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Träfflista för sökning "WFRF:(Dara J) ;lar1:(kth)"

Search: WFRF:(Dara J) > Royal Institute of Technology

  • Result 1-3 of 3
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1.
  • Kehoe, Laura, et al. (author)
  • Make EU trade with Brazil sustainable
  • 2019
  • In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341-
  • Journal article (other academic/artistic)
  •  
2.
  • Haque, Rehnuma, et al. (author)
  • Wastewater surveillance of SARS-CoV-2 in Bangladesh : Opportunities and challenges
  • 2022
  • In: CURRENT OPINION IN ENVIRONMENTAL SCIENCE & HEALTH. - : Elsevier BV. - 2468-5844. ; 27, s. 100334-
  • Journal article (peer-reviewed)abstract
    • The ongoing pandemic of the coronavirus disease 2019 (COVID-19) is a public health crisis of global concern. The progression of the COVID-19 pandemic has been monitored in the first place by testing symptomatic individuals for SARS-CoV-2 virus in the respiratory samples. Concurrently, wastewater carries feces, urine, and sputum that potentially contains SARS-CoV-2 intact virus or partially damaged viral genetic materials excreted by infected individuals. This brings significant opportunities for understanding the infection dynamics by environmental surveillance. It has advantages for the country, especially in densely populated areas where individual clinical testing is difficult. However, there are several challenges including: 1) establishing a sampling plan and schedule that is representative of the various catchment populations 2) development and validation of standardized protocols for the laboratory analysis 3) understanding hydraulic flows and virus transport in complex wastewater drainage systems and 4) collaborative efforts from government agencies, NGOs, public health units and academia.
  •  
3.
  • Mohammad, Dara K., et al. (author)
  • B Cell Receptor Activation Predominantly Regulates AKT-mTORC1/2 Substrates Functionally Related to RNA Processing
  • 2016
  • In: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 11:8
  • Journal article (peer-reviewed)abstract
    • Protein kinase B (AKT) phosphorylates numerous substrates on the consensus motif RXRXXpS/T, a docking site for 14-3-3 interactions. To identify novel AKT-induced phosphorylation events following B cell receptor (BCR) activation, we performed proteomics, biochemical and bioinformatics analyses. Phosphorylated consensus motif-specific antibody enrichment, followed by tandem mass spectrometry, identified 446 proteins, containing 186 novel phosphorylation events. Moreover, we found 85 proteins with up regulated phosphorylation, while in 277 it was down regulated following stimulation. Up regulation was mainly in proteins involved in ribosomal and translational regulation, DNA binding and transcription regulation. Conversely, down regulation was preferentially in RNA binding, mRNA splicing and mRNP export proteins. Immunoblotting of two identified RNA regulatory proteins, RBM25 and MEF-2D, confirmed the proteomics data. Consistent with these findings, the AKT-inhibitor (MK-2206) dramatically reduced, while the mTORC-inhibitor PP242 totally blocked phosphorylation on the RXRXXpS/T motif. This demonstrates that this motif, previously suggested as an AKT target sequence, also is a substrate for mTORC1/2. Proteins with PDZ, PH and/or SH3 domains contained the consensus motif, whereas in those with an HMG-box, H15 domains and/or NF-X1-zinc-fingers, the motif was absent. Proteins carrying the consensus motif were found in all eukaryotic clades indicating that they regulate a phylogenetically conserved set of proteins.
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  • Result 1-3 of 3
Type of publication
journal article (3)
Type of content
peer-reviewed (2)
other academic/artistic (1)
Author/Editor
Bhattacharya, Prosun ... (1)
Rothhaupt, Karl-Otto (1)
Weigend, Maximilian (1)
Farrell, Katharine N ... (1)
Islar, Mine (1)
Krause, Torsten (1)
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Uddling, Johan, 1972 (1)
Alexanderson, Helena (1)
Schneider, Christoph (1)
Battiston, Roberto (1)
Lukic, Marko (1)
Pereira, Laura (1)
Riggi, Laura (1)
Cattaneo, Claudio (1)
Jung, Martin (1)
Andresen, Louise C. (1)
Kasimir, Åsa (1)
Wang-Erlandsson, Lan (1)
Rahman, Mahbubur (1)
Raqib, Rubhana (1)
Sutherland, William ... (1)
Boonstra, Wiebren J. (1)
Vajda, Vivi (1)
Pascual, Unai (1)
Tscharntke, Teja (1)
Brown, Calum (1)
Peterson, Gustaf (1)
Meyer, Carsten (1)
Seppelt, Ralf (1)
Johansson, Maria (1)
Mohammad, Dara K. (1)
Martin, Jean Louis (1)
Olsson, Urban (1)
Hortal, Joaquin (1)
Buckley, Yvonne (1)
Petrovan, Silviu (1)
Schindler, Stefan (1)
Carvalho, Joana (1)
Amin, Nuhu (1)
Haque, Rehnuma (1)
Rahman, Mohammed Zia ... (1)
Mahmud, Zahid Hayat (1)
Hasan, Rezaul (1)
Sarker, Protim (1)
Akter, Nargis (1)
Johnston, Dara (1)
Shirin, Tahmina (1)
Amo, Luisa (1)
Machordom, Annie (1)
De Smedt, Pallieter (1)
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University
Royal Institute of Technology  (3)Undo refine
Lund University (1)
Mid Sweden University (1)
Chalmers University of Technology (1)
Karolinska Institutet (1)
Swedish University of Agricultural Sciences (1)
Language
English (3)
Research subject (UKÄ/SCB)
Natural sciences (2)
Engineering and Technology (2)
Medical and Health Sciences (1)
Social Sciences (1)

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