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Blood pressure regulation by CD4+ lymphocytes expressing choline acetyltransferase

Olofsson, Peder S. (author)
Karolinska Institutet,Center for Bioelectronic Medicine, Department of Medicine, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden / Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, New York, USA
Steinberg, Benjamin E. (author)
Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, New York, USA / The Campbell Family Institute for Breast Cancer Research, University Health Network, Toronto, Ontario, Canada
Sobbi, Roozbeh (author)
Division of Cardiology, Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada
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Cox, Maureen A. (author)
The Campbell Family Institute for Breast Cancer Research, University Health Network, Toronto, Ontario, Canada,Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
Ahmed, Mohamed N. (author)
Center for Heart and Lung Research, The Feinstein Institute for Medical Research, Manhasset, New York, USA
Oswald, Michaela (author)
Robert S. Boas Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, New York, USA
Szekeres, Ferenc (author)
Högskolan i Skövde,Institutionen för hälsa och lärande,Forskningsspecialiseringen Hälsa och Lärande,Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden,Äldre och långvariga hälsoproblem, Health and Ageing
Hanes, William M. (author)
Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, New York, USA
Introini, Andrea (author)
Karolinska Institutet,Department of Medicine, Solna, Unit of Infectious Diseases, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Liu, Shu Fang (author)
Center for Heart and Lung Research, The Feinstein Institute for Medical Research, Manhasset, New York, USA
Holodick, Nichol E. (author)
Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research, Manhasset, New York, USA
Rothstein, Thomas L. (author)
Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research, Manhasset, New York, USA
Lövdahl, Cecilia (author)
Karolinska Institutet,Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
Chavan, Sangeeta S. (author)
Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, New York, USA
Yang, Huan (author)
Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, New York, USA
Pavlov, Valentin A. (author)
Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, New York, USA
Broliden, Kristina (author)
Karolinska Institutet,Department of Medicine, Solna, Unit of Infectious Diseases, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Andersson, Ulf (author)
Karolinska Institutet,Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden
Diamond, Betty (author)
The Center for Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, Manhasset, New York, USA
Miller, Edmund J. (author)
Center for Heart and Lung Research, The Feinstein Institute for Medical Research, Manhasset, New York, USA
Arner, Anders (author)
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
Gregersen, Peter K. (author)
Robert S. Boas Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, New York, USA
Backx, Peter H. (author)
Division of Cardiology, Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada / Department of Biology, York University, Toronto, Ontario, Canada
Mak, Tak W. (author)
The Campbell Family Institute for Breast Cancer Research, University Health Network, Toronto, Ontario, Canada
Tracey, Kevin J. (author)
Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, New York, USA
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 (creator_code:org_t)
2016-09-12
2016
English.
In: Nature Biotechnology. - : Nature Publishing Group. - 1087-0156 .- 1546-1696. ; 34:10, s. 1066-1071
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Blood pressure regulation is known to be maintained by a neuro-endocrine circuit, but whether immune cells contribute to blood pressure homeostasis has not been determined. We previously showed that CD4(+) T lymphocytes that express choline acetyltransferase (ChAT), which catalyzes the synthesis of the vasorelaxant acetylcholine, relay neural signals(1). Here we show that these CD4(+)CD44(hi)CD62L(Io) T helper cells by gene expression are a distinct T-cell population defined by ChAT (CD4 T-ChAT). Mice lacking ChAT expression in CD4(+) cells have elevated arterial blood pressure, compared to littermate controls. Jurkat T cells overexpressing ChAT (JT(ChAT)) decreased blood pressure when infused into mice. Co-incubation of JT(ChAT) and endothelial cells increased endothelial cell levels of phosphorylated endothelial nitric oxide synthase, and of nitrates and nitrites in conditioned media, indicating increased release of the potent vasorelaxant nitric oxide. The isolation and characterization of CD4 T-ChAT cells will enable analysis of the role of these cells in hypotension and hypertension, and may suggest novel therapeutic strategies by targeting cell-mediated vasorelaxation.

Subject headings

NATURVETENSKAP  -- Biologi -- Cellbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Cell Biology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Physiology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Keyword

CD4-positive T cells
Experimental models of disease
Hypertension
Mechanisms of disease
Neuro–vascular interactions
Äldre och åldrande
Age and Ageing

Publication and Content Type

ref (subject category)
art (subject category)

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