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Organ-Restricted Va...
Organ-Restricted Vascular Delivery of Nanoparticles for Lung Cancer Therapy
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- Bölükbas, Deniz (författare)
- Lund University,Lunds universitet,Lungbioengineering och regeneration,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Lung Bioengineering and Regeneration,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Ludwig-Maximilian University of Munich
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- Datz, Stefan (författare)
- Ludwig-Maximilian University of Munich
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- Meyer-Schwickerath, Charlotte (författare)
- Ludwig-Maximilian University of Munich
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- Morrone, Carmela (författare)
- Ludwig-Maximilian University of Munich
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- Doryab, Ali (författare)
- Ludwig-Maximilian University of Munich,World Orthopaedic Concern,German Center for Lung Research (DZL),Helmholtz Zentrum München
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- Gössl, Dorothee (författare)
- Technical University of Munich
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- Vreka, Malamati (författare)
- Ludwig-Maximilian University of Munich,University of Patras,German Center for Lung Research (DZL)
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- Yang, Lin (författare)
- Ludwig-Maximilian University of Munich
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Argyo, Christian (författare)
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van Rijt, Sabine (författare)
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- Lindner, Michael (författare)
- Asklepios Fachkliniken München-Gauting,Asklepios Clinics
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- Eickelberg, Oliver (författare)
- University Hospital Munich,Helmholtz Zentrum München,German Center for Lung Research (DZL),University of Colorado,World Orthopaedic Concern
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- Stoeger, Tobias (författare)
- Helmholtz Zentrum München
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- Schmid, Otmar (författare)
- Helmholtz Zentrum München,German Center for Lung Research (DZL)
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- Lindstedt, Sandra (författare)
- Lund University,Lunds universitet,Thoraxkirurgi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,DCD transplantation av lungor,Forskargrupper vid Lunds universitet,NPWT teknologin,Klinisk och experimentell lungtransplantation,Lungbioengineering och regeneration,WCMM- Wallenberg center för molekylär medicinsk forskning,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Thoracic Surgery,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,DCD transplantation of lungs,Lund University Research Groups,NPWT technology,Clinical and experimental lung transplantation,Lung Bioengineering and Regeneration,WCMM-Wallenberg Centre for Molecular Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Stathopoulos, Georgios T (författare)
- University of Patras,Ludwig-Maximilian University of Munich,German Center for Lung Research (DZL)
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- Bein, Thomas (författare)
- Ludwig-Maximilian University of Munich
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- Wagner, Darcy E. (författare)
- Lund University,Lunds universitet,Lungbioengineering och regeneration,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Lung Bioengineering and Regeneration,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Meiners, Silke (författare)
- German Center for Lung Research (DZL),World Orthopaedic Concern,University Hospital Munich
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(creator_code:org_t)
- 2020-05-13
- 2020
- Engelska.
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Ingår i: Advanced Therapeutics. - : Wiley. - 2366-3987. ; 3:7
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://onlinelibrar...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Nanoparticle-based targeted drug delivery holds promise for treatment of cancers. However, most approaches fail to be translated into clinical success due to ineffective tumor targeting in vivo. Here, the delivery potential of mesoporous silica nanoparticles (MSN) functionalized with targeting ligands for epidermal growth factor receptor and C─C chemokine receptor type 2 is explored in lung tumors. The addition of active targeting ligands on MSNs enhances their uptake in vitro but fails to promote specific delivery to tumors in vivo, when administered systemically via the blood or locally to the lung into immunocompetent murine lung cancer models. Ineffective tumor targeting is due to efficient clearance of the MSNs by the phagocytic cells of the liver, spleen, and lung. These limitations, however, are successfully overcome using a novel organ-restricted vascular delivery (ORVD) approach. ORVD in isolated and perfused mouse lungs of Kras-mutant mice enables effective nanoparticle extravasation from the tumor vasculature into the core of solid lung tumors. In this study, ORVD promotes tumor cell-specific uptake of nanoparticles at cellular resolution independent of their functionalization with targeting ligands. Organ-restricted vascular delivery thus opens new avenues for optimized nanoparticles for lung cancer therapy and may have broad applications for other vascularized tumor types.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- biological barriers
- lung cancer
- nanoparticles
- organ-restricted vascular delivery
- solid tumors
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Bölükbas, Deniz
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Datz, Stefan
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Meyer-Schwickera ...
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Morrone, Carmela
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Doryab, Ali
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Gössl, Dorothee
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visa fler...
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Vreka, Malamati
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Yang, Lin
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Argyo, Christian
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van Rijt, Sabine
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Lindner, Michael
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Eickelberg, Oliv ...
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Stoeger, Tobias
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Schmid, Otmar
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Lindstedt, Sandr ...
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Stathopoulos, Ge ...
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Bein, Thomas
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Wagner, Darcy E.
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Meiners, Silke
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