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Träfflista för sökning "WFRF:(Cui Tao) "

Sökning: WFRF:(Cui Tao)

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1.
  • Akhtar, Farid, et al. (författare)
  • TiB 2 and TiC stainless steel matrix composites
  • 2007
  • Ingår i: Materials letters (General ed.). - 0167-577X .- 1873-4979. ; 61:1, s. 189-191
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Stainless steel matrix composites reinforced with TiB2 or TiC particulates have been in situ produced through the reactive sintering of Ti, C and FeB. X-ray diffraction analysis confirmed the completion of reaction. The TiB2, TiC and steel were detected by X-ray diffraction analysis. No other reaction product or boride was found, indicating the stability of TiB2 and TiC in steel matrix. The SEM micrographs revealed the morphology and distribution of in situ synthesized TiB2 and TiC reinforcements in steel matrix. During sintering the reinforcements TiB2 and TiC grew in different shapes. TiB2 grew in hexagonal prismatic and rectangular shape and TiC in spherical shape.</p>
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  • Cao, Hong Min, et al. (författare)
  • The loud and the quiet: Searching for radio counterparts of two radio-weak BL Lac candidates with VLBI
  • 2019
  • Ingår i: Monthly Notices of the Royal Astronomical Society: Letters. - 17453925 .- 17453933. ; 482:1, s. L34-L39
  • Tidskriftsartikel (refereegranskat)abstract
    • BL Lac objects are known to have compact jets inclined to our line of sight at a small angle, showing prominent radio emission. Two radio-weak BL Lac candidates with no counterparts in current radio surveys were recently reported by Massaro et al. Both sources were selected as candidate low-energy counterparts of unassociated Fermi γ -ray sources. We carried out very long baseline interferometry (VLBI) observations with the European VLBI Network (EVN) at 5 GHz to explore their radio properties at the milliarcsecond (mas) scale. One target, J1410+7405, is clearly detected with the EVN. Its measured 5-GHz flux density, 2.4 mJy, is consistent with recent interferometricmeasurementswith theKarlG. JanskyVery LargeArray, suggesting that the radio emission is confined to the inner ≲10-mas region. J1410+7405 is therefore identified as a radio-loud jetted active galactic nucleus, and its brightness temperature exceeds ~109 K. Its properties are similar to those of other γ -ray-detected BL Lac objects. On the other hand, the second target, J0644+6031, remains undetected with the EVN with a 6s brightness upper limit of 0.12 mJy beam-1. This source is thus radio-quiet, confirming its peculiarity, or possibly questioning its BL Lac nature.
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4.
  • Chen, XÍ, et al. (författare)
  • TDHQ Enabling Fine-granularity Adaptive Loading for SSB-DMT Systems
  • 2018
  • Ingår i: IEEE Photonics Technology Letters. - 1041-1135 .- 1941-0174. ; 30:19, s. 1687-1690
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>In this letter, we introduce time domain hybrid quadrature amplitude modulation (TDHQ) for the single sideband (SSB) discrete multi-tone (DMT) systems. Experimental results reveal that with a single precoding set and the proposed adaptive loading algorithm, the TDHQ scheme can achieve finer granularity and therefore smoother continuous growth of data rate than that with the conventional quadrature amplitude modulation (QAM). Besides, thanks to the frame construction and the tailored mapping rule, the scheme with TDHQ has an obviously better peak to average power ratio (PAPR).</p>
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5.
  • Cui, Tao, 1982- (författare)
  • Novel Circulating and Tissue Biomarkers for Small Intestine Neuroendocrine Tumors and Lung Carcinoids
  • 2013
  • Doktorsavhandling (övrigt vetenskapligt)abstract
    • <p>Small intestine neuroendocrine tumors (SI-NETs) and lung carcinoids (LCs) are relatively indolent tumors, which originate from neuroendocrine (NE) cells of the diffuse NE system. Metastases can spread before diagnosis. Thus, potential cures become unavailable, which entitles new biomarker development. Indeed, we aimed at developing Ma2 autoantibodies and olfactory receptor 51E1 (OR51E1) as potential novel biomarkers and exploring other candidate protein markers in patients’ serum.</p><p>First, we established a sensitive, specific and reliable anti-Ma2 indirect ELISA to distinguish SI-NET patients from healthy controls. We detected longer progression-free and recurrence-free survivals in patients expressing low anti-Ma2 titers. Moreover, a high anti-Ma2 titer was more sensitive than chromogranin A for the risk of recurrence after radical operation of SI-NET patients.</p><p>We then investigated OR51E1 expression in SI-NETs and LCs. OR51E1 mRNA expression, analyzed by quantitative real-time PCR, was high in microdissected SI-NET cells, in LC cell lines and in frozen LC specimens. Immunohistochemistry (IHC) showed abundant OR51E1 protein expression in SI-NETs. OR51E1 co-expressed with vesicular-monoamine-transporter-1 in the majority of normal and neoplastic enterochromaffin cells.</p><p>Furthermore, the study on LCs revealed that OR51E1, somatostatin receptor (SSTR) 2, SSTR3, and SSTR5 are expressed in 85%, 71%, 25% and 39% of typical carcinoids (TCs), whereas in 86%, 79%, 43% and 36% of atypical carcinoids (ACs). Based on the proposed IHC scoring system, in the LC cases, where all SSTR subtypes were absent, membrane OR51E1 expression was detected in 10 out of 17 TCs and 1 out of 2 ACs. Moreover, higher OR51E1 scores were detected in 5 out of 6 OctreoScan-negative LC lesions.</p><p>In addition, the last presented study used a novel suspension bead array, which targeted 124 unique proteins, by using Human Protein Atlas antibodies, to profile biotinylated serum samples from SI-NET patients and healthy controls. We showed 9 proteins, IGFBP2, IGF1, SHKBP1, ETS1, IL1α, STX2, MAML3, EGR3 and XIAP as significant contributors to tumor classification.</p><p>In conclusion, we proposed Ma2 autoantibodies as a sensitive circulating marker for SI-NET recurrence; OR51E1 as a candidate therapeutic target for SI-NETs; whereas as a novel diagnostic marker for LCs and 9 serum proteins as novel potential SI-NET markers.</p>
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8.
  • Cui, Tao, et al. (författare)
  • Olfactory receptor 51E1 protein as a potential novel tissue biomarker for small intestine neuroendocrine carcinomas
  • 2013
  • Ingår i: European Journal of Endocrinology. - 0804-4643 .- 1479-683X. ; 168:2, s. 253-261
  • Tidskriftsartikel (refereegranskat)abstract
    • <p><strong>OBJECTIVE:</strong> Late diagnosis hinders proper management of small intestine neuroendocrine carcinoma (SI-NEC) patients. The olfactory receptor, family 51, subfamily E, member 1 (OR51E1) has been reported as a potential novel SI-NEC marker, without protein expression recognition. Thus, we further studied whether the encoded protein may be a novel SI-NEC clinical biomarker.</p><p><strong>DESIGN:</strong> OR51E1 coding sequence was cloned using total RNA from SI-NEC patient specimens. Quantitative real-time PCR analysis explored OR51E1 expression in laser capture microdissected SI-NEC cells and adjacent microenvironment cells. Moreover, immunohistochemistry investigated OR51E1 protein expression on operation and biopsy material from primary SI-NECs, mesentery, and liver metastases from 70 patients. Furthermore, double immunofluorescence studies explored the potential co-localization of the vesicular monoamine transporter 1 (SLC18A1, generally referred to as VMAT1) and OR51E1 in the neoplastic cells and in the intestinal mucosa adjacent to the tumor.</p><p><strong>RESULTS:</strong> OR51E1 coding sequence analysis showed absence of mutation in SI-NEC patients at different stages of disease. OR51E1 expression was higher in microdissected SI-NEC cells than in the adjacent microenvironment cells. Furthermore, both membranous and cytoplasmic OR51E1 immunostaining patterns were detected in both primary SI-NECs and metastases. Briefly, 18/43 primary tumors, 7/28 mesentery metastases, and 6/18 liver metastases were 'positive' for OR51E1 in more than 50% of the tumor cells. In addition, co-localization studies showed that OR51E1 was expressed in &gt;50% of the VMAT1 immunoreactive tumor cells and of the enterochromaffin cells in the intestinal mucosa adjacent to the tumor.</p><p><strong>CONCLUSION:</strong> OR51E1 protein is a potential novel clinical tissue biomarker for SI-NECs. Moreover, we suggest its potential therapeutic molecular target development using solid tumor radioimmunotherapy.</p>
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9.
  • Cui, Tao, et al. (författare)
  • Paraneoplastic antigen Ma2 autoantibodies as specific blood biomarkers for detection of early recurrence of small intestine neuroendocrine tumors
  • 2010
  • Ingår i: PLoS ONE. - 1932-6203 .- 1932-6203. ; 5:12, s. e16010
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Background: Small intestine neuroendocrine tumors (SI-NETs) belong to a rare group of cancers. Most patients have developed metastatic disease at the time of diagnosis, for which there is currently no cure. The delay in diagnosis is a major issue in the clinical management of the patients and new markers are urgently needed. We have previously identified paraneoplastic antigen Ma2 (PNMA2) as a novel SI-NET tissue biomarker. Therefore, we evaluated whether Ma2 autoantibodies detection in the blood stream is useful for the clinical diagnosis and recurrence of SI-NETs. Methodology/Principal Findings: A novel indirect ELISA was set up to detect Ma2 autoantibodies in blood samples of patients with SI-NET at different stages of disease. The analysis was extended to include typical and atypical lung carcinoids (TLC and ALC), to evaluate whether Ma2 autoantibodies in the blood stream become a general biomarker for NETs. In total, 124 blood samples of SI-NET patients at different stages of disease were included in the study. The novel Ma2 autoantibody ELISA showed high sensitivity, specificity and accuracy with ROC curve analysis underlying an area between 0.734 and 0.816. Ma2 autoantibodies in the blood from SI-NET patients were verified by western blot and sequential immunoprecipitation. Serum antibodies of patients stain Ma2 in the tumor tissue and neurons. We observed that SI-NET patients expressing Ma2 autoantibody levels below the cutoff had a longer progression and recurrence-free survival compared to those with higher titer. We also detected higher levels of Ma2 autoantibodies in blood samples from TLC and ALC patients than from healthy controls, as previously shown in small cell lung carcinoma samples. Conclusion: Here we show that high Ma2 autoantibody titer in the blood of SI-NET patients is a sensitive and specific biomarker, superior to chromogranin A (CgA) for the risk of recurrence after radical operation of these tumors.</p><p> </p>
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10.
  • Cui, Yong, et al. (författare)
  • Over 16% efficiency organic photovoltaic cells enabled by a chlorinated acceptor with increased open-circuit voltages
  • 2019
  • Ingår i: Nature Communications. - NATURE PUBLISHING GROUP. - 2041-1723 .- 2041-1723. ; 10
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Broadening the optical absorption of organic photovoltaic (OPV) materials by enhancing the intramolecular push-pull effect is a general and effective method to improve the power conversion efficiencies of OPV cells. However, in terms of the electron acceptors, the most common molecular design strategy of halogenation usually results in down-shifted molecular energy levels, thereby leading to decreased open-circuit voltages in the devices. Herein, we report a chlorinated non-fullerene acceptor, which exhibits an extended optical absorption and meanwhile displays a higher voltage than its fluorinated counterpart in the devices. This unexpected phenomenon can be ascribed to the reduced non-radiative energy loss (0.206 eV). Due to the simultaneously improved short-circuit current density and open-circuit voltage, a high efficiency of 16.5% is achieved. This study demonstrates that finely tuning the OPV materials to reduce the bandgap-voltage offset has great potential for boosting the efficiency.</p>
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