenotype Scale (Alda scale), and clinical characteristics in patients with BP from the International Consortium on Lithium Genetics (ConLi+Gen, N = 2,374). Second, we calculated here previously published polygenic scores (PGSs) for immune-related traits and evaluated their associations with Li response and clinical features. We found several genes associated with Li response at p < 1×10- 4 values, including HAS3, CNTNAP5 and NFIB. Network and functional enrichment analyses uncovered an overrepresentation of pathways involved in cell adhesion and intercellular communication, which appear to converge on the well-known Li-induced inhibition of GSK-3β. We also found various genes associated with BP's age-at-onset, number of mood episodes, and presence of psychosis, substance abuse and/or suicidal ideation at the exploratory threshold. These included RTN4, XKR4, NRXN1, NRG1/3 and GRK5. Additionally, PGS analyses suggested serum FAS, ECP, TRANCE and cytokine ligands, amongst others, might represent potential circulating biomarkers of Li response and clinical presentation. Taken together, our results support the notion of a relatively weak association between immunity and clinically relevant features of BP at the genetic level.
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| 10. |
- Izquierdo Riera, Francisco Blas, 1988, et al.
(författare)
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Methods for securely offloading password hashing to client
- 2022
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- After a successful compromise, attackers may recover stored password hashes. These hashes may then be cracked to be able to use them on other services where the same or similar passwords may have been reused. A common method to secure such hashes is by using computationally expensive hash functions. This is usually done on the server and consumes a large amount of resources. Moreover, no such techniques exist for storing credentials on the client so that only the desired server can recover them. This invention aims to solve the issue of storing password hashes primarily in two ways: • moving the password hashing step to the client without introducing new security risks in the process; and • encrypting client stored hashes in a way that only the targeted server is able to recover them.
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