SwePub
Tyck till om SwePub Sök här!
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Cummings Steven R.) ;pers:(Oostra Ben A.)"

Sökning: WFRF:(Cummings Steven R.) > Oostra Ben A.

  • Resultat 1-3 av 3
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Estrada, Karol, et al. (författare)
  • Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
  • 2012
  • Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 44:5, s. 491-501
  • Tidskriftsartikel (refereegranskat)abstract
    • Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and east Asian ancestry. We tested the top BMD-associated markers for replication in 50,933 independent subjects and for association with risk of low-trauma fracture in 31,016 individuals with a history of fracture (cases) and 102,444 controls. We identified 56 loci (32 new) associated with BMD at genome-wide significance (P < 5 × 10(-8)). Several of these factors cluster within the RANK-RANKL-OPG, mesenchymal stem cell differentiation, endochondral ossification and Wnt signaling pathways. However, we also discovered loci that were localized to genes not known to have a role in bone biology. Fourteen BMD-associated loci were also associated with fracture risk (P < 5 × 10(-4), Bonferroni corrected), of which six reached P < 5 × 10(-8), including at 18p11.21 (FAM210A), 7q21.3 (SLC25A13), 11q13.2 (LRP5), 4q22.1 (MEPE), 2p16.2 (SPTBN1) and 10q21.1 (DKK1). These findings shed light on the genetic architecture and pathophysiological mechanisms underlying BMD variation and fracture susceptibility.
  •  
2.
  • Lu, Yingchang, et al. (författare)
  • New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
  • 2016
  • Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7
  • Tidskriftsartikel (refereegranskat)abstract
    • To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.
  •  
3.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-3 av 3
Typ av publikation
tidskriftsartikel (3)
Typ av innehåll
refereegranskat (3)
Författare/redaktör
Vandenput, Liesbeth, ... (3)
Ohlsson, Claes, 1965 (3)
van Duijn, Cornelia ... (3)
Oostra, Ben A. (3)Ta bort avgränsningen
Wilson, James F. (3)
Zillikens, M. Carola (3)
visa fler...
Rivadeneira, Fernand ... (3)
Harris, Tamara B (3)
Liu, Yongmei (3)
Hofman, Albert (3)
Uitterlinden, André ... (3)
Khaw, Kay-Tee (2)
Karlsson, Magnus (2)
Lorentzon, Mattias, ... (2)
Salomaa, Veikko (2)
Jula, Antti (2)
Perola, Markus (2)
Lind, Lars (2)
Campbell, Harry (2)
Rudan, Igor (2)
Wareham, Nicholas J. (2)
Stancáková, Alena (2)
Kuusisto, Johanna (2)
Laakso, Markku (2)
Eriksson, Joel (2)
Amin, Najaf (2)
Boehnke, Michael (2)
Ingelsson, Erik (2)
Ripatti, Samuli (2)
Kähönen, Mika (2)
Lehtimäki, Terho (2)
Thorleifsson, Gudmar (2)
Thorsteinsdottir, Un ... (2)
Stefansson, Kari (2)
Rotter, Jerome I. (2)
Shuldiner, Alan R. (2)
Mellström, Dan, 1945 (2)
Gieger, Christian (2)
Peters, Annette (2)
Walker, Mark (2)
Spector, Timothy D (2)
Luan, Jian'an (2)
Hsu, Yi-Hsiang (2)
Michaëlsson, Karl (2)
Eriksson, Johan G. (2)
Lindgren, Cecilia (2)
Ljunggren, Östen (2)
Evans, David M (2)
Garcia, Melissa (2)
Loos, Ruth J F (2)
visa färre...
Lärosäte
Göteborgs universitet (3)
Umeå universitet (2)
Uppsala universitet (2)
Lunds universitet (2)
Karolinska Institutet (1)
Språk
Engelska (3)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (3)
Naturvetenskap (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy