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Träfflista för sökning "WFRF:(Cloninger C. Robert) "

Sökning: WFRF:(Cloninger C. Robert)

  • Resultat 1-10 av 44
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1.
  • Huckins, Laura M., et al. (författare)
  • Gene expression imputation across multiple brain regions provides insights into schizophrenia risk
  • 2019
  • Ingår i: Nature genetics. - 1546-1718. ; 51:4, s. 659-
  • Tidskriftsartikel (refereegranskat)abstract
    • Transcriptomic imputation approaches combine eQTL reference panels with large-scale genotype data in order to test associations between disease and gene expression. These genic associations could elucidate signals in complex genome-wide association study (GWAS) loci and may disentangle the role of different tissues in disease development. We used the largest eQTL reference panel for the dorso-lateral prefrontal cortex (DLPFC) to create a set of gene expression predictors and demonstrate their utility. We applied DLPFC and 12 GTEx-brain predictors to 40,299 schizophrenia cases and 65,264 matched controls for a large transcriptomic imputation study of schizophrenia. We identified 413 genic associations across 13 brain regions. Stepwise conditioning identified 67 non-MHC genes, of which 14 did not fall within previous GWAS loci. We identified 36 significantly enriched pathways, including hexosaminidase-A deficiency, and multiple porphyric disorder pathways. We investigated developmental expression patterns among the 67 non-MHC genes and identified specific groups of pre- and postnatal expression.
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2.
  • Ripke, Stephan, et al. (författare)
  • Biological insights from 108 schizophrenia-associated genetic loci
  • 2014
  • Ingår i: Nature. - 0028-0836. ; 511:7510, s. 421-427
  • Tidskriftsartikel (refereegranskat)abstract
    • Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and 113,075 controls. We identify 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported. Associations were enriched among genes expressed in brain, providing biological plausibility for the findings. Many findings have the potential to provide entirely new insights into aetiology, but associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Independent of genes expressed in brain, associations were enriched among genes expressed in tissues that have important roles in immunity, providing support for the speculated link between the immune system and schizophrenia.
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3.
  • Marshall, Christian R., et al. (författare)
  • Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects
  • 2017
  • Ingår i: Nature Genetics. - 1061-4036. ; 49:1, s. 27-35
  • Tidskriftsartikel (refereegranskat)abstract
    • Copy number variants (CNVs) have been strongly implicated in the genetic etiology of schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk has been hampered by limited sample sizes. We sought to address this obstacle by applying a centralized analysis pipeline to a SCZ cohort of 21,094 cases and 20,227 controls. A global enrichment of CNV burden was observed in cases (odds ratio (OR) = 1.11, P = 5.7 x 10(-15)), which persisted after excluding loci implicated in previous studies (OR = 1.07, P = 1.7 x 10(-6)). CNV burden was enriched for genes associated with synaptic function (OR = 1.68, P = 2.8 x 10(-11)) and neurobehavioral phenotypes in mouse (OR = 1.18, P = 7.3 x 10(-5)). Genome-wide significant evidence was obtained for eight loci, including 1q21.1, 2p16.3 (NRXN1), 3q29, 7q11.2, 15q13.3, distal 16p11.2, proximal 16p11.2 and 22q11.2. Suggestive support was found for eight additional candidate susceptibility and protective loci, which consisted predominantly of CNVs mediated by nonallelic homologous recombination.
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4.
  • Lee, S. Hong, et al. (författare)
  • Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
  • 2013
  • Ingår i: Nature genetics. - 1546-1718. ; 45:9, s. 984-
  • Tidskriftsartikel (refereegranskat)abstract
    • Most psychiatric disorders are moderately to highly heritable. The degree to which genetic variation is unique to individual disorders or shared across disorders is unclear. To examine shared genetic etiology, we use genome-wide genotype data from the Psychiatric Genomics Consortium (PGC) for cases and controls in schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD). We apply univariate and bivariate methods for the estimation of genetic variation within and covariation between disorders. SNPs explained 17-29% of the variance in liability. The genetic correlation calculated using common SNPs was high between schizophrenia and bipolar disorder (0.68 ± 0.04 s.e.), moderate between schizophrenia and major depressive disorder (0.43 ± 0.06 s.e.), bipolar disorder and major depressive disorder (0.47 ± 0.06 s.e.), and ADHD and major depressive disorder (0.32 ± 0.07 s.e.), low between schizophrenia and ASD (0.16 ± 0.06 s.e.) and non-significant for other pairs of disorders as well as between psychiatric disorders and the negative control of Crohn's disease. This empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders. © 2013 Nature America, Inc. All rights reserved.
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5.
  • Garcia, Danilo, et al. (författare)
  • Agentic, communal, and spiritual traits are related to the semantic representation of written narratives of positive and negative life events
  • 2015
  • Ingår i: Psychology of Well-Being. - 2211-1522. ; 5:8, s. 1-20
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: We used a computational method to quantitatively investigate the relationship between personality and written narratives of life events. Agentic (i.e., self- directedness), communal (i.e., cooperativeness), and spiritual (self-transcendence) traits were of special interest because they represent individual differences in intentional val- ues and goals, in contrast to temperament traits, which describe individual differences in automatic responses to emotional stimuli. We also investigated which pronouns were most common in relation to personality constructs that were significantly related to the narratives. Methods: Personality was assessed among 79 adolescents at one point in time using the NEO Personality Inventory—Revised (NEO-PI-R) and the temperament and char- acter inventory (TCI). Six months later, adolescents were asked to write down the most positive or the most negative event that had happened to them in the last 3 months. Adolescents were explicitly instructed to answer the following questions within their narratives: What happened? Who were involved? Why do you think it happened? How did you feel when it happened? How do you think the involved persons felt? The descriptions were quantified using a computational method in which the latent semantic analysis algorithm generates a semantic representation of the narratives. Results: Only self-directedness, cooperativeness, and self-transcendence were related to the semantic representation of the narratives. Moreover, cooperativeness and self- transcendence were associated with less frequent usage of singular pronouns (e.g., me respectively mine). Conclusions: Agentic, communal, and spiritual traits are involved when adolescents describe positive and negative life experiences. Moreover, high levels of communal and spiritual traits are related to less self-focused narratives. Keywords: Agency, Big five, Communion, Latent semantic analysis, Life story, Semantic spaces, Pronouns, Temperament and character inventory
6.
  • Zwir, Igor, et al. (författare)
  • Three Genetic-Environmental Networks for Human Personality
  • 2019
  • Ingår i: Molecular Psychiatry. - 1359-4184 .- 1476-5578.
  • Tidskriftsartikel (refereegranskat)abstract
    • Phylogenetic, developmental, and brain-imaging studies suggest that human personality is the integrated expression of three major systems of learning and memory that regulate (1) associative conditioning, (2) intentionality, and (3) self-awareness. We have uncovered largely disjoint sets of genes regulating these dissociable learning processes in different clusters of people with (1) unregulated temperament profiles (i.e., associatively conditioned habits and emotional reactivity), (2) organized character profiles (i.e., intentional self-control of emotional conflicts and goals), and (3) creative character profiles (i.e., self-aware appraisal of values and theories), respectively. However, little is known about how these temperament and character components of personality are jointly organized and develop in an integrated manner. In three large independent genome-wide association studies from Finland, Germany, and Korea, we used a data-driven machine learning method to uncover joint phenotypic networks of temperament and character and also the genetic networks with which they are associated. We found three clusters of similar numbers of people with distinct combinations of temperament and character profiles. Their associated genetic and environmental networks were largely disjoint, and differentially related to distinct forms of learning and memory. Of the 972 genes that mapped to the three phenotypic networks, 72% were unique to a single network. The findings in the Finnish discovery sample were blindly and independently replicated in samples of Germans and Koreans. We conclude that temperament and character are integrated within three disjoint networks that regulate healthy longevity and dissociable systems of learning and memory by nearly disjoint sets of genetic and environmental influences.
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7.
  • Amato, Clara, et al. (författare)
  • Newly Graduated Nurses' Learning Work Climate, Health, Resilience, and Burnout Symptoms
  • 2020
  • Ingår i: 32nd Association for Psychological Science Annual Convention. Chicago, Illinois, USA.
  • Konferensbidrag (övrigt vetenskapligt)abstract
    • The results provide an indication of important learning work climate factors associated to newly graduated nurses’ health, ability to cope successfully in adverse circumstances (i.e., resilience), and burnout symptoms. It is, however, plausible that there is an interconnection between personal vulnerability, learning climate, and health (Stoyanov & Cloninger, 2011).
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8.
  • Cloninger, Kevin M., et al. (författare)
  • Increases in character development, resilience, and well-being among participants in Anthropedia's well-being coaching training
  • 2018
  • Ingår i: 30th APS Annual Convention. San Francisco, CA, USA: 24-27 May 2018.
  • Konferensbidrag (övrigt vetenskapligt)abstract
    • This study examined the impacts of the year-long, 270-hour, Anthropedia Well-Being Coaching Training on character development, health, and resilience. There was a significant increase in subjective well-being, and character development including self-acceptance, empathy, moral reasoning, and self-transcendence as a whole as measured by the Temperament and Character Inventory (TCI).
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9.
  • Cloninger, Kevin M., et al. (författare)
  • The Health Effects of Anthropedia’s Well-Being Coaching: A 6-Month Pilot Study Among Long-Term Unemployment Swedish Young Adults
  • 2019
  • Ingår i: 3rd Biennial International Convention of Psychological Science, Paris, France.
  • Konferensbidrag (övrigt vetenskapligt)abstract
    • In recent years Sweden had an increased number of asylum seekers entering the country. Asylum seeking can affect the physical and mental health of individuals due to prolonged application processes and waiting times which can lead to inactivity. Physical inactivity is one of the leading risk factors leading to noncommunicable diseases and overall mortality. The Public Health Report Blekinge 2014 states that groups with low socioeconomic status are less likely to be physically active in comparison with groups with a high socioeconomic status. Physical activity contributes to physical and mental well-being, and increases the possibilities for creating social networks as well as being part of the society. The project “Health for Everybody” (Hälsa för Alla) offers physical and cultural activities to approximately 300 refugees who have been granted asylum in the Blekinge region. The activities are conducted with the help of physical trainers, testing staff and community workers. In its current format each group of 20 to 30 refugees is offered training once a week for a 10-week period. The participants’ physical and psychological health and lifestyle habits are measured before and after the program through bioimpedance, physical conditioning tests and self-reports of psychological aspects related to health and lifestyle. We examined the health effects of cultural activities and Well-Being Coaching among long-term unemployed Swedish young adults. While individuals receiving cultural activities only showed a slight decrease in anxiety, those receiving Well-Being Coaching showed significant increases in subjective well-being and decreases in depression, anxiety, and sense of defeat and entrapment.
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10.
  • Cloninger, Kevin M., et al. (författare)
  • The Prevalence of Personality (Temperament and Character) Profiles among Swedish Newly Graduated Nurses
  • 2020
  • Ingår i: 32nd Association for Psychological Science Annual Convention. Chicago, Illinois, USA.
  • Konferensbidrag (övrigt vetenskapligt)abstract
    • Personal vulnerability (i.e., specific personality profiles) is a major factor for burnout among helping professionals. Compared to the general population, 80% of Swedish newly graduated nurses reported high Reward Dependence (i.e., being sentimental, warm, attached, and dependent) and 95% reported low Self-Directedness (i.e., being blaming, aimless, helpless, defensive, and unfulfilled).
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