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1.	Persson, J, et al. (author) Altered brain white-matter integrity in non-demented carriers of the APOE ε4 allele: A risk for Alzheimer’s disease. 2006 In: Neurology. - : Ovid Technologies (Wolters Kluwer Health). - 0028-3878 .- 1526-632X. ; 66:7, s. 1029-1033 Journal article (peer-reviewed)abstract Previous research has shown that polymorphisms of the apolipoprotein E (APOE) represent genetic risk factors for dementia and for cognitive impairment in the elderly. The neural mechanisms by which these genetic variations influence behavioral performance or clinical severity are not well understood. We used diffusion tensor imaging to investigate ultrastructural properties in brain white-matter to detect pathological processes that modify tissue integrity. Sixty participants were included in the study of which 30 were homozygous for the APOE ε3 allele, 10 were homozygous for the APOE ε4 allele, and 20 had the APOE ε34 allele combination. All individuals were non-demented, and the groups were matched on demographic variables and cognitive performance. The results showed a decline in fractional anisotropy, a marker for white-matter integrity, in the posterior corpus callosum of ε4 carriers compared to non-carriers. Additional sites of altered white-matter integrity included the medial temporal lobe. Conclusions: Although the mechanism underlying vulnerability of white matter tracts in APOE ε4 carriers is still unknown, our findings suggest that increased genetic risk for developing AD is associated with changes in microscopic white-matter integrity well before the onset of dementia.
2.	Nilsson, LG, et al. (author) Associations between alleles of apolipoproteine and memory performance in non-demented individuals 2002 In: AMERICAN JOURNAL OF MEDICAL GENETICS. - 0148-7299. ; 114:7, s. 730-731 Conference paper (other academic/artistic)
3.	Nilsson, LG, et al. (author) Impairment of episodic memory and word fluency in carriers of the APOE(a)over-circle4 allele 2004 In: BEHAVIOR GENETICS. - 0001-8244. ; 34:6, s. 654-654 Conference paper (other academic/artistic)
4.	Nilsson, LG, et al. (author) Normal memory development and the role of ApolipoproteinE: The Betula study 2000 In: INTERNATIONAL JOURNAL OF PSYCHOLOGY. - : PSYCHOLOGY PRESS. - 0020-7594. ; 35:3-4 Other publication (other academic/artistic)
5.	Nilsson, LG, et al. (author) The role of ApolipoproteinE as a predictor for dementia in a nondemented population 2000 In: INTERNATIONAL JOURNAL OF PSYCHOLOGY. - : PSYCHOLOGY PRESS. - 0020-7594. ; 35:3-4 Other publication (other academic/artistic)
6.	Sundström, A., et al. (author) Fatigue before and after mild head injury : pre-post injury comparisons in relation to Apolipoprotein E Other publication (other academic/artistic)

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Type of publication: other publication (3); conference paper (2); journal article (1)

Type of content: other academic/artistic (5); peer-reviewed (1)

Author/Editor: Adolfsson, R. (6); Nyberg, L (6)Undo refine; Cruts, M (6); Backman, L (4); Van Broeckhoven, C (4); Nilsson, LG (4); show more...; Edvardsson, H. (2); Ingvar, M (1); Persson, J. (1); Larsson, A (1); Nilsson, Lars-Göran (1); Nilsson, L-G (1); Small, BJ (1); Sundström, A (1); Lind, J. (1); Van Broekhoven, C (1); Van Broeckoven, C (1); show less...

University: Karolinska Institutet (4); Uppsala University (2); Umeå University (1); Stockholm University (1)

Language: English (6)

Research subject (UKÄ/SCB): Social Sciences (1)

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