| 1. |
- Ertoprak, Aysegul, et al.
(författare)
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Lifetime measurements of core-excited states in semi-magic 95Rh
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Lifetimes of negative-parity states have been determined in the semi-magic (N=50) nucleus 95Rh. The fusion-evaporation reaction 58Ni(40Ca, 3p) was used to populate high-spin states in 95Rh at the Grand Accelerateur National d'Ions Lourds (GANIL) accelerator facility. The results were obtained using the Doppler Shift Attenuation Method (DSAM) based on the Doppler broadened line shapes produced during the slowing down process of the residual nuclei in a thick 6~ mg/cm2 metallic target. B(M1) and B(E2) reduced transition strengths are compared with predictions from large-scale shell-model calculations.
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| 2. |
- Ertoprak, Aysegul, 1987-, et al.
(författare)
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M1 and E2 transition rates from core-excited states in semi-magic 94Ru
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Lifetimes of high-spin states have been measured in the semi-magic (N=50) nucleus 94Ru. Excited states in 94Ru were populated in the 58Ni(40Ca, 4p)94Ru∗ fusion-evaporation reaction at the Grand Accelerateur National d’Ions Lourds (GANIL) accelerator complex. DSAM lifetime analysis was performed on the Doppler broadened line shapes in energy spectra obtained from γ-rays emitted while the residual nuclei were slowing down in a thick 6 mg/cm2 metallic 58Ni target. In total eight excited-state lifetimes in the angular momentum range I = (13 − 20)ħ have been measured, five of which were determined for the first time. The deduced corresponding B(M1) and B(E2)reduced transition strengths are discussed within the framework of large-scale shell model calculations to study the contribution of different particle-hole configurations, in particular for analyzing contributions from core-excited configurations.
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| 3. |
- Khalili, Bita, et al.
(författare)
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Associations between common genetic variants and income provide insights about the socioeconomic health gradient
- 2024
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- We conducted a genome-wide association study (GWAS) on income among individuals of European descent and leveraged the results to investigate the socio-economic health gradient (N=668,288). We found 162 genomic loci associated with a common genetic factor underlying various income measures, all with small effect sizes. Our GWAS-derived polygenic index captures 1 - 4% of income variance, with only one-fourth attributed to direct genetic effects. A phenome-wide association study using this polygenic index showed reduced risks for a broad spectrum of diseases, including hypertension, obesity, type 2 diabetes, coronary atherosclerosis, depression, asthma, and back pain. The income factor showed a substantial genetic correlation (0.92, s.e. = .006) with educational attainment (EA). Accounting for EA's genetic overlap with income revealed that the remaining genetic signal for higher income related to better mental health but reduced physical health benefits and increased participation in risky behaviours such as drinking and smoking.
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| 4. |
- Sahin, Cagla, et al.
(författare)
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Structural basis for dityrosine-mediated inhibition of alpha-synuclein fibrillation
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- α-synuclein (aSyn) is a small intrinsically disordered protein which can self-assemble into highly organized β-sheet structures that are found to accumulate in plaques in the brain of Parkinson’s Disease patients. Oxidative stress has been shown to be important for aSyn and its self-assembly. Here we characterize the molecular and structural effects that mild oxidation has on aSyn monomer and its aggregation. Using a combination of biophysical methods, SAXS and native ion mobility mass spectrometry, we find that oxidation leads to formation of intramolecular dityrosine cross-linkages that reduce aSyn’s size by a factor of √2. MD simulations support our experimental results showing a stable and compact aSyn conformation that prevents self-assembly and amyloid formation by steric hindrance, suggesting an important role of mild oxidation in preventing amyloid formation.
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