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  • Jiang, Xia, et al. (författare)
  • Shared heritability and functional enrichment across six solid cancers
  • 2019
  • Ingår i: Nature Communications. - 2041-1723. ; 10
  • Tidskriftsartikel (refereegranskat)abstract
    • Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10−8), breast and ovarian cancer (rg = 0.24, p = 7 × 10−5), breast and lung cancer (rg = 0.18, p =1.5 × 10−6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10−4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis. © 2019, The Author(s).
  • Aaltonen, T., et al. (författare)
  • Combination of Tevatron Searches for the Standard Model Higgs Boson in the W+W- Decay Mode
  • 2010
  • Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 104:6, s. 061802
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>We combine searches by the CDF and D0 Collaborations for a Higgs boson decaying to W+W-. The data correspond to an integrated total luminosity of 4.8 (CDF) and 5.4 (D0) fb(-1) of p (p) over bar collisions at root s = 1.96 TeV at the Fermilab Tevatron collider. No excess is observed above background expectation, and resulting limits on Higgs boson production exclude a standard model Higgs boson in the mass range 162-166 GeV at the 95% C.L.</p>
  • Aaltonen, T., et al. (författare)
  • Tevatron Run II combination of the effective leptonic electroweak mixing angle
  • 2018
  • Ingår i: Physical Review D : covering particles, fields, gravitation, and cosmology. - AMER PHYSICAL SOC. - 2470-0010 .- 2470-0029. ; 97:11
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Drell-Yan lepton pairs produced in the process p (p) over bar -&gt; l(+)l(-) + X through an intermediate gamma*/Z boson have an asymmetry in their angular distribution related to the spontaneous symmetry breaking of the electroweak force and the associated mixing of its neutral gauge bosons. The CDF and D0 experiments have measured the effective-leptonic electroweak mixing parameter sin(2) theta(lept)(eff) using electron and muon pairs selected from the full Tevatron proton-antiproton data sets collected in 2001-2011, corresponding to 9-10 fb(-1) of integrated luminosity. The combination of these measurements yields the most precise result from hadron colliders, sin(2)theta(lept)(eff) = 0.23148 +/- 0.00033. This result is consistent with, and approaches in precision, the best measurements from electron-positron colliders. The standard model inference of the on-shell electroweak mixing parameter sin(2) theta(W), or equivalently the W-boson mass M-W, using the ZFITTER software package yields sin(2) theta(W) = 0.22324 +/- 0.00033 or equivalently, M-W = 80.367 +/- 0.017 GeV/c(2).</p>
  • Aaltonen, T., et al. (författare)
  • Combination of CDF and D0 measurements of the W boson helicity in top quark decays
  • 2012
  • Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 85:7, s. 071106
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>We report the combination of recent measurements of the helicity of the W boson from top quark decay by the CDF and D0 collaborations, based on data samples corresponding to integrated luminosities of 2.7-5.4 fb(-1) of p (p) over bar collisions collected during Run II of the Fermilab Tevatron collider. Combining measurements that simultaneously determine the fractions of W bosons with longitudinal (f(0)) and right-handed (f(+)) helicities, we find f(0) = 0.722 +/- 0.081[+/- 0.062(stat) +/- 0.052(syst)] and f(+) = -0.033 +/- 0.046[+/- 0.034(stat) +/- 0.031(syst)]. Combining measurements where one of the helicity fractions is fixed to the value expected in the standard model, we find f(0) = 0.682 +/- 0.057[+/- 0.035(stat) +/- 0.046(syst)] for fixed f(+) and f(+) = -0.015 +/- 0.035[+/- 0.018(stat) +/- 0.030(syst)] for fixed f(0). The results are consistent with standard model expectations.</p>
  • Aaltonen, T., et al. (författare)
  • Combined Forward-Backward Asymmetry Measurements in Top-Antitop Quark Production at the Tevatron
  • 2018
  • Ingår i: Physical Review Letters. - AMER PHYSICAL SOC. - 0031-9007 .- 1079-7114. ; 120:4
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>The CDF and D0 experiments at the Fermilab Tevatron have measured the asymmetry between yields of forward- and backward-produced top and antitop quarks based on their rapidity difference and the asymmetry between their decay leptons. These measurements use the full data sets collected in proton-antiproton collisions at a center-of-mass energy of root s = 1.96 TeV. We report the results of combinations of the inclusive asymmetries and their differential dependencies on relevant kinematic quantities. The combined inclusive asymmetry is A(FB)(t (t) over bar) = 0.128 +/- 0.025. The combined inclusive and differential asymmetries are consistent with recent standard model predictions.</p>
  • Aaltonen, T., et al. (författare)
  • Higgs boson studies at the Tevatron
  • 2013
  • Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 88:5, s. 052014
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>We combine searches by the CDF and D0 Collaborations for the standard model Higgs boson with mass in the range 90-200 GeV/c(2) produced in the gluon-gluon fusion, WH, ZH, t (t) over barH, and vector boson fusion processes, and decaying in the H -&gt; b (b) over bar, H -&gt; W+W-, H -&gt; ZZ, H -&gt; tau(+)tau(-), and H -&gt; gamma gamma modes. The data correspond to integrated luminosities of up to 10 fb(-1) and were collected at the Fermilab Tevatron in p (p) over bar collisions at root s = 1.96 TeV. The searches are also interpreted in the context of fermiophobic and fourth generation models. We observe a significant excess of events in the mass range between 115 and 140 GeV/c(2). The local significance corresponds to 3.0 standard deviations at m(H) = 125 GeV/c(2), consistent with the mass of the Higgs boson observed at the LHC, and we expect a local significance of 1.9 standard deviations. We separately combine searches for H -&gt; b (b) over bar, H -&gt; W+W-, H -&gt; tau(+)tau(-), and H -&gt; gamma gamma. The observed signal strengths in all channels are consistent with the presence of a standard model Higgs boson with a mass of 125 GeV/c(2).</p>
  • Aaltonen, T., et al. (författare)
  • Tevatron Combination of Single-Top-Quark Cross Sections and Determination of the Magnitude of the Cabibbo-Kobayashi-Maskawa Matrix Element V-tb
  • 2015
  • Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 115:15
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>We present the final combination of CDF and D0 measurements of cross sections for single-top-quark production in proton-antiproton collisions at a center-of-mass energy of 1.96 TeV. The data correspond to total integrated luminosities of up to 9.7 fb(-1) per experiment. The t-channel cross section is measured to be sigma(t) = 2.25(-0.31)(+0.29) pb. We also present the combinations of the two-dimensional measurements of the s- vs t-channel cross section. In addition, we give the combination of the s + t channel cross section measurement resulting in sigma(s+t) = 3.30(-0.40)(+0.52) pb, without assuming the standard model value for the ratio sigma(s)/sigma(t). The resulting value of the magnitude of the top-to-bottom quark coupling is vertical bar V-tb vertical bar = 1.02(-0.05)(+0.06), corresponding to vertical bar V-tb vertical bar &gt; 0.92 at the 95% C. L.</p>
  • Abazov, V. M., et al. (författare)
  • Experimental discrimination between charge 2e/3 top quark and charge 4e/3 exotic quark production scenarios
  • 2007
  • Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 98:4, s. 041801
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>We present the first experimental discrimination between the 2e/3 and 4e/3 top quark electric charge scenarios, using top quark pairs (t (t) over bar) produced in p (p) over bar collisions at root s =1.96 TeV by the Fermilab Tevatron Collider. We use 370 pb(-1) of data collected by the D0 experiment and select events with at least one high transverse momentum electron or muon, high transverse energy imbalance, and four or more jets. We discriminate between b- and (b) over bar -quark jets by using the charge and momenta of tracks within the jet cones. The data are consistent with the expected electric charge, |q|=2e/3. We exclude, at the 92% C.L., that the sample is solely due to the production of exotic quark pairs Q (Q) over bar with |q|=4e/3. We place an upper limit on the fraction of Q (Q) over bar pairs rho &lt; 0.80 at the 90% C.L.</p>
  • Abazov, V. M., et al. (författare)
  • Limits on anomalous trilinear gauge couplings from WW -&gt; e(+)e(-), WW -&gt; e(+/-)mu(-/+), and WW -&gt;mu(+)mu(-) events from pp collisions at root s=1.96 TeV
  • 2006
  • Ingår i: Physical Review D - Particles, Fields, Gravitation and Cosmology. - 1550-7998. ; 74:5, s. 057101
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Limits are set on anomalous WW gamma and WWZ trilinear gauge couplings using W+W--&gt; e(+)nu(e)e(-)(nu) over bar (e), W+W--&gt; e(+/-)nu(e)mu(-/+)nu(mu), and W+W--&gt;mu(+)nu(mu)mu(-)(nu) over bar (mu) events. The data set was collected by the Run II D0 detector at the Fermilab Tevatron Collider and corresponds to approximately 250 pb(-1) of integrated luminosity at root s=1.96 TeV. Under the assumption that the WW gamma couplings are equal to the WWZ couplings and using a form factor scale of Lambda=2.0 TeV, the combined 95% C.L. one-dimensional coupling limits from all three channels are -0.32 &lt;Delta kappa &lt; 0.45 and -0.29 &lt;lambda &lt; 0.30.</p>
  • Abazov, V. M., et al. (författare)
  • Measurement of the CP-violation parameter of B-0 mixing and decay with p(p)over-bar -&gt;mu mu X data
  • 2006
  • Ingår i: Physical Review D - Particles, Fields, Gravitation and Cosmology. - 1550-7998. ; 74:9, s. 092001
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>We measure the dimuon charge asymmetry A in p (p) over bar collisions at a center of mass energy root s=1960 GeV. The data was recorded with the D0 detector and corresponds to an integrated luminosity of approximately 1.0 fb(-1). Assuming that the asymmetry A is due to asymmetric B-0 &lt;-&gt;(B) over bar (0) mixing and decay, we extract the CP-violation parameter of B-0 mixing and decay: ((epsilon B0))/(1+vertical bar epsilon B0 vertical bar 2)=(AB0)/(4)= -0.0023 +/- 0.0011(stat)+/- 0.0008(syst).A(B)(0) is the dimuon charge asymmetry from decays of B-0(B) over bar (0) pairs. The general case, with CP violation in both B-0 and B-s(0) systems, is also considered. Finally we obtain the forward-backward asymmetry that quantifies the tendency of mu(+) to go in the proton direction and mu(-) to go in the antiproton direction. The results are consistent with the standard model and constrain new physics.</p>
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