SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Cordeiro Q) ;mspu:(article)"

Sökning: WFRF:(Cordeiro Q) > Tidskriftsartikel

  • Resultat 1-10 av 36
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Bertola, V, et al. (författare)
  • Association analysis between the C516T polymorphism in the 5-HT2A receptor gene and schizophrenia
  • 2007
  • Ingår i: Arquivos de neuro-psiquiatria. - : FapUNIFESP (SciELO). - 0004-282X. ; 65:1, s. 11-14
  • Tidskriftsartikel (refereegranskat)abstract
    • Data from epidemiological studies have demonstrated that genetics is an important risk factor for schizophrenia. Disturbances of serotonergic brain pathways have been implicated in the pathophysiology of schizophrenia. Some studies have suggested that the efficacy of atypical antipsychotics on schizophrenia treatment may be related to the serotonin 2A receptor (5-HT2A), and that serotonergic drugs may induce psychotic symptoms. Thus, the aim of this study was to investigate the association between the C516T polymorphism and schizophrenia in a Brazilian population composed by 246 patients and 315 healthy matched controls in a case-control approach. No statistically differences were observed in allelic (chi2=1.77, 1d.f., p=0.18) or genotypic (chi2=1.69, 2d.f., p=0.42) distributions between cases and controls. The results suggest that the C516T polymorphism of the 5-HT2A receptor gene is not related to the susceptibility for schizophrenia in our Brazilian sample.
  •  
2.
  •  
3.
  • Cappi, C, et al. (författare)
  • Association study between functional polymorphisms in the TNF-alpha gene and obsessive-compulsive disorder
  • 2012
  • Ingår i: Arquivos de neuro-psiquiatria. - : FapUNIFESP (SciELO). - 1678-4227 .- 0004-282X. ; 70:2, s. 87-90
  • Tidskriftsartikel (refereegranskat)abstract
    • Obsessive-compulsive disorder (OCD) is a prevalent psychiatric disorder of unknown etiology. However, there is some evidence that the immune system may play an important role in its pathogenesis. In the present study, two polymorphisms (rs1800795 and rs361525) in the promoter region of the cytokine tumor necrosis factor-alpha (TNFA) gene were genotyped in 183 OCD patients and in 249 healthy controls. The statistical tests were performed using the PLINK® software. We found that the A allele of the TNFA rs361525 polymorphism was significantly associated with OCD subjects, according to the allelic χ² association test (p=0.007). The presence of genetic markers, such as inflammatory cytokines genes linked to OCD, may represent additional evidence supporting the role of the immune system in its pathogenesis.
  •  
4.
  •  
5.
  •  
6.
  •  
7.
  •  
8.
  • Cordeiro, Q, et al. (författare)
  • Association between the SLC6A3 A1343G polymorphism and schizophrenia
  • 2010
  • Ingår i: Arquivos de neuro-psiquiatria. - : FapUNIFESP (SciELO). - 1678-4227 .- 0004-282X. ; 68:5, s. 716-719
  • Tidskriftsartikel (refereegranskat)abstract
    • Epidemiological studies have demonstrated that the genetic component is an important risk factor for the development of schizophrenia. The genes that codify the different compounds of the dopaminergic system have created interest for molecular investigations in patients with schizophrenia because the antipsychotic drugs, especially those of first generation, act on this cerebral system. Thus the aim of the present study was to investigate the possible association between a new single nucleotide polymorphism (rs6347) located in exon 9 of the protein transporter (SLC6A3) and schizophrenia. The distribution of the alleles and genotypes of the studied polymorphism was investigated in a sample of 235 patients and 834 controls matched by gender and age. There were statistical differences in the allelic (χ2=5.97, 1d.f. , p=0.01, OR=1.33-1.05<OR<1.69) and genotypic (χ2=6.56, 2d.f. , p=0.03) distributions between patients and controls. Thus the SLC6A3 A1343G polymorphism was associated to the SCZ phenotype in the investigated sample.
  •  
9.
  • Cordeiro, Q, et al. (författare)
  • Association study between the rs165599 catechol-O-methyltransferase genetic polymorphism and schizophrenia in a Brazilian sample
  • 2012
  • Ingår i: Arquivos de neuro-psiquiatria. - : FapUNIFESP (SciELO). - 1678-4227 .- 0004-282X. ; 70:12, s. 913-916
  • Tidskriftsartikel (refereegranskat)abstract
    • Schizophrenia is a severe psychiatric disorder with frequent recurrent psychotic relapses and progressive functional impairment. It results from a poorly understood gene-environment interaction. The gene encoding catechol-O-methyltransferase (COMT) is a likely candidate for schizophrenia. Its rs165599 (A/G) polymorphism has been shown to be associated with alteration of COMT gene expression. Therefore, the present study aimed to investigate a possible association between schizophrenia and this polymorphism. The distribution of the alleles and genotypes of this polymorphism was investigated in a Brazilian sample of 245 patients and 834 controls. The genotypic frequencies were in Hardy-Weinberg equilibrium and no statistically significant differences were found between cases and controls when analyzed according to gender or schizophrenia subtypes. There was also no difference in homozygosis between cases and controls. Thus, in the sample studied, there was no evidence of any association between schizophrenia and rs165599 (A/G) polymorphism in the non-coding region 3' of the COMT gene.
  •  
10.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 36

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy