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Träfflista för sökning "WFRF:(Climent F) "

Sökning: WFRF:(Climent F)

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  • Zaborowski, AM, et al. (författare)
  • Microsatellite instability in young patients with rectal cancer: molecular findings and treatment response
  • 2022
  • Ingår i: The British journal of surgery. - : Oxford University Press (OUP). - 1365-2168 .- 0007-1323. ; 109:3, s. 251-255
  • Tidskriftsartikel (refereegranskat)abstract
    • In this study of 400 patients with early-onset rectal cancer, 12.5 per cent demonstrated microsatellite instability (MSI). MSI was associated with a reduced likelihood of nodal positivity, an increased rate of pathological complete response, and improved disease-specific survival.
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  • Luen, S J, et al. (författare)
  • Genomic characterisation of hormone receptor-positive breast cancer arising in very young women.
  • 2023
  • Ingår i: Annals of oncology : official journal of the European Society for Medical Oncology. - : Elsevier BV. - 1569-8041. ; 34:4, s. 397-409
  • Tidskriftsartikel (refereegranskat)abstract
    • Very young premenopausal women diagnosed with hormone receptor-positive, HER2-negative (HR+HER2-) early breast cancer (EBC) have higher rates of recurrence and death for reasons that remain largely unexplained.Genomic sequencing was applied to HR+HER2- tumours from patients enrolled in the SOFT clinical trial to determine genomic drivers that are enriched in young premenopausal women. Genomic alterations were characterised using next-generation sequencing from a subset of 1,276 patients (deep targeted sequencing, N=1258; whole-exome sequencing in a young-age, case-control subsample, N=82). We defined copy number (CN) subgroups and assessed for features suggestive of homologous recombination deficiency (HRD). Genomic alteration frequencies were compared between young premenopausal women (<40 years) and older premenopausal women (≥40 years), and assessed for associations with distant recurrence-free interval (DRFI), and overall survival (OS).Younger women (<40 years, N=359) compared with older women (≥40 years, N=917) had significantly higher frequencies of mutations in GATA3 (19%vs16%) and CN-amplifications (47%vs26%), but significantly lower frequencies of mutations in PIK3CA (32%vs47%), CDH1 (3%vs9%), and MAP3K1 (7%vs12%). Additionally, significantly higher frequencies of features suggestive of HRD (27%vs21%), and a higher proportion of PIK3CA mutations with concurrent CN-amplifications (23%vs11%).Genomic features suggestive of HRD, PIK3CA mutations with CN-amplifications, and CN-amplifications associated with significantly worse DRFI and OS compared with those without these features. These poor prognostic features were enriched in younger patients: present in 72% of patients aged <35 years, 54% aged 35-39 years, and 40% ≥40 years. Poor prognostic features (N=584[46%]) vs none (N=692[54%]) had an 8-year DRFI of 84%vs94% and OS of 88%vs96%. Younger women (<40) had the poorest outcomes: 8-year DRFI 74%vs85% and OS of 80%vs93% respectively.These results provide insights into genomic alterations that are enriched in young women with HR+HER2-EBC, provide rationale for genomic subgrouping, and highlight priority molecular targets for future clinical trials.
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  • Schneider, P. A., et al. (författare)
  • The dependence of confinement on the isotope mass in the core and the edge of AUG and JET-ILW H-mode plasmas
  • 2022
  • Ingår i: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 62:2
  • Tidskriftsartikel (refereegranskat)abstract
    • Experiments in ASDEX Upgrade (AUG) and JET with the ITER-like wall (JET-ILW) are performed to separate the pedestal and core contributions to confinement in H-modes with different main ion masses. A strong isotope mass dependence in the pedestal is found which is enhanced at high gas puffing. This is because the ELM type changes when going from D to H for matched engineering parameters, which is likely due to differences in the inter ELM transport with isotope mass. The pedestal can be matched in H and D plasmas by varying only the triangularity and keeping the engineering parameters relevant for core transport the same. With matched pedestals Astra/TGLF (Sat1geo) core transport simulations predict the experimental profiles equally well for H and D. These core transport simulations show a negligible mass dependence and no gyro-Bohm scaling is observed. However, to match the experimental observations at medium beta it is required to take the fast-ion dilution and rotation into account. This is not enough for high beta plasmas where for the first time a profile match between H and D plasmas was achieved experimentally. Under these conditions quasilinear modelling with TGLF over predicts the transport in the core of H and D plasmas alike.
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  • Climent, J. B., et al. (författare)
  • VLTI-PIONIER imaging of the red supergiant V602 Carinae
  • 2020
  • Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 635
  • Tidskriftsartikel (refereegranskat)abstract
    • Context. Red supergiant stars possess surface features and extended molecular atmospheres. Photospheric convection may be a crucial factor of the levitation of the outer atmospheric layers. However, the mechanism responsible is still poorly understood.Aims. We image the stellar surface of V602 Carinae (V602 Car) to constrain the morphology and contrast of the surface features and of the extended atmospheric layers.Methods. We observed V602 Car with the Very Large Telescope Interferometer PIONIER instrument (1.53-1.78 mu m) between May and July 2016, and April and July 2019 with different telescope configurations. We compared the image reconstructions with 81 temporal snapshots of 3D radiative-hydrodynamics (RHD) (COBOLD)-B-5 simulations in terms of contrast and morphology, using the Structural Similarity Index.Results. The interferometric data are compatible with an overall spherical disk of angular diameter 4.4 0.2 mas, and an extended molecular layer. In 2016, the reconstructed image reveals a bright arc-like feature toward the northern rim of the photospheric surface. In 2019, an arc-like feature is seen at a different orientation and a new peak of emission is detected on the opposite side. The contrasts of the reconstructed surface images are 11% +/- 2% and 9% +/- 2% for 2016 and 2019, respectively. The morphology and contrast of the two images are consistent with 3D RHD simulations, within our achieved spatial resolution and dynamic range. The extended molecular layer contributes 10-13% of the total flux with an angular diameter of 6-8 mas. It is present but not clearly visible in the reconstructed images because it is close to the limits of the achieved dynamic range. The presence of the molecular layer is not reproduced by the 3D RHD simulations.Conclusions. 3D RHD simulations predict substructures similar to the observed surface features of V602 Car at two different epochs. We interpret the structure on the stellar surface as being related to instationary convection. This structure is further convolved to larger observed patches on the stellar surface with our observational spatial resolution. Even though the simulations reproduce the observed features on the stellar surface, convection alone may not be the only relevant process that is levitating the atmosphere.
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  • Gómez-Climent, M. Á, et al. (författare)
  • Olfactory bulbectomy, but not odor conditioned aversion, induces the differentiation of immature neurons in the adult rat piriform cortex
  • 2011
  • Ingår i: Neuroscience. - : Elsevier. - 0306-4522 .- 1873-7544. ; 181:5, s. 18-27
  • Tidskriftsartikel (refereegranskat)abstract
    • The piriform cortex layer II of young-adult rats presents a population of prenatally generated cells, which express immature neuronal markers, such as the polysialylated form of the neural cell adhesion molecule (PSA-NCAM) or doublecortin (DCX), and display structural characteristics of immature neurons. The number of PSA-NCAM/DCX expressing cells in this region decreases markedly as age progresses, suggesting that these cells differentiate or die. Since the piriform cortex receives a major input from the olfactory bulb and participates in olfactory information processing, it is possible that the immature neurons in layer II are affected by manipulations of the olfactory bulb or olfactory learning. It is not known whether these cells can be induced to differentiate and, if so, what would be their fate. In order to address these questions, we have performed unilateral olfactory bulbectomy (OBX) and an olfactory learning paradigm (taste-potentiated odor aversion, TPOA), in young-adult rats and have studied the expression of different mature and immature neuronal markers, as well as the presence of cell death. We have found that 14 h after OBX there was a dramatic decrease in the number of both PSA-NCAM and DCX expressing cells in piriform cortex layer II, whereas that of cells expressing NeuN, a mature neuronal marker, increased. By contrast, the number of cells expressing glutamate decarboxylase, isoform 67 (GAD67), a marker for interneurons, decreased slightly. Additionally, we have not found evidence of numbers of dying cells high enough to justify the disappearance of immature neurons. Analysis of animals subjected to TPOA revealed that this paradigm does not affect PSA-NCAM expressing cells. Our results strongly suggest that OBX can induce the maturation of immature neurons in the piriform cortex layer II and that these cells do not become interneurons. By contrast, these cells do not seem to play a crucial role in olfactory memory.
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