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Sökning: WFRF:(Dehlendorff Christian)

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1.
  • Tibaek, Sigrid, et al. (författare)
  • Prevalence of Lower Urinary Tract Symptoms (LUTS) in stroke patients: A cross-sectional, clinical survey.
  • 2008
  • Ingår i: Neurourology and Urodynamics. - : John Wiley and Sons. - 0733-2467 .- 1520-6777. ; Jun 12, s. 763-771
  • Tidskriftsartikel (refereegranskat)abstract
    • AIMS: The aims of this study were primarily to investigate the prevalence, severity and impact on daily life of Lower Urinary Tract Symptoms (LUTS) in a clinical sample of stroke patients and secondly to identify factors associated with LUTS. MATERIALS AND METHODS: This was a cross-sectional, hospital based survey whereby stroke patients were invited by letter to complete The Danish Prostatic Symptom Score (DAN-PSS-1) questionnaire at least 1 month following their stroke. Subjects were asked to report the frequency and severity of their symptoms (symptom score) and the impact of each symptom on their daily life (bother score) over the previous fortnight. Of 519 stroke patients invited, 482 subjects were eligible. RESULTS: The response rate was 84%. The period prevalence of at least one symptom was 94%; the most frequent symptom was nocturia (76%) followed by urgency (70%) and daytime frequency (59%). The most severe symptom was urgency followed by nocturia and daytime frequency. Among respondents who had at least one symptom, the prevalence of bother was 78%. Likewise the most frequent bothersome symptom was nocturia (53%), followed by urgency (48%) and daytime frequency (40%). Paresis in legs, symptoms of urinary incontinence on admission, and use of analgesics were significantly associated with severity, whereas the prevalence and bother of LUTS could not be associated with other patient characteristics. CONCLUSION: LUTS are highly prevalent in stroke patients and have a major impact on daily life. Neurourol. Urodynam. (c) 2008 Wiley-Liss, Inc.
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2.
  • Dehlendorff, Christian, et al. (författare)
  • Analysis of computer experiments with multiple noise sources
  • 2010
  • Ingår i: Quality and Reliability Engineering International. - 0748-8017 .- 1099-1638. ; 26:2, s. 137-146
  • Tidskriftsartikel (refereegranskat)abstract
    • In this paper we present a modeling framework for analyzing computermodels with two types of variations. The paper is based on a case study of an orthopedic surgical unit, which has both controllable and uncontrollable factors. Our results show that this structure of variation can be modeled effectively with linear mixed effects models and generalized additive models
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3.
  • Dehlendorff, Christian, et al. (författare)
  • Conditional Value at Risk as a Measure for Waiting Time in Simulations of Hospital Units
  • 2010
  • Ingår i: Quality Technology & Quantitative Management. - 1684-3703 .- 1811-4857. ; 7:3, s. 321-336
  • Tidskriftsartikel (refereegranskat)abstract
    • The utility of conditional value at risk (CVaR) of a sample of waiting times as a measure for reducing long waiting times is evaluated with special focus on patient waiting times in a hospital. CVaR is the average of the longest waiting times, i.e., a measure at the tail of the waiting time distribution. The presented results are based on a discrete event simulation (DES) model of an orthopedic surgical unit at a university hospital in Denmark. Our analysis shows that CVaR offers a highly reliable performance measure. The measure targets the longest waiting times and these are generally accepted to be the most problematic from the points of view of both the patients and the management. Moreover, CVaR can be seen as a compromise between the well known measures: average waiting time and the maximum waiting time
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4.
  • Dehlendorff, Christian, et al. (författare)
  • Designing simulation experiments with controllable and uncontrollable factors
  • 2008
  • Ingår i: 2008 Winter Simuation Conference. - Piscataway, NJ : IEEE Communications Society. - 9781424427079 ; , s. 2909-2915
  • Konferensbidrag (refereegranskat)abstract
    • In this study we propose a new method for designing computer experiments inspired by the split plot designs used in physical experimentation. The basic layout is that each set of controllable factor settings corresponds to a whole plot for which a number of subplots, each corresponding to one combination of settings of the uncontrollable factors, is employed. The caveat is a desire that the subplots within each whole plot cover the design space uniformly. A further desire is that in the combined design, where all experimental runs are considered at once, the uniformity of the design space coverage should be guaranteed. Our proposed method allows for a large number of uncontrollable and controllable settings to be run in a limited number of runs while uniformly covering the design space for the uncontrollable factors
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5.
  • Dehlendorff, Christian, et al. (författare)
  • Designing simulation experiments with controllable and uncontrollable factors for applications in healthcare
  • 2011
  • Ingår i: Journal of the Royal Statistic Society, Series C. - 0035-9254 .- 1467-9876. ; 60:1, s. 31-49
  • Tidskriftsartikel (refereegranskat)abstract
    • We propose a new methodology for designing computer experiments that was inspired by the split-plot designs that are often used in physical experimentation. The methodology has been developed for a simulation model of a surgical unit in a Danish hospital. We classify the factors as controllable and uncontrollable on the basis of their characteristics in the physical system. The experiments are designed so that, for a given setting of the controllable factors, the various settings of the uncontrollable factors cover the design space uniformly. Moreover the methodology allows for overall uniform coverage in the combined design when all settings of the uncontrollable factors are considered at once
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6.
  • Tibaek, Sigrid, et al. (författare)
  • Are activity limitations associated with lower urinary tract symptoms in stroke patients? : A cross-sectional, clinical survey
  • 2009
  • Ingår i: Scandinavian Journal of Urology and Nephrology. - 0036-5599 .- 1651-2065. ; , s. 383-389
  • Tidskriftsartikel (refereegranskat)abstract
    • To assess self-reported activity limitations in a clinical sample of stroke patients and to identify their association with prevalence, severity and impact on daily life of lower urinary tract symptoms (LUTS). Material and methods . A cross-sectional, clinical survey was initiated whereby stroke patients were invited to complete four activity limitations measurements: Barthel Index, mobility velocity, mobility distance, mobility aids and one LUTS measurement: the Danish Prostatic Symptom Score (DAN-PSS-1) questionnaire. Of 519 stroke patients, 482 subjects were eligible. Results . The response rate was 84%. The activity limitations were reported by 17-34% depending on the measurement. Mobility velocity was highly significantly associated (p=0.01) with severity of LUTS. In the LUTS incontinence symptom group, Barthel Index and mobility velocity were significantly associated with prevalence [p=0.03, odds ratio (OR) 2.08 and p=0.05, OR 1.87, respectively]. Barthel Index and mobility distance were also associated with severity (p=0.03 and p=0.04, respectively) and Barthel Index was associated with the prevalence of bother (p=0.02, OR 2.12). Conclusion . This study indicate for the first time that activity limitations are closely related to LUTS in stroke patients and that rehabilitation should also be directed towards the treatment of LUTS.
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7.
  • Tibaek, Sigrid, et al. (författare)
  • Are activity limitations associated with lower urinary tract symptoms in stroke patients? A cross-sectional, clinical survey.
  • 2009
  • Ingår i: Scandinavian Journal of Urology and Nephrology. - : Taylor & Francis. - 0036-5599. ; 43:5, s. 383-389
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective . To assess self-reported activity limitations in a clinical sample of stroke patients and to identify their association with prevalence, severity and impact on daily life of lower urinary tract symptoms (LUTS). Material and methods . A cross-sectional, clinical survey was initiated whereby stroke patients were invited to complete four activity limitations measurements: Barthel Index, mobility velocity, mobility distance, mobility aids and one LUTS measurement: the Danish Prostatic Symptom Score (DAN-PSS-1) questionnaire. Of 519 stroke patients, 482 subjects were eligible. Results . The response rate was 84%. The activity limitations were reported by 17-34% depending on the measurement. Mobility velocity was highly significantly associated (p=0.01) with severity of LUTS. In the LUTS incontinence symptom group, Barthel Index and mobility velocity were significantly associated with prevalence [p=0.03, odds ratio (OR) 2.08 and p=0.05, OR 1.87, respectively]. Barthel Index and mobility distance were also associated with severity (p=0.03 and p=0.04, respectively) and Barthel Index was associated with the prevalence of bother (p=0.02, OR 2.12). Conclusion . This study indicate for the first time that activity limitations are closely related to LUTS in stroke patients and that rehabilitation should also be directed towards the treatment of LUTS.
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8.
  • Tibaek, Sigrid, et al. (författare)
  • Can pelvic floor muscle training improve quality of life in men with mild to moderate post-stroke and lower urinary tract symptoms?
  • 2017
  • Ingår i: European Journal of Physical and Rehabilitation Medicine. - : Edizioni Minerva Medica. - 1973-9087. ; 53:3, s. 416-425
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: Lower urinary tract symptoms (LUTS) have a significant impact on quality of life (QoL) in post-stroke patients. AIM: The aim of this study was to evaluate the effect of pelvic floor muscle training (PFMT) on QoL parameters in men with post-stroke LUTS. DESIGN: Randomized, controlled and single-blinded trial. SETTING: Outpatients, University Hospital. POPULATION: Thirty-one men, median age 68 (interquartile range 60-74) years, with post-stroke LUTS were included. Thirty participants completed the study. METHODS: The participants randomized to the treatment group were treated in a systematic, controlled and intensive PFMT program over 3 months (12 weekly sessions). The participants randomized to the control group did not receive specific LUTS treatment. The effect was measured on the 36-Item Short Form Health Survey (SF-36) and the Nocturia Quality-of-Life (N-QoL) Questionnaire. RESULTS: The results on SF-36 indicated significant improvement within pre- and post-test in the domains emotional role (median 77 to 100, P=0.03) and vitality (median 65 to 70, P=0.03) in the treatment group, but not the control group. There were no statistically significant differences between groups at pre-test, post-test or 6-month follow-up. The results on N-QoL indicated statistically significant differences between pre- and post-test in the bother/concern domain in both groups and in sleep/energy for the control group, but not the treatment group. There were no statistically significant differences between groups. CONCLUSIONS: PFMT may improve the emotional health and vitality domains of QoL in men with mild to moderate post-stroke and LUTS; however the improvements in the treatment group were not significantly better than for the control group. PFMT did not improve nocturia-related QoL. CLINICAL REHABILITATION IMPACT: This study is the first to evaluate the effect of PFMT on QoL parameters in men with mild to moderate post-stroke and LUTS. The results indicate some short-term effect on SF-36 but none on N-QoL. However, further studies with larger sample sizes and with less restrictive inclusion and exclusion criteria are requested.
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9.
  • Tibaek, Sigrid, et al. (författare)
  • Can pelvic floor muscle training improve qualityof life in men with mild to moderate post-strokeand lower urinary tract symptoms?
  • 2017
  • Ingår i: European Journal of Physical and Rehabilitation Medicine. - : Edizioni Minerva Medica. - 1973-9087 .- 1973-9095. ; 53:3, s. 416-425
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: Lower urinary tract symptoms (LUTS) have a significant impact on quality of life (QoL) in post‑stroke patients.AIM: The aim of this study was to evaluate the effect of pelvic floor muscle training (PFMT) on QoL parameters in men with post‑stroke LUTS.DESIGN: Randomized, controlled and single‑blinded trial.SETTING: Outpatients, University Hospital.POPULATION: Thirty‑one men, median age 68 (interquartile range 60-74) years, with post‑stroke LUTS were included. Thirty participants completed the study.METHODS: The participants randomized to the treatment group were treated in a systematic, controlled and intensive PFMT program over 3 months (12 weekly sessions). The participants randomized to the control group did not receive specific LUTS treatment. The effect was measured on the 36-Item Short Form Health Survey (SF-36) and the Nocturia Quality‑of‑Life (N‑QoL) Questionnaire.RESULTS: The results on SF-36 indicated significant improvement within pre- and post‑test in the domains emotional role (median 77 to 100, P=0.03) and vitality (median 65 to 70, P=0.03) in the treatment group, but not the control group. There were no statistically significant differences between groups at pre‑test, post‑test or 6-month follow‑up. The results on N‑QoL indicated statistically significant differences between pre- and post‑test in the bother/concern domain in both groups and in sleep/energy for the control group, but not the treatment group. There were no statistically significant differences between groups.CONCLUSIONS: PFMT may improve the emotional health and vitality domains of QoL in men with mild to moderate post‑stroke and LUTS; however the improvements in the treatment group were not significantly better than for the control group. PFMT did not improve nocturia‑related QoL.CLINICAL REHABILITATION IMPACT: This study is the first to evaluate the effect of PFMT on QoL parameters in men with mild to moderate post‑stroke and LUTS. The results indicate some short‑term effect on SF-36 but none on N‑QoL. However, further studies with larger sample sizes and with less restrictive inclusion and exclusion criteria are requested.
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10.
  • Tibaek, Sigrid, et al. (författare)
  • Is Pelvic Floor Muscle Training Effective for Men With Poststroke Lower Urinary Tract Symptoms? A Single-Blinded Randomized, Controlled Trial.
  • 2015
  • Ingår i: American Journal of Men's Health. - : SAGE Publications. - 1557-9883. ; , s. 1460-1471
  • Tidskriftsartikel (refereegranskat)abstract
    • The aim of the current study was to evaluate the effect of pelvic floor muscle training in men with poststroke lower urinary tract symptoms. Thirty-one poststroke men, median age 68 years, were included in this single-blinded randomized controlled trial. Thirty participants, 15 in each group, completed the study. The intervention consisted of 3 months (12 weekly sessions) of pelvic floor muscle training in groups and home exercises. The effect was evaluated by the DAN-PSS-1 (Danish Prostate Symptom Score) questionnaire, a voiding diary, and digital anal palpation of the pelvic floor muscle. The DAN-PSS-1, symptom score indicated a statistical significant improvement (p < .01) in the treatment group from pretest to posttest, but not in the control group. The DAN-PSS-1, total score improved statistically significantly in both groups from pretest to posttest (treatment group: p < .01; control group: p = .03). The median voiding frequency per 24 hours decreased from 11 at pretest to 7 (36%; p = .04) at posttest and to 8 (27%; p = .02) at follow-up in treatment group, although not statistical significantly more than the control group. The treatment group but not the control group improved statistically significantly in pelvic floor muscle function (p < .01) and strength (p < .01) from pretest to posttest and from pretest to follow-up (p = .03; p < .01). Compared with the control group the pretest to posttest was significantly better in the treatment group (p = .03). The results indicate that pelvic floor muscle training has an effect for lower urinary tract symptoms, although statistical significance was only seen for pelvic floor muscle.
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  • Resultat 1-10 av 12
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