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Variants in MTNR1B influence fasting glucose levels

Prokopenko, Inga (author)
Langenberg, Claudia (author)
Florez, Jose C. (author)
show more...
Saxena, Richa (author)
Soranzo, Nicole (author)
Thorleifsson, Gudmar (author)
Loos, Ruth J. F. (author)
Manning, Alisa K. (author)
Jackson, Anne U. (author)
Aulchenko, Yurii (author)
Potter, Simon C. (author)
Erdos, Michael R. (author)
Sanna, Serena (author)
Hottenga, Jouke-Jan (author)
Wheeler, Eleanor (author)
Kaakinen, Marika (author)
Lyssenko, Valeriya (author)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
Chen, Wei-Min (author)
Ahmadi, Kourosh (author)
Beckmann, Jacques S. (author)
Bergman, Richard N. (author)
Bochud, Murielle (author)
Bonnycastle, Lori L. (author)
Buchanan, Thomas A. (author)
Cao, Antonio (author)
Cervino, Alessandra (author)
Coin, Lachlan (author)
Collins, Francis S. (author)
Crisponi, Laura (author)
De Geus, Eco J. C. (author)
Dehghan, Abbas (author)
Deloukas, Panos (author)
Doney, Alex S. F. (author)
Elliott, Paul (author)
Freimer, Nelson (author)
Gateva, Vesela (author)
Herder, Christian (author)
Hofman, Albert (author)
Hughes, Thomas E. (author)
Hunt, Sarah (author)
Illig, Thomas (author)
Inouye, Michael (author)
Isomaa, Bo (author)
Johnson, Toby (author)
Kong, Augustine (author)
Krestyaninova, Maria (author)
Kuusisto, Johanna (author)
Laakso, Markku (author)
Lim, Noha (author)
Lindblad, Ulf (author)
Gothenburg University,Göteborgs universitet,Lund University,Lunds universitet,Samhällsmedicin,Forskargrupper vid Lunds universitet,Community Medicine,Lund University Research Groups,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
Lindgren, Cecilia M. (author)
McCann, Owen T. (author)
Mohlke, Karen L. (author)
Morris, Andrew D. (author)
Naitza, Silvia (author)
Orru, Marco (author)
Palmer, Colin N. A. (author)
Pouta, Anneli (author)
Randall, Joshua (author)
Rathmann, Wolfgang (author)
Saramies, Jouko (author)
Scheet, Paul (author)
Scott, Laura J. (author)
Scuteri, Angelo (author)
Sharp, Stephen (author)
Sijbrands, Eric (author)
Smit, Jan H. (author)
Song, Kijoung (author)
Steinthorsdottir, Valgerdur (author)
Stringham, Heather M. (author)
Tuomi, Tiinamaija (author)
Tuomilehto, Jaakko (author)
Uitterlinden, Andre G. (author)
Voight, Benjamin F. (author)
Waterworth, Dawn (author)
Wichmann, H-Erich (author)
Willemsen, Gonneke (author)
Witteman, Jacqueline C. M. (author)
Yuan, Xin (author)
Zhao, Jing Hua (author)
Zeggini, Eleftheria (author)
Schlessinger, David (author)
Sandhu, Manjinder (author)
Boomsma, Dorret I. (author)
Uda, Manuela (author)
Spector, Tim D. (author)
Penninx, Brenda W. J. H. (author)
Altshuler, David (author)
Vollenweider, Peter (author)
Jarvelin, Marjo Riitta (author)
Lakatta, Edward (author)
Waeber, Gerard (author)
Fox, Caroline S. (author)
Peltonen, Leena (author)
Groop, Leif (author)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
Mooser, Vincent (author)
Cupples, L. Adrienne (author)
Thorsteinsdottir, Unnur (author)
Boehnke, Michael (author)
Barroso, Ines (author)
Van Duijn, Cornelia (author)
Dupuis, Josee (author)
Watanabe, Richard M. (author)
Stefansson, Kari (author)
McCarthy, Mark I. (author)
Wareham, Nicholas J. (author)
Meigs, James B. (author)
Abecasis, Goncalo R. (author)
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 (creator_code:org_t)
2008-12-07
2009
English.
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 41:1, s. 77-81
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • To identify previously unknown genetic loci associated with fasting glucose concentrations, we examined the leading association signals in ten genome-wide association scans involving a total of 36,610 individuals of European descent. Variants in the gene encoding melatonin receptor 1B (MTNR1B) were consistently associated with fasting glucose across all ten studies. The strongest signal was observed at rs10830963, where each G allele (frequency 0.30 in HapMap CEU) was associated with an increase of 0.07 (95% CI = 0.06-0.08) mmol/l in fasting glucose levels (P = 3.2 x 10(-50)) and reduced beta-cell function as measured by homeostasis model assessment (HOMA-B, P = 1.1 x 10(-15)). The same allele was associated with an increased risk of type 2 diabetes (odds ratio = 1.09 (1.05-1.12), per G allele P = 3.3 x 10(-7)) in a meta-analysis of 13 case-control studies totaling 18,236 cases and 64,453 controls. Our analyses also confirm previous associations of fasting glucose with variants at the G6PC2 (rs560887, P = 1.1 x 10(-57)) and GCK (rs4607517, P = 1.0 x 10(-25)) loci.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Allmänmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- General Practice (hsv//eng)

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By the author/editor
Prokopenko, Inga
Langenberg, Clau ...
Florez, Jose C.
Saxena, Richa
Soranzo, Nicole
Thorleifsson, Gu ...
show more...
Loos, Ruth J. F.
Manning, Alisa K ...
Jackson, Anne U.
Aulchenko, Yurii
Potter, Simon C.
Erdos, Michael R ...
Sanna, Serena
Hottenga, Jouke- ...
Wheeler, Eleanor
Kaakinen, Marika
Lyssenko, Valeri ...
Chen, Wei-Min
Ahmadi, Kourosh
Beckmann, Jacque ...
Bergman, Richard ...
Bochud, Murielle
Bonnycastle, Lor ...
Buchanan, Thomas ...
Cao, Antonio
Cervino, Alessan ...
Coin, Lachlan
Collins, Francis ...
Crisponi, Laura
De Geus, Eco J. ...
Dehghan, Abbas
Deloukas, Panos
Doney, Alex S. F ...
Elliott, Paul
Freimer, Nelson
Gateva, Vesela
Herder, Christia ...
Hofman, Albert
Hughes, Thomas E ...
Hunt, Sarah
Illig, Thomas
Inouye, Michael
Isomaa, Bo
Johnson, Toby
Kong, Augustine
Krestyaninova, M ...
Kuusisto, Johann ...
Laakso, Markku
Lim, Noha
Lindblad, Ulf
Lindgren, Cecili ...
McCann, Owen T.
Mohlke, Karen L.
Morris, Andrew D ...
Naitza, Silvia
Orru, Marco
Palmer, Colin N. ...
Pouta, Anneli
Randall, Joshua
Rathmann, Wolfga ...
Saramies, Jouko
Scheet, Paul
Scott, Laura J.
Scuteri, Angelo
Sharp, Stephen
Sijbrands, Eric
Smit, Jan H.
Song, Kijoung
Steinthorsdottir ...
Stringham, Heath ...
Tuomi, Tiinamaij ...
Tuomilehto, Jaak ...
Uitterlinden, An ...
Voight, Benjamin ...
Waterworth, Dawn
Wichmann, H-Eric ...
Willemsen, Gonne ...
Witteman, Jacque ...
Yuan, Xin
Zhao, Jing Hua
Zeggini, Elefthe ...
Schlessinger, Da ...
Sandhu, Manjinde ...
Boomsma, Dorret ...
Uda, Manuela
Spector, Tim D.
Penninx, Brenda ...
Altshuler, David
Vollenweider, Pe ...
Jarvelin, Marjo ...
Lakatta, Edward
Waeber, Gerard
Fox, Caroline S.
Peltonen, Leena
Groop, Leif
Mooser, Vincent
Cupples, L. Adri ...
Thorsteinsdottir ...
Boehnke, Michael
Barroso, Ines
Van Duijn, Corne ...
Dupuis, Josee
Watanabe, Richar ...
Stefansson, Kari
McCarthy, Mark I ...
Wareham, Nichola ...
Meigs, James B.
Abecasis, Goncal ...
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Endocrinology an ...
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Health Sciences
and Public Health Gl ...
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and General Practice
Articles in the publication
Nature Genetics
By the university
Lund University
University of Gothenburg

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