↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Tyck till om SwePub Sök här!

Träfflista för sökning "WFRF:(Cornelissen Sten) ;lar1:(ki)"

Sökning: WFRF:(Cornelissen Sten) > Karolinska Institutet

Resultat 1-2 av 2

Sortera/gruppera träfflistan

Sortering: Träffar per sida:

Numrering	Referens	Omslagsbild	Hitta
1.	Mueller, Stefanie H., et al. (författare) Aggregation tests identify new gene associations with breast cancer in populations with diverse ancestry 2023 Ingår i: Genome Medicine. - : BioMed Central (BMC). - 1756-994X .- 1756-994X. ; 15 Tidskriftsartikel (refereegranskat)abstract Background: Low-frequency variants play an important role in breast cancer (BC) susceptibility. Gene-based methods can increase power by combining multiple variants in the same gene and help identify target genes.Methods: We evaluated the potential of gene-based aggregation in the Breast Cancer Association Consortium cohorts including 83,471 cases and 59,199 controls. Low-frequency variants were aggregated for individual genes' coding and regulatory regions. Association results in European ancestry samples were compared to single-marker association results in the same cohort. Gene-based associations were also combined in meta-analysis across individuals with European, Asian, African, and Latin American and Hispanic ancestry.Results: In European ancestry samples, 14 genes were significantly associated (q < 0.05) with BC. Of those, two genes, FMNL3 (P = 6.11 x 10(-6)) and AC058822.1 (P = 1.47 x 10(-4)), represent new associations. High FMNL3 expression has previously been linked to poor prognosis in several other cancers. Meta-analysis of samples with diverse ancestry discovered further associations including established candidate genes ESR1 and CBLB. Furthermore, literature review and database query found further support for a biologically plausible link with cancer for genes CBLB, FMNL3, FGFR2, LSP1, MAP3K1, and SRGAP2C.Conclusions: Using extended gene-based aggregation tests including coding and regulatory variation, we report identification of plausible target genes for previously identified single-marker associations with BC as well as the discovery of novel genes implicated in BC development. Including multi ancestral cohorts in this study enabled the identification of otherwise missed disease associations as ESR1 (P = 1.31 x 10(-5)), demonstrating the importance of diversifying study cohorts.
2.	Wu, Lang, et al. (författare) A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer. 2018 Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 50:7, s. 968-978 Tidskriftsartikel (refereegranskat)abstract , including 14 genes at loci not yet reported for breast cancer. We silenced 13 genes and showed an effect for 11 on cell proliferation and/or colony-forming efficiency. Our study provides new insights into breast cancer genetics and biology.

Skapa referenser, mejla, bekava och länka

Länka till träfflistan

Resultat 1-2 av 2

Avgränsa träffmängd

Typ av publikation: tidskriftsartikel (2)

Typ av innehåll: refereegranskat (2)

Författare/redaktör: Nevanlinna, Heli (2); Blomqvist, Carl (2); Chang-Claude, Jenny (2); Kaaks, Rudolf (2); Wang, Qin (2); Wolk, Alicja (2); visa fler...; Haiman, Christopher ... (2); Brenner, Hermann (2); John, Esther M (2); Gago Dominguez, Manu ... (2); Arndt, Volker (2); Rennert, Gad (2); Michailidou, Kyriaki (2); Bolla, Manjeet K. (2); Dennis, Joe (2); Dunning, Alison M. (2); Andrulis, Irene L. (2); Anton-Culver, Hoda (2); Aronson, Kristan J. (2); Benitez, Javier (2); Bermisheva, Marina (2); Bojesen, Stig E. (2); Czene, Kamila (2); Daly, Mary B. (2); Devilee, Peter (2); Dwek, Miriam (2); Eccles, Diana M. (2); Fasching, Peter A. (2); Guenel, Pascal (2); Hall, Per (2); Hamann, Ute (2); Hopper, John L. (2); Jakubowska, Anna (2); Jones, Michael E. (2); Jung, Audrey (2); Kristensen, Vessela ... (2); Lambrechts, Diether (2); Lo, Wing-Yee (2); Mannermaa, Arto (2); Margolin, Sara (2); Menon, Usha (2); Peto, Julian (2); Plaseska-Karanfilska ... (2); Radice, Paolo (2); Romero, Atocha (2); Saloustros, Emmanoui ... (2); Sandler, Dale P. (2); Sawyer, Elinor J. (2); Schmutzler, Rita K. (2); Shu, Xiao-Ou (2); visa färre...

Lärosäte: Uppsala universitet (2); Lunds universitet (2); Karolinska Institutet (2)Ta bort avgränsningen

Språk: Engelska (2)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (2)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

Copyright © LIBRIS - Nationella bibliotekssystem
LIBRIS.kb.se

pil uppåt

Stäng

Kopiera och spara länken för att återkomma till aktuell vy