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Träfflista för sökning "WFRF:(Cordeiro Q) ;pers:(Vallada H)"

Sökning: WFRF:(Cordeiro Q) > Vallada H

  • Resultat 1-10 av 58
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  • Bertola, V, et al. (författare)
  • Association analysis between the C516T polymorphism in the 5-HT2A receptor gene and schizophrenia
  • 2007
  • Ingår i: Arquivos de neuro-psiquiatria. - : FapUNIFESP (SciELO). - 0004-282X. ; 65:1, s. 11-14
  • Tidskriftsartikel (refereegranskat)abstract
    • Data from epidemiological studies have demonstrated that genetics is an important risk factor for schizophrenia. Disturbances of serotonergic brain pathways have been implicated in the pathophysiology of schizophrenia. Some studies have suggested that the efficacy of atypical antipsychotics on schizophrenia treatment may be related to the serotonin 2A receptor (5-HT2A), and that serotonergic drugs may induce psychotic symptoms. Thus, the aim of this study was to investigate the association between the C516T polymorphism and schizophrenia in a Brazilian population composed by 246 patients and 315 healthy matched controls in a case-control approach. No statistically differences were observed in allelic (chi2=1.77, 1d.f., p=0.18) or genotypic (chi2=1.69, 2d.f., p=0.42) distributions between cases and controls. The results suggest that the C516T polymorphism of the 5-HT2A receptor gene is not related to the susceptibility for schizophrenia in our Brazilian sample.
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  • Cappi, C, et al. (författare)
  • Association study between functional polymorphisms in the TNF-alpha gene and obsessive-compulsive disorder
  • 2012
  • Ingår i: Arquivos de neuro-psiquiatria. - : FapUNIFESP (SciELO). - 1678-4227 .- 0004-282X. ; 70:2, s. 87-90
  • Tidskriftsartikel (refereegranskat)abstract
    • Obsessive-compulsive disorder (OCD) is a prevalent psychiatric disorder of unknown etiology. However, there is some evidence that the immune system may play an important role in its pathogenesis. In the present study, two polymorphisms (rs1800795 and rs361525) in the promoter region of the cytokine tumor necrosis factor-alpha (TNFA) gene were genotyped in 183 OCD patients and in 249 healthy controls. The statistical tests were performed using the PLINK® software. We found that the A allele of the TNFA rs361525 polymorphism was significantly associated with OCD subjects, according to the allelic χ² association test (p=0.007). The presence of genetic markers, such as inflammatory cytokines genes linked to OCD, may represent additional evidence supporting the role of the immune system in its pathogenesis.
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  • Resultat 1-10 av 58

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