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- Birney, Ewan, et al.
(författare)
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Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
- 2007
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 447:7146, s. 799-816
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Tidskriftsartikel (refereegranskat)abstract
- We report the generation and analysis of functional data from multiple, diverse experiments performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE Project. These data have been further integrated and augmented by a number of evolutionary and computational analyses. Together, our results advance the collective knowledge about human genome function in several major areas. First, our studies provide convincing evidence that the genome is pervasively transcribed, such that the majority of its bases can be found in primary transcripts, including non-protein-coding transcripts, and those that extensively overlap one another. Second, systematic examination of transcriptional regulation has yielded new understanding about transcription start sites, including their relationship to specific regulatory sequences and features of chromatin accessibility and histone modification. Third, a more sophisticated view of chromatin structure has emerged, including its inter-relationship with DNA replication and transcriptional regulation. Finally, integration of these new sources of information, in particular with respect to mammalian evolution based on inter- and intra-species sequence comparisons, has yielded new mechanistic and evolutionary insights concerning the functional landscape of the human genome. Together, these studies are defining a path for pursuit of a more comprehensive characterization of human genome function.
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- Bombois, X., et al.
(författare)
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Effect of model structure and signal-to-noise ratio on finite-time uncertainty bounding in prediction error identification
- 2009
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Ingår i: Proceedings of the 48th IEEE Conference on Decision and Control, 2009 held jointly with the 2009 28th Chinese Control Conference. CDC/CCC 2009. - : IEEE. - 9781424438716 ; , s. 494-499
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Konferensbidrag (refereegranskat)abstract
- In prediction error identification, confidence regions are most commonly derived from the asymptotic statistical properties of the parameter estimator. Therefore, these confidence regions are only asymptotically valid and, for finite samples, their actual coverage rate can be smaller than the desired coverage rate. In this paper, we analyze the influence of the SNR and of the type of model structure on the difference between the actual and desired coverage rates. In addition, we propose alternatives to the classical approach to constructing probabilistic confidence regions for Box-Jenkins systems.
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- Bombois, Xavier, et al.
(författare)
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Optimal experiment design for hypothesis testing applied to functional magnetic resonance imaging
- 2011
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Ingår i: Proceedings of the 18th IFAC World Congress. ; , s. 9953-9958
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Konferensbidrag (refereegranskat)abstract
- Hypothesis testing is a classical methodology of making decisions using experimental data. In hypothesis testing one seeks to discover evidence that either accepts or rejects a given null hypothesis H0. The alternative hypothesis H1 is the hypothesis that is accepted when H0 is rejected. In hypothesis testing, the probability of deciding H1 when in fact H0 is true is known as the false alarm rate, whereas the probability of deciding H1when in fact H1is true is known as the detection rate (or power) of the test. It is not possible to optimize both rates simultaneously. In this paper, we consider the problem of determining the data to be used for hypothesis testing that maximize the detection rate for a given false alarm rate. We consider in particular a hypothesis test which is relevant in functional magnetic resonance imaging (fMRI).
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